immunomodulating – Communicable Diseases Research

Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trial

Article

Published on 2022-09-202022-11-16
Journal: Trials [Category] SARS, 변종,

Prolonged COVID-19 symptom duration in people with systemic autoimmune rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey

Article

Published on 2022-09-012022-11-16
Journal: RMD Open [Category] 변종,

Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease

종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다

Observational Study

Published on 2022-07-052022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술,

[키워드] Against age antagonist antagonists anti-SARS-CoV-2 antibody anti-SARS-CoV-2 vaccination antibody Antibody concentrations Antibody titer Antibody titers Biologicals Blood blood sampling bowel Characteristics clinical Clinical characteristics Combination completion Concentration COVID-19 Crohn's disease defined demonstrated detectable disease Effect elapsed geometric geometric mean IBD IgG IgG antibodies IgG antibody IgG antibody titer IgG antibody titers immune response immunoassay immunomodulating Immunosuppressive medication immunosuppressive medications increased risk independent independent of Inflammatory Inflammatory bowel disease medication Microparticle monotherapy Most patients mRNA mRNA vaccines mRNA-based vaccine mRNA-based vaccines Multivariable models Patient patient age patients patients treated prospective observational cohort quantitative determination RBD receive receiving Receptor-binding domain regimen response S1 subunit sampling SARS-CoV-2 SARS-COV-2 infection Seroconversion serological response significantly lower Spike protein the receptor-binding domain the S1 subunit the spike protein titer TNF-α-antagonists treated Treatment Tumor ulcerative colitis vaccination Vaccine vector was used were measured were recorded
[DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study

Successful Immunomodulatory Treatment of COVID-19 in a Patient With Severe ACTH-Dependent Cushing’s Syndrome: A Case Report and Review of Literature

중증 ACTH 의존성 쿠싱증후군 환자에서 코로나19의 성공적인 면역조절 치료: 증례 보고 및 문헌 고찰

Review

Published on 2022-06-222022-09-12
Journal: Frontiers in Endocrinology [Category] MERS, 진단,

The Importance of Nutraceuticals in COVID-19: What’s the Role of Resveratrol?

COVID-19에서 기능식품의 중요성: 레스베라트롤의 역할은 무엇입니까?

Review

Published on 2022-04-072022-09-11
Journal: Molecules [Category] 치료제,

[키워드] acting adjuvant affected aggressiveness anti-inflammatory agent anti-inflammatory properties antiviral activity autophagy Cell characteristic concerning COVID-19 COVID-19 patients Cytokines decrease effective expression global public health immune Immune cell immune system Immunity immunomodulating Importance IMPROVE increase Infection infections Inflammation information inhibiting limit mechanisms Mortality Multiorgan dysfunction nutraceutical occur pathophysiology Patient Prevent pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines regulate resveratrol risk role solution the disease therapy thrombotic thrombotic event Thrombotic events urgency viral replication virus
[DOI] 10.3390/molecules27082376 PMC 바로가기 [Article Type] Review

Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice

2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다

Article

Published on 2022-03-222022-09-11
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration
[DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article

The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

OM-85 박테리아 용해물은 SARS-CoV-2 수용체 발현을 하향 조절하여 상피 세포의 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-03-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 비임상, 유전자 메커니즘,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 administration airway airway epithelial cells angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacteria Bacterial bacterial lysate binding bronchial epithelial cells caused Cell cell entry cell interactions cell lines coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 downregulated downregulating downregulation Effect enzyme epithelial epithelial cell epithelial cell line epithelial cells expression HEK293T cell host cells human airway human epithelial cell human epithelial cells immunomodulating in vitro infect Infection inhibit inhibited Interaction intestinal kidney lentiviral particles lentivirus lung mRNA Multiple OM-85 organ organs Prevent primary bronchial epithelial cells primary human bronchial epithelial cells protease PROTECT Protein Protein binding protein expression pseudotyped lentiviral particles reduce respiratory infections S protein S1 protein safety profile SARS-CoV-2 SARS-CoV-2 cell infection SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 S1 protein Serine serine 2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severity significantly TMPRSS2 Transcription transmembrane transmembrane protease serine 2 treated Treatment were measured
[DOI] 10.1016/j.jaci.2021.11.019 PMC 바로가기 [Article Type] Article

Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial

중등도 COVID-19 감염으로 입원한 환자를 위한 글리시리진 및 보스웰산 병용 치료: 무작위 임상 시험

Randomized Controlled Trial

Published on 2022-03-012022-09-10
Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 변종, 임상,

[키워드] Advancing Adverse adverse events age Anti-inflammatory Antiviral assigned Boswellic aids clinical clinical status Clinical status score Combination combination treatment COVID-19 death diagnosed double-blind drugs Efficacy eligibility eligible Enrollment evaluated event Evidence FIVE glycyrrhizin hospital hospitalized patient hospitalized patients Identifier immunomodulating Infection institutional protocol IQR matching placebo median median age Mild mild to moderate moderate Moderate COVID-19 moderate infection moderate symptoms Mortality mortality rate outcome Patient PCR test Placebo placebo group placebo-controlled Primary outcome Randomized randomized clinical trial randomized trial Randomly receive receiving recent Recovery time Registered required Safe SARS-CoV-2 secondary secondary outcome significant decrease significant difference significantly shorter single-center small sample size study drug Symptoms the placebo group therapeutic Time to recovery Treatment treatment of COVID-19 Trial university variant variants
[DOI] 10.1007/s10787-022-00939-7 PMC 바로가기 [Article Type] Randomized Controlled Trial

Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다

Article

Published on 2022-01-282022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제,

[키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread
[DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article

β-Glucans Could Be Adjuvants for SARS-CoV-2 Virus Vaccines (COVID-19)

Article

Published on 2021-11-302022-10-29
Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS,