Efficacy and safety of zapnometinib in hospitalised adult patients with COVID-19 (RESPIRE): a randomised, double-blind, placebo-controlled, multicentre, proof-of-concept, phase 2 trialArticle Published on 2023-10-042024-09-05 Journal: EClinicalMedicine [Category] update2024, [키워드] Anti-viral COVID-19 immunomodulator [DOI] 10.1016/j.eclinm.2023.102237 PMC 바로가기 [Article Type] Article
Dendrobium officinale aqueous extract influences the immune response following vaccination against SARS-CoV-2Article Published on 2023-04-132024-09-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] update2024, [키워드] COVID-19 Dendrobium officinale gut microbiota immunomodulator neutralizing antibody [DOI] 10.1016/j.biopha.2023.114702 PMC 바로가기 [Article Type] Article
Combination therapy with remdesivir and immunomodulators improves respiratory status in COVID-19: A retrospective studyArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% confidence interval Analysis Baricitinib baseline benefit body mass index combination therapy Concomitant contributed control group coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Day Diabetes Mellitus examined faster greater hazard ratio immunomodulator immunomodulators IMPROVE in both group independent investigated median outcome Oxygen administration Patient patients Prognostic factors Remdesivir respiratory recovery retrospective Retrospective study severity single-center study standard treatment supplemental oxygen survival synergistic therapy Tocilizumab treated two group [DOI] 10.1002/jmv.28037 PMC 바로가기
Curcumin partly prevents ISG15 activation via ubiquitin-activating enzyme E1-like protein and decreases ISGylationArticle Published on 2022-10-152022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] 치료제, [키워드] A549 cell activated Activation acute respiratory syndrome Affect and SARS-CoV-2 papain-like protease. contribute coronavirus coronavirus disease COVID-19 Curcumin decrease dose-dependent manner enzyme expression expression level function help immunomodulator Infection innate immune responses interferon interferon-stimulated gene Interferon-stimulated gene 15 kDa investigated ISG15 ISGylation kDa Modification monomer occur Papain-like protease pathogen Prevent Protein reduce SARS-CoV-2 severe COVID-19 Spread substrate suggested treated Treatment [DOI] 10.1016/j.bbrc.2022.08.003 PMC 바로가기
Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosisArticle Published on 2022-09-272022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] accompanied acute respiratory distress addition Comorbidity coronavirus disease COVID-19 COVID-19 pathology cytokine production decrease dysregulated immune response effective Efficacy Evidence functions glycyrrhiza Glycyrrhiza glabra Hamster model hamsters hypercoagulable IL-17A IL-4 immunocompromised individuals immunomodulator immunomodulatory properties Inflammatory cytokine ingredient Lung pathology lung viral load mice mice and human neutrophil functions. mitigate Mortality mRNA expression murine NET NETosis neutrophil polymorphonuclear neutrophil pro-inflammatory cytokine Protective provide Pulmonary pathology reduced reducing robust ROS SARS-CoV-2 SARS-COV-2 infection skewed suppress syndrome Th17 Th2 Th2/Th17 differentiation Treatment vaccination Vaccine variant [DOI] 10.3389/fimmu.2022.945583 PMC 바로가기
Impact of Immunotherapies on SARS-CoV-2-Infections and Other Respiratory Tract Infections during the COVID-19 Winter Season in IBD PatientsArticle Published on 2022-08-242022-11-15 Journal: Canadian journal of gastroenterology & hepatology [Category] SARS, 진단, [키워드] addition age analysed association Cohort collected Course COVID-19 COVID-19 infection death died Evidence First wave Frame General population Germany hospital hotspot IBD ICU Immunoglobulin immunomodulator Immunotherapy Impact increased risk infection risk Inflammatory bowel disease inhibitor majority medication Munich occurred Older age Other Oxygen treatment Patient patients patients died positive Prevent problem protective role question receive reduced respiratory respiratory tract respiratory tract infection Respiratory tract infections SARS-CoV-2 SARS-COV-2 infection season severe COVID-19 significantly subject Support susceptible symptomatic tested the healthy therapy TNF tract Treatment Winter [DOI] 10.1155/2022/3469789 PMC 바로가기
Encephalomyelitis associated with coronavirus disease 2019: a case report코로나바이러스 질병 2019와 관련된 뇌척수염: 사례 보고Case Reports Published on 2022-08-232022-09-12 Journal: Journal of Medical Case Reports [Category] 진단, [키워드] acute respiratory syndrome administration antibody article Asian Case report cerebrospinal fluid clinical Clinical improvement coronavirus coronavirus disease COVID-19 Deterioration diagnosed discharge DNA effective Encephalitis Encephalomyelitis female Fever high-dose methylprednisolone immunomodulator Infection Intravenous immunoglobulin Longitudinally extensive transverse myelitis. Loss of consciousness Manifestations Mild neurological neurological manifestation presenting steroid Symptoms the patient Treatment [DOI] 10.1186/s13256-022-03539-9 PMC 바로가기 [Article Type] Case Reports
NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis Research Published on 2022-06-062022-10-05 Journal: Nature nanotechnology [Category] 바이오마커, [키워드] addition Apoptosis approach Bacteremia Cell cells cellular death demonstrated help homoeostasis immune immunomodulator Infection Inflammation key factor life-threatening maintain modulating multidrug-resistant multiorgan injury NAD+ NADH organ dysfunction outcome Pathogenesis prevented Pseudomonas aeruginosa pyroptosis reduced responsible Sepsis suppressed the United State therapeutic efficacy therapy translational Transport treat Vascular function vascular homeostasis [DOI] 10.1038/s41565-022-01137-w [Article Type] Research
Assessing the developing pharmacotherapeutic landscape in hepatitis B treatment: a spotlight on drugs in phase II clinical trialsArticle Published on 2022-06-012023-06-12 Journal: Expert opinion on emerging drugs [Category] B형 간염, [키워드] CpAM Entry inhibitor functional cure HBsAg HBV immunomodulator NAPs polymerase inhibitor RNAi [DOI] 10.1080/14728214.2022.2074977
A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19Research article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 신약개발, 임상, [키워드] Action acute respiratory syndrome adaptive clinical testing consumer coronavirus disease-2019 Coronavirus-2 COVID COVID-19 COVID-19 disease current decrease doses double-blinded Effect Efficacy and safety Emergency Endpoint enrolled Estrogen European Commission evaluate Evidence finding FIVE funding hospitalized patients immunomodulator indications instrument Italian Italy lack mechanical ventilation Medicine Mild Ministry of Health mitigate moderate Moderate COVID-19 modulate multicenter Multicenter trial Nasopharyngeal swab Occurrence participant Patient pharmacological Phase 2 study Placebo placebo-controlled placebo-controlled trial Prevent Primary outcome progression proinflammatory cytokines proportion raloxifene Randomized receive Registered Replication reported Safety safety profile SARS-CoV-2 Selective estrogen receptor modulator (SERM) Serious Adverse Events Seven supplemental oxygen Supplemental oxygen therapy Support supported therapeutic option treat Treatment Trial undetectable viral shedding [DOI] 10.1016/j.eclinm.2022.101450 [Article Type] Research article