Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Impaired serological response to COVID-19 vaccination following anticancer therapy: A systematic review and meta-analysis항암 치료 후 코로나19 백신 접종에 따른 혈청학적 반응 저하: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-10-012022-09-12 Journal: Journal of medical virology [Category] Fulltext, MERS, 진단, [키워드] 95% confidence interval Affect anti-CD20 antibody anticancer association B-cell lymphoma Cancer cellular response Chemotherapy conducted coronavirus disease correlated COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstrated dose evaluate Fatality rate hormonal therapy humoral immune response Immunotherapy Impaired inhibitor Meta-analysis morbidity Odds ratio Patient patients Patients with cancer postvaccination Research response to vaccination risk Seroconversion seroconversion rate serological serological response significantly significantly lower subgroup analysis suggested systematic review targeted therapy therapy Treatment tyrosine vaccination Vaccination strategy Vaccine [DOI] 10.1002/jmv.27956 PMC 바로가기 [Article Type] Meta-Analysis
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccinationArticle Published on 2022-09-132022-11-15 Journal: Immunity [Category] COVID19(2023년), SARS, 진단, [키워드] B cells CD4 CD45RA CD8 Cell-mediated immunity Characteristics continuum COVID-19 elicited form functional highlighting Humoral immunity Immunocompromised patient Immunocompromised patients immunodeficiency Impaired in healthy individual individual lack leukemia mRNA vaccination mRNA vaccine Patient patients polyclonal response responses RNA-sequencing robust SARS-CoV-2 SARS-CoV-2-specific T cell single-cell profile solid-organ transplant spike-specific T cell syndrome T cell T cell response T cells vaccination X-linked agammaglobulinemia XLA [DOI] 10.1016/j.immuni.2022.07.005 PMC 바로가기
Heterologous vector versus homologous mRNA COVID-19 booster vaccination in non-seroconverted immunosuppressed patients: a randomized controlled trialArticle Published on 2022-09-122022-11-15 Journal: Nature Communications [Category] SARS, 진단, [키워드] 1:1 age Analysis antibody blinded BNT162b2 booster vaccination cellular immune responses ChAdOx1 nCoV-19 clinical trial COVID-19 COVID-19 vaccination determine dose Endpoint EudraCT Heterologous homologous Immunosuppressed immunosuppressed patients Impaired include mRNA mRNA vaccination mRNA vaccine mRNA-1273 multivariable logistic regression outcome Patient performed Randomized Randomized controlled trial receive reduced SARS-CoV-2 spike SARS-CoV-2-specific T-cell response secondary Serious Adverse Event Seroconversion seroconversion rate seroconvert significantly higher single center Support vaccination Vaccination strategy Vaccine vaccine group [DOI] 10.1038/s41467-022-33036-y PMC 바로가기
Reduced Serological Response to COVID-19 Vaccines in Patients with IBD is Further Diminished by TNF Inhibitor Therapy; Early Results of the VARIATION study [VAriability in Response in IBD Against SARS-COV-2 ImmunisatiON]Article Published on 2022-09-082022-11-15 Journal: Journal of Crohn's & colitis [Category] SARS, 진단, [키워드] Affect Against antagonists anti-SP IgG Anti-spike anti-TNF anti-tumour necrosis factor antagonists. Antibody Response booster vaccination bowel Cohort Complete COVID-19 COVID-19 vaccination determine Diagnosis diminished healthy control highlight IBD Immunoglobulin Impaired Inflammatory bowel disease inhibitor investigated medication mRNA vaccine Necrosis Patient Protein Quantitative receiving recruited response response to vaccination Result SARS-CoV-2 vaccination seroconvert seroconverted serological response significantly lower therapy TNF TNF antagonist Treatment vaccination vaccination against COVID-19 Vaccine vaccine response were assessed [DOI] 10.1093/ecco-jcc/jjac029 PMC 바로가기
Impaired activation of transposable elements in SARS-CoV-2 infectionArticle Published on 2022-09-052022-11-15 Journal: EMBO Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activate activated Activation Cell cellular changes in Chromatin structure correlation COVID-19 Defense drug target element elements Epigenetic epigenetics Evidence explain expression expression level functional Genes Host host immune system identify immune Impaired Infection interferon interferon response mechanism primary cells Proteins provide regulate robust SARS-CoV-2 SARS-COV-2 infection suggested the SARS-CoV-2 Transcription transposable elements. upregulation variable viral infections Viral load viruses [DOI] 10.15252/embr.202255101 PMC 바로가기
Impaired immunity and high attack rates caused by SARS-CoV-2 variants among vaccinated long-term care facility residentsArticle Published on 2022-09-012022-11-15 Journal: Immunity, Inflammation and Disease [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addressed Alpha variant antibody attack rate B.1.1.7 B.1.351 Beta Breakthrough infection Care caused cell-mediated immune response Cell-mediated immunity concentrations coronavirus COVID-19 COVID-19 outbreak COVID-19 vaccination elderly HCWs healthcare worker high risk IgG Immunity Immunoglobulin Impaired investigated Long-term care Long-term care facility marker NAb titer Neutralizing antibodies neutralizing antibody outbreak protocols SARS-CoV-2 variant second dose severe coronavirus disease spike glycoprotein susceptible vaccination vaccine doses vaccine response Vaccine-induced immunity variant variants [DOI] 10.1002/iid3.679 PMC 바로가기
Impaired humoral and cellular response to primary COVID-19 vaccination in patients less than 2 years after allogeneic bone marrow transplant동종 골수 이식 후 2년 미만의 환자에서 1차 COVID-19 예방 접종에 대한 체액 및 세포 반응 손상Article Published on 2022-08-012022-09-11 Journal: British Journal of Haematology [Category] MERS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse outcome adverse outcomes Allogeneic allogeneic bone marrow transplant analysed anti-S IgG Anti-spike BNT162b2 Bone marrow booster Cell Cell-mediated immunity cellular response ChAdOx1 Cohort coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) Coronavirus-2 COVID-19 COVID-19 vaccination Critical defined enzyme-linked immunospot Evidence evidence of haematopoietic stem cell transplant (HSCT) HCs healthy control high risk HSCT HSCT recipient HSCT recipients humoral IFNγ IgG Immunoglobulin Immunoglobulin G ImmunoSpot Impaired interferon less majority Patient Prophylactic prophylactic measure prophylactic measures rate of seroconversion recipient respiratory responders Seroconversion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) significantly higher significantly lower stem cell T-cell T-cell Response T-cell responses These data titre Transplant vaccination schedule Vaccination strategy Vaccine vaccine immunogenicity Vaccines variants [DOI] 10.1111/bjh.18312 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Amino acid antigenicity B.1.1.529 BNT162b2 booster vaccination Cell cell entry Cell fusion ChAdOx1 changes in cornerstone COVID-19 described determined by Effectiveness endosomal entry endosomal entry pathway Immune escape Impaired in vitro increasingly individual induce mapped mRNA mRNA-1273 Mutation neutralization omicron Omicron variant Omicron variants pathogenicity pathway phenotype public health Receptor-binding domain reduction in Region replicative restored S2 domain SARS-CoV-2 sera Spike protein Spread Syncytia the receptor-binding domain the spike protein These data TMPRSS2 transmissible variant underlie Vaccine variant VoC VOCs was determined [DOI] 10.1038/s41564-022-01143-7 PMC 바로가기 [Article Type] Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Research Published on 2022-07-282022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] acute infection acute respiratory distress Amino acid Analysis Applying ARDS carbon source CD4+ T cell CD4+ T cells COVID-19 Glycolysis highlight host adaptation immune response Impaired individual induce infected with SARS-CoV-2 infections influence interferon-γ ketogenic metabolism mice Mortality oxidative phosphorylation Patient promote provide Pulmonary infection pulmonary viral reducing severe COVID-19 severe respiratory infections skewed survival syndrome T cell T cell dysfunction T cell response [DOI] 10.1038/s41586-022-05128-8 [Article Type] Research