Selection of vaccine-candidate peptides from Mycobacterium avium subsp. paratuberculosis by in silico prediction, in vitro T-cell line proliferation, and in vivo immunogenicityImmunology Original Research Published on 2024-01-302024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] CD4+ T-cell lines IFN-γ in silico analysis MHC binding prediction Paratuberculosis peptide vaccine test interference [DOI] 10.3389/fimmu.2024.1297955 PMC 바로가기 [Article Type] Immunology Original Research
Improved performance of nucleic acid-based assays for genetically diverse norovirus surveillanceGenetics and Molecular Biology Published on 2023-10-042024-09-05 Journal: Applied and Environmental Microbiology [Category] update2024, [키워드] in silico analysis Norovirus nucleic acid-based assays PCR assays virus mutations virus surveillance [DOI] 10.1128/aem.00331-23 PMC 바로가기 [Article Type] Genetics and Molecular Biology
Monocytes subsets altered distribution and dysregulated plasma hsa-miR-21-5p and hsa-miR-155-5p in HCV-linked liver cirrhosis progression to hepatocellular carcinomaarticle Published on 2023-08-282024-09-05 Journal: Journal of Cancer Research and Clinical Oncology [Category] update2024, [키워드] HCC hsa-miR-155-5p hsa-miR-21-5p in silico analysis Liver cirrhosis monocyte subsets [DOI] 10.1007/s00432-023-05313-w PMC 바로가기 [Article Type] article
In Silico Prediction and Molecular Docking of SNPs in NRP1 Gene Associated with SARS-COV-2Original Article Published on 2023-06-092024-09-05 Journal: Biochemical Genetics [Category] update2024, [키워드] in silico analysis Neuropilin-1 (NRP1) SARS-CoV-2 Single nucleotide polymorphism (SNP) [DOI] 10.1007/s10528-023-10409-6 PMC 바로가기 [Article Type] Original Article
In Silico Prediction of Hub Genes Involved in Diabetic Kidney and COVID-19 Related Disease by Differential Gene Expression and Interactome AnalysisArticle Published on 2022-12-192023-07-11 Journal: Genes [Category] COVID19(2023년), [키워드] COVID-19 diabetic kidney disease hub genes in silico analysis metabolic pathways potential therapeutic. [DOI] 10.3390/genes13122412 PMC 바로가기
Utility of in silico-identified-peptides in spike-S1 domain and nucleocapsid of SARS-CoV-2 for antibody detection in COVID-19 patients and antibody productionArticle Published on 2022-09-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2D structure 3D structure analyzed antibody Antibody detection antibody production Antibody Response Antigen antigenic peptides changes in COVID-19 patient COVID-19 patients domain eight Evidence homology immunogenic in silico analysis limitation N protein New nucleocapsid peptide performed Proteins provide RBD Result S1 domain SARS-CoV-2 SARS-CoV-2 variant selected sequence serum serum sample Seven Standardization structural proteins the N protein the spike protein trimer virus viruses were used [DOI] 10.1038/s41598-022-18517-w PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기
The Rv3874-Rv3875 chimeric protein shows a promiscuous serodiagnostic potential for tuberculosisArticle Published on 2022-09-012022-11-15 Journal: Tuberculosis (Edinburgh, Scotland) [Category] 진단, [키워드] addition Antigen CEP Fusion chimeric cloned COVID-19 death Diagnostic method diagnostic potential early diagnosis EC Skin test ELISA epitope Escherichia coli BL21 expressed female HIV in silico analysis male subject molecular Mycobacterium tuberculosis novel Novel epitope prediction polyclonal antibody positive preliminary findings Protein purified reported secondary structure sensitivity serodiagnostic serum serum sample skin statistical Tuberculosis [DOI] 10.1016/j.tube.2022.102253 PMC 바로가기
Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approachSARS-COV-2에 대한 내생 세균의 2차 대사 산물의 생리 활성 가능성: In-silico 접근Article Published on 2022-08-042022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, 치료제, [키워드] 3CLpro accelerate accession number aligned ammonia analyses Analysis analyzed antioxidant approach associations Bacillus Bacteria Bacterial biochemically chymotrypsin Chymotrypsin-like protease collected Compound computational tool coronavirus Culture docked docking scores drug-likeness effective enzyme flask culture flavonoid GenBank identify in silico analysis in-silico inhibitor Interaction isolate Lopinavir metabolite metabolites Micrococcus morphologically nine NMR nucleotide nucleotide sequence outcome performed phytohormone plant profiles protease protein-protein network protein-protein networks protocol Pseudomonas species rDNA reported Research Sanger sequencing Secondary Metabolite sequence similarity Staphylococcus structures submission target protein target proteins tested these compounds was performed were assessed [DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article
COVID-19 and alcohol use disorder: putative differential gene expression patterns that might be associated with neurological complicationsArticle Published on 2022-08-012023-07-09 Journal: Hospital practice (1995) [Category] COVID19(2023년), [키워드] alcoholism COVID-19 in silico analysis neurological manifestations SARS-CoV-2 [DOI] 10.1080/21548331.2022.2088183