Coronaviruses SARS-CoV, MERS-CoV, and SARS-CoV-2 helicase inhibitors: a systematic review of in vitro studiesarticle Published on 2023-05-262024-09-05 Journal: Journal of Virus Eradication [Category] update2024, [키워드] coronavirus Helicase In vitro assay inhibitors nsp13 systematic review [DOI] 10.1016/j.jve.2023.100327 PMC 바로가기 [Article Type] article
In vitro susceptibility profile of Plasmodium falciparum clinical isolates from Ghana to antimalarial drugs and polymorphisms in resistance markersarticle Published on 2022-10-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] drug resistance Genetic polymorphism In vitro assay malaria parasite ring survival assay West Africa [Article Type] article
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing VirusArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Vaccine viral fitness viral infection virus wild-type [DOI] 10.1128/spectrum.02379-22 PMC 바로가기
Fluorine Atoms on C6H5-Corrole Affect the Interaction with Mpro and PLpro Proteases of SARS-CoV-2: Molecular Docking and 2D-QSAR ApproachesArticle Published on 2022-09-192022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] 2D-QSAR 3CL pro acute respiratory syndrome binding binding affinity Compound compounds coronavirus correlation corroles cysteine protease decrease derivative docking score evaluated fluorine in silico in vitro In vitro assay increase in indicated inhibitor insertions Interaction M pro molecular docking MPro NMR nuclear Papain-like protease parameter physical-chemical PLPro protease Quantitative Region SARS-CoV-2 SARS-CoV-2 replication separated target the binding affinity two-dimensional was obtained [DOI] 10.3390/ijms231810936 PMC 바로가기
Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLproArticle Published on 2022-09-082022-11-15 Journal: Nature Communications [Category] SARS, 진단, 치료제, [키워드] 3CLpro accounted addition binding cleavage cleave computational method COVID-19 Efficiency Essential explain functional help Host Host immune response humans Hydrogen bond hydrophobic immune in viral In vitro assay information machine modulator NEMO NF-κB pathology polyprotein predict protease Proteins residue reveal SARS-CoV-2 Signaling specificity substrate the SARS-CoV-2 Variation [DOI] 10.1038/s41467-022-32922-9 PMC 바로가기
Repurposing drugs as COVID-19 therapies: A toxicity evaluationCOVID-19 치료제로 약물 용도 변경: 독성 평가Review Published on 2022-07-012022-09-11 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyzed anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity approved autophagy blockers chemical structures clinical trials contributed correlated COVID-19 CPE Cytopathic effect cytotoxicity database drug drug candidate drug candidates Drug interactions Drug repurposing Efficiency enrolled ether hERG High-throughput screening highlight house identify In vitro assay induce nonspecific pandemic Phospholipidosis profile repurposing SARS-CoV-2 Severe acute respiratory syndrome significantly Structure Toxicity [DOI] 10.1016/j.drudis.2022.04.001 PMC 바로가기 [Article Type] Review
Nebulized enriched heparin to treat no critical patients with Sars-Cov-2 Triple-blind clinical trialSars-Cov-2 삼중 맹검 임상 시험에서 중증 환자를 치료하지 않는 분무 농축 헤파린6700 Published on 2021-12-232022-09-10 Journal: Medicine [Category] 변종, 신약개발, 임상, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus 2 advance antiviral activity Antiviral agents ARMS both groups clinical protocol Clinical tests clinical trial collapse conducted coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical Diagnosis disease drug Efficacy group health systems heparin In vitro assay inhalation Intervention mechanism nebulized new virus outcome pandemic status participant Patient Placebo Pneumonia protocols Radiological Diagnosis receive Replication respiratory Respiratory disease SARS-CoV-2 selected Serious Adverse Events Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spread therapeutic approaches treat Treatment triple-blind urgency Vaccine variant Viral Viral load viral respiratory [DOI] 10.1097/MD.0000000000028288 PMC 바로가기 [Article Type] 6700
Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspectiveSpecial Report Published on 2021-10-142022-10-28 Journal: Bioanalysis [Category] COVID-19, MERS, SARS, [키워드] analytical tools assist attribute computational modeling COVID-19 COVID-19 pandemic COVID-19 vaccine dependent on develop highlight In vitro assay in vivo initial Mutation pandemic Perspective preclinical models predict provide Rapid SARS-CoV-2 Vaccine Vaccine design vaccine production vaccine response Viral protein virus viruses [DOI] 10.4155/bio-2021-0096 PMC 바로가기 [Article Type] Special Report
Methods to Measure Antibody Neutralization of Live Human Coronavirus OC43Article Published on 2021-10-142022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] antibody Antibody neutralization betacoronaviruses bind Cell children cross-neutralization Cytopathic effect described develop ELISA human coronavirus Human monoclonal antibody Human plasma Humoral response In vitro assay infected cells Infection Live virus measure monoclonal antibody Mortality neutralization assays neutralize Neutralizing activity Neutralizing antibodies OC43 recipients respiratory viral infection respiratory viral infections the spike protein viral neutralization [DOI] 10.3390/v13102075 PMC 바로가기 [Article Type] Article
High-throughput screening assays for SARS-CoV-2 drug development: Current status and future directionsSARS-COV-2 약물 개발을위한 고 처리량 스크리닝 분석 : 현재 상태 및 향후 방향Review Published on 2021-10-012022-08-31 Journal: Drug discovery today [Category] SARS, 신약개발, 치료제, [키워드] Accuracy acting acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 applied approach approved assays benefit coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current Cytopathic effect reduction assay data-driven detrimental drug Drug discovery Efficiency evaluate High-throughput screening identify In vitro assay leads life cycle mechanism pandemic Quantitative reduction respiratory SARS-CoV-2 SARS-CoV-2 drug SARS-CoV-2 life cycle target the SARS-CoV-2 true positives [DOI] 10.1016/j.drudis.2021.05.012 PMC 바로가기 [Article Type] Review