In silico drug repurposing against SARS-CoV-2 using an integrative transcriptomic profiling approach: Hydrocortisone and Benzhydrocodone as potential drug candidates against COVID-19통합 전사체 프로파일링 접근법을 사용하여 SARS-CoV-2에 대한 인실리코 약물 용도 변경: COVID-19에 대한 잠재적 약물 후보로서 히드로코르티손 및 벤즈히드로코돈Article Published on 2022-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ADAR alveolar cell Analysis Anti-viral antiviral immune response Benzhydrocodone binding affinity CASP1 cellular response Cellular responses Clinical studies clinical study complementary COVID-19 COVID-19 pathogenesis determine drug drug candidate Drug repurposing dysregulated enrichment enrichment analysis evaluated FDA-approved drug FOS hallmark HBEGF Host Hydrocortisone ICAM1 identify IFI35 immune system in silico in silico approaches in viral in vitro in vivo experiment infected with SARS-CoV-2 Infectious disease involved IRF2 JUN management MMP9 molecular molecular docking Pathogenesis pathway Pathways promise Protein protein-protein interaction Proteins Repurposed drug Repurposed drugs SARS-CoV-2 SARS-COV-2 infection Signal transduction STAT3 subject suggested transcriptomic transcriptomic profile transcriptomics up-regulated USP18 viral infectious disease [DOI] 10.1016/j.meegid.2022.105318 PMC 바로가기 [Article Type] Article
A simple reverse genetics method to generate recombinant coronaviruses재조합 코로나바이러스를 생성하는 간단한 역유전학 방법Article Published on 2022-05-042022-09-11 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance Antiviral assays antivirals biological property Biology cDNA Characteristics Complete coronavirus coronavirus genome coronavirus genomes Diagnosis effective Engineering facilitate fluorescent generate genetics genomic genomic variant genomic variants in vivo in vivo experiment in vivo experiments molecular Mutation Pathogens reagents reconstruction reporter reporter strain reverse genetics SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants serological serology severe acute respiratory syndrome Coronavirus simplicity Specific specific mutations Strains the SARS-CoV-2 the SARS-CoV-2 genome therapeutic variants viral pathogen virus wild-type [DOI] 10.15252/embr.202153820 PMC 바로가기 [Article Type] Article
Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative reviewReview Published on 2022-04-022022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] β‐d‐N4‐hydroxycytidine acute respiratory syndrome administration antiviral agent cause clinical clinical trials coronavirus coronavirus disease COVID‐19 COVID‐19 DNA Efficacy EIDD‐2801 error catastrophe expected host cell in vivo experiment inhibit molnupiravir Mutagenesis mutagenic mutated pandemic Patient Placebo RdRP recent finding Replication reported RNA‐dependent RNA polymerase SARS‐CoV‐2 therapeutic efficacy therapeutic strategy therapy Trial turn variant Viral RNA virus [DOI] 10.1002/jmv.27730 PMC 바로가기 [Article Type] Review
Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2Original Article Published on 2022-02-142022-10-30 Journal: Natural Products and Bioprospecting [Category] COVID-19, [키워드] 2019 novel coronavirus 3CLpro accumulated ACE ACE2 activity anti-inflammatory activity antiviral agent assumed caused Citrus Citrus flavonoids clinically coronavirus cough COVID-19 cytokine Cytokine storm death digestive effective ENhance enzyme Epidemic expression Health hesperetin HMGB1 host immunity identification IL-1β IL-6 immunoregulation in vitro in vivo experiment indicated inhibit inhibiting inhibitor LPS macrophage cell line molecular docking naringenin naringin Novel coronavirus outbreak Pneumonia predict Proinflammatory cytokine receptor SARS-CoV SARS-CoV-2 SARS-COV-2 infection subsequent supplementary material sweet the binding affinity Treatment Wuhan [DOI] 10.1007/s13659-022-00325-4 PMC 바로가기 [Article Type] Original Article
The “Invisible Enemy” SARS-CoV-2: Viral Spread and Drug Treatment“보이지 않는 적”SARS-COV-2 : 바이러스 스프레드 및 약물 치료Review Published on 2022-02-102022-08-31 Journal: Medicina [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition administration Alpha Beta clinical trial Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Delta documentation domain drug drug treatment drugs Efficacy experiment Gamma in silico in vitro in vivo experiment indicate Infection monoclonal antibodies monoclonal antibody monoclonal antibody therapy Mutation neutralization occur omicron Omicron variant pandemic Research respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shown Spike protein spreads strain subject Symptom the spike protein therapy Transmission treat Treatment variant Viral viral infection viral spread viral strain virus while [DOI] 10.3390/medicina58020261 PMC 바로가기 [Article Type] Review
Structure-based docking, pharmacokinetic evaluation, and molecular dynamics-guided evaluation of traditional formulation against SARS-CoV-2 spike protein receptor bind domain and ACE2 receptor complexOriginal Paper Published on 2021-10-182022-10-31 Journal: Chemicke Zvesti [Category] COVID-19, [키워드] ACE2 ACE2 receptor Analysis angiotensin-converting enzyme 2 antiviral property binding caffeic acid Cell classical clinical trial complex Computational docking study docking docking score domain Favipiravir FIVE Glide in silico in vivo experiment Interaction Kabasura kudineer Ligand MD simulation molecular molecular dynamics nontoxic outbreak pandemic PDB pharmacokinetic preventive measure Protein RBD receptor residue ribavirin SARS-CoV-2 SARS-CoV-2 spike protein selected Selection Shwas kuthar rasa Siddha suggested supplementary material Talisadi churna the SARS-CoV-2 therapeutic viral entry was performed was used [DOI] 10.1007/s11696-021-01917-z PMC 바로가기 [Article Type] Original Paper
Immunobiotic Lactobacilli Improve Resistance of Respiratory Epithelial Cells to SARS-CoV-2 InfectionArticle Published on 2021-09-152022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation acute respiratory syndrome Administered animal model Antiviral Calu-3 cell calu-3 cells carried CCL5 coronavirus COVID-19 CXCL10 production CXCL8 DDX58 Effect expression identify IFN-β IFNAR2 IL-6 immune response immunobiotics immunomodulatory immunomodulatory effect in vivo experiment Infection Influenza virus innate immune response knowledge Lactiplantibacillus plantarum lung mice modify modulated New coronavirus OAS1 outcome Probiotics reduce regulated Replication reported resistance respiratory respiratory epithelial cell respiratory epithelial cells Respiratory pathogens respiratory syncytial virus SARS-CoV-2 SARS-COV-2 infection stimulated strain susceptibility TLR3 Toll-like receptor 3 Treatment viral pathogens [DOI] 10.3390/pathogens10091197 PMC 바로가기 [Article Type] Article
Structural Insight into the Binding of Cyanovirin-N with the Spike Glycoprotein, M pro and PL pro of SARS-CoV-2: Protein–Protein Interactions, Dynamics Simulations and Free Energy CalculationsSARS-CoV-2의 스파이크 당단백질, M pro 및 PL pro와 시아노비린-N의 결합에 대한 구조적 통찰력: 단백질-단백질 상호작용, 역학 시뮬레이션 및 자유 에너지 계산Article Published on 2021-08-242022-09-10 Journal: Molecules [Category] MERS, 치료제, [키워드] Antiviral approach attachment binding binding affinities binding energy calculated calculation claimed contributed COVID-19 cyanobacteria cyanovirin-N Dynamics energy Evidence form Free global public health highest human ACE2 receptor in vitro in vivo experiment insight Interaction investigated involved M pro MPro molecular molecular docking molecular dynamics simulations Molecular mechanics offer pandemic phycocyanin PLpro polar protease Protein Proteins Replication replication of SARS-CoV-2 residue SARS-CoV-2 scytovirin Simulation Spike protein surface area the binding affinity the Spike the spike protein threat Viral Viral proteins [DOI] 10.3390/molecules26175114 PMC 바로가기 [Article Type] Article
Theobroma cacao L. compounds: Theoretical study and molecular modeling as inhibitors of main SARS-CoV-2 proteaseTheobroma cacao L. 화합물: 주요 SARS-CoV-2 프로테아제 억제제로서의 이론적 연구 및 분자 모델링Article Published on 2021-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료제, [키워드] acute respiratory syndrome alanyl antioxidant binding binding efficiency Bioflavonoids carbonyl cause chemical property Cocoa bean complex Compound coronavirus COVID-19 DFT enzyme evaluated free energy Free energy calculation Free energy calculations high affinity in silico in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 Ligand molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations naringin performed presenting protease Quantum mechanics rutin SARS-CoV-2 SARS-CoV-2 protease Severe acute respiratory syndrome starting point Structural analysis Theobroma cacao Theobroma cacao. [DOI] 10.1016/j.biopha.2021.111764 PMC 바로가기 [Article Type] Article
Combination Treatment With Remdesivir and Ivermectin Exerts Highly Synergistic and Potent Antiviral Activity Against Murine Coronavirus Infection렘데시비르와 이버멕틴의 병용 치료는 쥐 코로나바이러스 감염에 대해 높은 시너지 효과와 강력한 항바이러스 활성을 나타냅니다.Cellular and Infection Microbiology Published on 2021-07-302022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Against antiviral drug antiviral therapy Betacoronavirus Betacoronavirus genus both viruses Cell Chloroquine clinical clinical trial clinical trials Combination combination therapy combination treatment coronavirus COVID-19 COVID-19 pandemic cytokine level develop doxycycline drug drug therapy effective Efficacy evaluated exhibited Hepatitis highest IC50 IL-6 in vitro model in vivo experiment indicated infect Infection inhibitory investigated Ivermectin ivermectin treatment leukemia Live virus lowest Macrophage macrophages mechanism MHV mice monotherapy murine hepatitis virus potent RAW264.7 macrophage cells reduction Remdesivir Replication Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections selectivity index sequence identity significant reductions synergism synergistic tested the Betacoronavirus the disease therapy TNF-α Treatment Trial urgency viability Viral Viral RNA virus viruses [DOI] 10.3389/fcimb.2021.700502 PMC 바로가기 [Article Type] Cellular and Infection Microbiology