An electrochemical aptasensor with N protein binding aptamer-complementary oligonucleotide as probe for ultra-sensitive detection of COVID-19N 단백질 결합 앱타머-상보성 올리고뉴클레오티드를 COVID-19의 초고감도 검출을 위한 프로브로 사용하는 전기화학적 앱타센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, 치료제, [키워드] affected applied aptamer binding blood sample Blood samples changes in complementary Complementary DNA Concentration conformational COVID-19 COVID-19 epidemic COVID-19 in patients DNA double-stranded Early detection effective Electrochemical aptasensor gold hybridization Incubation linear relationship log logarithm N protein N protein detection probe R 2 Rapid Rapid COVID-19 diagnosis Regenerable aptamer sensor. reported sensor solution target the N protein throat swab throat swabs vaccination volunteers was measured [DOI] 10.1016/j.bios.2022.114436 PMC 바로가기 [Article Type] Article
Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains: A Systematic Review and Meta-analysisArticle Published on 2022-08-012022-11-16 Journal: JAMA Network Open [Category] SARS, 변종, [키워드] 95% CI Alpha variant average Beta caused conducted COVID-19 COVID-19 pandemic defined Delta delta variant described eligible facilitate identifying Incubation Incubation period infected children Infection information Isolation item key factor mean incubation period Meta-analysis mutated older patient omicron original outcome parameters Patient patients Period producing random-effect ranged reported Reporting review SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant searched Symptoms Transmission variant virulence [DOI] 10.1001/jamanetworkopen.2022.28008 PMC 바로가기
Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro비만 매개체는 SARS-CoV-2 감염 또는 시험관 내 1차 인간 폐 미세혈관 내피 세포 활성화에 영향을 미치지 않습니다Article Published on 2022-06-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated Activation addition Adhesion Molecule adipokines adipose Adipose tissue Alter Cell cells clinical clinical observations COVID-19 Critically ill driving dysfunction E-selectin endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction evidenced exacerbate excess exposure to expression fat Human human lung ICAM-1 IL-6 Incubation individuals induce Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory response Inflammatory responses influence initiated lack Leptin lung Lungs mechanism mediator mounted obese obese COVID-19 patients obesity observation other organs outcome phenotype plasma pro-inflammatory produced virus required response SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection selectin severe disease shown susceptibility susceptibility to infection susceptible systemic level tested tissue VCAM-1 Viral protein Viral proteins virus visceral with COVID-19 [DOI] 10.3389/fimmu.2022.879033 PMC 바로가기 [Article Type] Article
Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective cohort study (COVI-GAPP)COVID-19와 관련된 생리적 매개변수의 변화를 무증상으로 감지하기 위한 센서 팔찌의 사용 조사: 전향적 코호트 연구(COVI-GAPP)의 중간 분석Randomized Controlled Trial Published on 2022-06-212022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] age Algorithm Analysis baseline changes in cohort study COVID-19 diagnosed FIVE health & health informatics heart rate HRV Incubation infection control Interim interim analysis investigated investigation memory molecular National parameter participant Participants physiological Physiology positive presymptomatic prospective cohort study Public public health random randomised recall Recurrent Neural Network registration number respiratory rate Safety SARS-COV-2 infection selected sensitivity serological assays setting Short-Term Memory significant changes in symptom onset symptomatic temperature training set Trial Variability Virology were recorded [DOI] 10.1136/bmjopen-2021-058274 PMC 바로가기 [Article Type] Randomized Controlled Trial
Secondary Attack Rate, Transmission and Incubation Periods, and Serial Interval of SARS-CoV-2 Omicron Variant, SpainSARS-CoV-2 오미크론 변종, 스페인의 2차 공격률, 전파 및 잠복기, 연속 간격Article Published on 2022-06-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 attack attack rate Cantabria coronavirus coronavirus disease COVID-19 Delta Incubation Incubation period interval omicron Omicron variant Rate reduced respiratory infections SARS-CoV-2 secondary secondary attack rate severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spain Surveillance symptom onset Transmission vaccination Vaccination Status variant viruses zoonoses [DOI] 10.3201/eid2806.220158 PMC 바로가기 [Article Type] Article
Shorter Incubation Period among COVID-19 Cases with the BA.1 Omicron VariantBA.1 오미크론 변이체로 COVID-19 사례 중 잠복기 단축Article Published on 2022-05-232022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI absence Alpha variant collected Contact Contact tracing Control COVID-19 delta variant diagnosed eligible explain health center Incubation Incubation period Infectious disease Infectious diseases Japanese Japanese Public Health Center law Log-normal distribution omicron Omicron variant Patient PCR-confirmed COVID-19 Period Public public health Public health center SARS-CoV-2 significantly shorter symptomatic patient the SARS-CoV-2 thought Transmission variant [DOI] 10.3390/ijerph19106330 PMC 바로가기 [Article Type] Article
A fast extraction-free isothermal LAMP assay for detection of SARS-CoV-2 with potential use in resource-limited settings자원이 제한된 환경에서 잠재적으로 사용할 수 있는 SARS-CoV-2 검출을 위한 빠른 추출이 필요 없는 등온 LAMP 분석Article Published on 2022-05-022022-09-11 Journal: Virology Journal [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] alternative method analysed Analysis caused clinical sample clinical samples conditions country current demonstrated determine disease equipment extracted RNA extraction Extraction-free LAMP IMPROVE Incubation isothermal isothermal amplification LAMP limit of detection London management Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples non-specific not affect nucleic acid PCR phosphate Phosphate Buffered Saline primer pair primer pairs qRT-PCR Quantitative reaction reagents resource resource-limited settings RLS RNA RT-PCR RT-PCR assays SARS-CoV-2 Sensitivity and specificity significantly Spread Street suggested tested Viral viral transport media were used [DOI] 10.1186/s12985-022-01800-7 PMC 바로가기 [Article Type] Article
Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary ciliavimentin, ACE2 및 SARS-CoV-2 스파이크 단백질의 세포 표면 검출은 일차 섬모에서 선택적 공동 국소화를 나타냅니다Article Published on 2022-04-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acetylated tubulin Arl13b binding Cell cell surface cell types cells cellular receptor cellular receptors ciliated cytoplasm docking Extracellular facilitate filament protein immunoreactivity Incubation Interaction Intermediate filament marker moderate occur Particle plasma membrane platform positive Protein receptor reported reveal S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective spike Spike protein Spike proteins structures tubulin vimentin viral invasion virus [DOI] 10.1038/s41598-022-11248-y PMC 바로가기 [Article Type] Article
Transmission dynamics of COVID-19 in household and community settings in the United Kingdom, January to March 20202020년 1월부터 3월까지 영국의 가정 및 지역 사회 환경에서 COVID-19의 전파 역학Article Published on 2022-04-012022-09-11 Journal: Eurosurveillance [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] 95% CI age Asia attack attack rate Community confirmed case confirmed cases Contact COVID-19 COVID-19 transmission early stage early stages form Health Organization highest highlight household household contacts household transmission Incubation Incubation period individual interval mean incubation period outcomes pandemic preventative measure preventative measures protocol reported reproduction Reproduction number reproduction numbers risk SAR secondary secondary attack rate secondary cases Serial interval Study design Surveillance symptoms of COVID-19 Transmission dynamics United Kingdom World Health Organization [DOI] 10.2807/1560-7917.ES.2022.27.15.2001551 PMC 바로가기 [Article Type] Article
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signalingSARS-CoV-2의 스파이크 단백질은 인테그린 α5β1 및 NF-κB 신호 전달을 통해 내피 염증을 유도합니다Article Published on 2022-03-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 activate Activation addition adhesion Adhesion Molecule administration bind Blood Capillaries CD45 Coagulation coagulation factor Coagulation factors COVID-19 Critical Cytokines dependent on domain dysfunction dysregulated edema Effects endothelial Endothelial cell endothelial cells Endothelial dysfunction expression FVIII hallmark hallmarks homeostasis ICAM1 IL-1β IL-6 in vivo increased expression Incubation induce Inflammation inflammatory phenotype inhibitor inhibitors integrin intravenous Intravenous administration intravitreal injection kidney leukocyte leukocytes liver lung maintain mechanism motif NF-κB NF-κB signaling nuclear translocation occur Peripheral blood peripheral blood leukocyte peripheral blood leukocytes permeability prevented Proinflammatory cytokine proinflammatory cytokines Receptor-binding domain responsible SARS-CoV-2 severe disease Signaling Spike protein spike protein of SARS-CoV-2 subsequent target gene the receptor-binding domain the spike protein tissue tissues TNFα umbilical umbilical vein vascular effect vascular endothelial cells vascular inflammation vascular leakage VCAM1 [DOI] 10.1016/j.jbc.2022.101695 PMC 바로가기 [Article Type] Article