infect cell – Communicable Diseases Research

SARS-CoV-2 requires acidic pH to infect cells

Article

Published on 2022-09-202022-11-15
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제,

Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen

Article

Published on 2022-09-072022-11-15
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 치료제,

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Article

Published on 2021-12-142022-10-31
Journal: Cell Discovery [Category] COVID-19,

SARS-CoV-2 and Implantation Window: Gene Expression Mapping of Human Endometrium and Preimplantation Embryo

Review

Published on 2021-12-102022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS‐CoV‐2

생체 내에서 ACE2 발현의 분자 PET/CT 프로파일 링 : SARS -COV -2의 감염 및 결과에 대한 시사점

Research Article

Published on 2021-06-262022-09-01
Journal: Advanced Science [Category] MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin‐converting enzyme 2 animal model approach binding causative agent clinical evaluation coronavirus disease Coronavirus disease 2019 COVID‐19 Critical determine disease entry receptor enzyme evaluated facilitate healthy volunteer healthy volunteers high affinity Human identify impacted IMPROVE in vitro infect cell infect cells infection process key factor model systems molecular molecular imaging MONITOR organ organs Patient peptide PET/CT positron emission Positron emission tomography positron emission tomography imaging Profiling provide Quantitative quantitative determination question radiolabeled Rapid receptor reported reproductive reproductive system Research respiratory SARS‐CoV‐2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus‐2 severity subject susceptible the patient tissue tomography translational Translational research unique whole body
[DOI] 10.1002/advs.202100965 PMC 바로가기 [Article Type] Research Article

Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression

Maackia amurensis seed lectin(MASL)이 SARS-CoV-2 감염 및 COVID-19 질병 진행을 억제할 가능성이 있는 구강 편평 세포에 다면발현 작용을 한다는 증거

Article

Published on 2021-06-012022-09-11
Journal: Experimental cell research [Category] SARS, 치료제,

[키워드] ACE2 ACE2 expression ACE2 protein ACE2 proteins ACE2 receptor addition agent Antiviral antiviral agent ARDS bind binding can be used caused Cell confirmed COVID-19 case COVID-19 COVID-19 disease COVID-19 patients Culture death decrease epithelial cell epithelial cells Express expression glycosylated glycosylation host cells identify infect infect cell Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inhibit inhibit SARS-CoV-2 international public health kidney lectin Maackia amurensis Modification oral oral mucosa Oral squamous cells pandemic pleiotropic progression Protein respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus sialic acid Spike protein squamous suppresse target the SARS-CoV-2 the SARS-CoV-2 virus viral-host interaction
[DOI] 10.1016/j.yexcr.2021.112594 PMC 바로가기 [Article Type] Article

Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

SARS-CoV-2 스파이크 단백질을 표적으로 하는 생물의학적 개입으로 인한 급격한 진화 탈출의 위험

Research Article

Published on 2021-04-282022-08-13
Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단,

[키워드] ACE2 affinity Analysis antibody antibody-based prophylactics comparable COVID-19 Critical Decay kinetics deleterious mutation develop domain epitope Epitopes escape mutant escape mutants expected focus Frequency Genetic variation Immune escape immune evasion Immunity immunization in vitro infect cell Intervention molecular molecular target Mutation NAb NAbs natural antigens natural immunity Neutral Neutralizing antibodies neutralizing antibody new strain overlap passive immunization Positive selection potential mechanism predict question raise raised raising RBD RBD-targeting nAbs SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 spike protein sequence Spike protein Strategy structure-function surveillance data the RBD therapeutic timeline Transmissibility vaccinal Vaccine Vaccines Viral Viral immune evasion virus virus escape neutralizing antibodies widespread wild type
[DOI] 10.1371/journal.pone.0250780 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 infection and smoking: What is the association? A brief review

Review

Published on 2021-03-232022-10-31
Journal: Computational and Structural Biotechnology Journal [Category] COVID-19,

[키워드] Abstract ACE-2 ACE2, Angiotensin-converting enzyme-2 ACEIs, Angiotensin‐converting enzyme inhibitors acute respiratory syndrome ADAM17, ADAM metallopeptidase domain 17 aggravate ALCAM, activated leukocyte cell adhesion molecule Ang, angiotensin angiotensin-converting enzyme-2 anticipated ARBs, angiotensin receptor blockers ARDS, acute respiratory distress syndrome association BatCoV, bat coronavirus CLDN7, claudin 7 Clinical course clinical manifestations COPD, Chronic obstructive pulmonary disease coronavirus coronavirus disease Coronaviruses correlation COVID-19 COVID-19, Coronavirus disease 2019 CTNNB1, catenin beta 1 described Disease progression Effect ENhance ERK, extracellular signal-regulated kinases expression expression of SARS-CoV-2 Genes HDAC6, histone deacetylase 6 HIV-1, human immunodeficiency virus 1 hrsACE2, human recombinant soluble ACE-2 IFN, Interferons increase induce infect cell infections Infectious disease IPF, Idiopathic pulmonary fibrosis IR, Ionizing radiation JNK, c-Jun N-terminal kinase knowledge less Lung disease MCN, mucin MERS, middle-East respiratory syndrome morbidity and mortality nAChR, α7 nicotinic acetylcholine receptor new strain NO, Nitric Oxide oral disease pandemic paradoxical R0, R-nought RAS, renin-angiotensin receptor Research Respiratory disease Respiratory illness risk risk factor RR, relative risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, severe acute respiratory syndrome coronavirus severity of COVID-19 shown smoking therapy TJP3, tight junction protein 3 TMPRSS, transmembrane serine protease TMPRSS2 transmembrane serine protease
[DOI] 10.1016/j.csbj.2021.03.023 PMC 바로가기 [Article Type] Review

Do Cellular Entry Mechanisms of SARS-Cov-2 Affect Myocardial Cells and Contribute to Cardiac Injury in COVID-19 Patients?

Physiology

Published on 2021-03-092022-10-31
Journal: Frontiers in Physiology [Category] COVID-19,

Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice

K18-hACE2 마우스에서 SARS-CoV-2의 비강내 접종 후 신경 침범 및 뇌염

Article

Published on 2021-01-192022-09-10
Journal: Viruses [Category] 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Brain brains Cell cell death Central nervous system characterized chemokines CNS Coronavirus-2 correlated COVID-19 cytokine Cytokines declined direct infection Encephalitis exhibited hACE2 hallmark hemorrhage highest humans infect cell Infection Infectious virus Inflammatory response inoculation intranasal K18-hACE2 K18-hACE2 mice leukocyte leukocyte infiltration lung Lungs mice Mortality nasal nasal turbinate Neuroinflammation neuroinvasion Neurological disease neuronal olfactory olfactory bulb Onset Pathogenesis pathogenesis of SARS-CoV-2 plaque-forming unit plaque-forming units respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 neuroinvasion severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe disease Viral virus titer virus titers
[DOI] 10.3390/v13010132 PMC 바로가기 [Article Type] Article