Insights on cross-species transmission of SARS-CoV-2 from structural modeling
구조 모델링에서 SARS-CoV-2의 종간 전파에 대한 통찰력
Research Article
[키워드] Accuracy
ACE2
ACE2 orthologs
ACE2 variant
ACE2 variants
acute respiratory syndrome
acute respiratory syndrome coronavirus
affinity-enhancing mutation
affinity-enhancing mutations
Amino acid
amino acid residue
amino acids
antiviral therapeutics
atomic level
benefit
blueprint
chicken
complement
computational modeling
Computational study
confirmed case
confirmed cases
Contact
coronavirus
country
Cross-species transmission
develop
disrupt
Drug development
experiments
explain
geographical distribution
global pandemic
help
highlight
host cell
host cell membrane
host receptor
Human
humans
in some
infect
Infection
infection cycle
infection process
insight
Interaction
investigated
key amino acid
key amino acids
key polar
Like
mice
molecular feature
non-conservative mutation
non-conservative mutations
not applicable
other coronaviruses
pandemic
predict
protein interactions
provide
question
receptor protein
respiratory
responsible
risk
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike protein
several ACE2 amino acid residues
several ACE2 ortholog
several ACE2 orthologs
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
species
Spike protein
structural framework
Structural properties
structural property
susceptible
the SARS-CoV-2
therapeutic purposes
Therapeutics
thought
three-dimensional structure
Transmission
transmitted
Viral
viral infection
viral infections
Viral protein
viral spike protein
viral-host protein interaction
viral-host protein interactions
viruses
widespread
wild animals
[DOI] 10.1371/journal.pcbi.1008449 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pcbi.1008449 PMC 바로가기 [Article Type] Research Article