Contact network analysis of COVID-19 Delta variant outbreak in urban China -based on 2,050 confirmed cases in Xi’an, ChinaCase Reports Published on 2022-12-222023-07-11 Journal: BMC Public Health [Category] COVID19(2023년), [키워드] Contact network COVID-19 delta variant Infection route Interval. [DOI] 10.1186/s12889-022-14882-3 PMC 바로가기 [Article Type] Case Reports
Characteristics of animal models for COVID-19Article Published on 2022-10-012022-11-16 Journal: Animal models and experimental medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome animal model animal models applied blueprint Characteristics coronavirus coronavirus disease COVID-19 develop disease establishment. Genome group hamsters Health Infection Infection route manifestation MERS-CoV mice Mutation pandemic Pandemics pathogen resource SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic transmission route unique variants of concern World Health Organization [DOI] 10.1002/ame2.12278 PMC 바로가기
SARS-CoV-2 requires acidic pH to infect cellsArticle Published on 2022-09-202022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제, [키워드] 3D imaging Acidic acidic pH acute respiratory syndrome cathepsin Cell cell entry cleavage coronavirus detect endosomal furin Genome infect cell Infection Infection route live-cell imaging membrane membrane fusion nasal occurred penetration producing SARS-CoV-2 target cells TMPRSS2 TMPRSS2-expressing cell virion virus entry [DOI] 10.1073/pnas.2209514119 PMC 바로가기
Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trialSARS-CoV-2에 대한 구강청결제 - 시험관 내 막 파괴에 의한 높은 항바이러스 효과는 무작위 위약 대조 임상 시험에서 약한 효과로 해석됩니다.Randomized Controlled Trial Published on 2022-07-152022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] Analysis antiseptic Antiseptic agents Antiviral Antiviral effect BAC benzalkonium Benzalkonium chloride can be used capsid Capsid protection assay Cell culture chloride clinical evaluation clinical evaluations COVID-19 disrupting Effect effective intervention evaluated human population in vitro inactivated Infection route Measures membrane Mild minor mouthrinse Mouthwash oral cavity placebo-controlled clinical trial qPCR Randomized reduce reduction respiratory RT-qPCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 subsequent translate Transmission transmission rate transmission rates Treatment variety viral envelope Viral load viral loads Viral RNA virus was used without affecting [DOI] 10.1016/j.virusres.2022.198791 PMC 바로가기 [Article Type] Randomized Controlled Trial
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1고용량 약물 스크리닝을 통해 SARS-CoV-2 Delta 및 Omicron/BA.1의 다양한 경로를 구체적으로 표적으로 하는 진입 억제제 식별 가능Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Alpha antagonist antagonists applied BA.1 Beta Caco2 cells Cathepsin-L cell entry cells cellular entry chlorpromazine Combination Compound D614G Delta drug Drug repurposing Drug screening Entry inhibitor FDA-approved drugs G protein G protein coupled receptor antagonist G-protein help highest identify Infection route inhibit inhibitors lentiviral Lentiviral vector lentiviral vectors mechanism membrane fusion omicron pathway phenothiazine preference pseudotyped pseudovirus pseudoviruses receptor receptor antagonist Receptor binding receptors respiratory responsible resulting SARS-CoV-2 several variant several variants Severe acute respiratory syndrome specific inhibitors spike variant synergistic targets TMPRSS2 variant variant of concern viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article
What We Are Learning from COVID-19 for Respiratory Protection: Contemporary and Emerging IssuesReview Published on 2021-11-282022-10-28 Journal: The British journal of oral & maxillofacial surger [Category] COVID-19, [키워드] addressed Asymptomatic biocidal material caused changes in Characteristics Compliance COVID-19 decontamination Diseases Efficacy evidence of filtration fit healthcare worker highlight Infection Infection route Interaction issue knowledge learning mechanisms pathogen pre-symptomatic Protective public health reduce respiratory Respiratory disease respiratory infectious disease respiratory protective device resulting RPD SARS-CoV-2 Transmission transmission rate Vaccines variant viability virus [DOI] 10.3390/polym13234165 PMC 바로가기 [Article Type] Review
Epidemiological Characteristics of COVID-19 Resurgence in Areas Initially Under ControlPublic Health Published on 2021-11-232022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Adequate analyzed Area Characteristics Chinese Contact Control Course COVID-19 described distribution Epidemic epidemiological Epidemiological characteristics family indigenous patient Infection Infection route information Initially Isolation management MONITOR Nosocomial infection occurred outbreak Outbreaks Patient patients Preventive strategy resurgence risk of infection symptomatic and asymptomatic symptomatic patient Transmission was collected [DOI] 10.3389/fpubh.2021.749294 PMC 바로가기 [Article Type] Public Health
Clinical characteristics of pregnant women with COVID-19 in Japan: a nationwide questionnaire surveyResearch Published on 2021-09-182022-10-28 Journal: BMC Pregnancy and Childbirth [Category] COVID-19, [키워드] acute respiratory syndrome Asymptomatic caesarean sections Characteristics clinical Clinical characteristics collected conducted coronavirus coronavirus disease country COVID-19 COVID-19 infection COVID‐19 death delivery diagnosed with COVID-19 died epidemiological examined FIVE gestation period incidence Infection Infection prevention Infection route Japan National outcome outcome measure Oxygen administration Pneumonia positive rate Pregnancy pregnant women questionnaire reported respiratory symptoms response Result risk factor route of infection SARS-CoV-2 SARS-CoV-2 transmission screening test severe cases Severe infection Symptom symptomatic Symptoms Transmission Treatment were assessed with COVID-19 women [DOI] 10.1186/s12884-021-04113-9 PMC 바로가기 [Article Type] Research
SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications비인간 영장류 모델에서 SARS-CoV-2 감염 및 질병 결과: 발전 및 의미Review Published on 2021-09-172022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] abnormality animal model benefit breathing difficulty catastrophic causative pathogen clinical symptom cough COVID-19 demonstrated develop diagnostic disease drugs Fever Health Host immune response Human hyperplastic immune response Immunopathogenesis implication infect Infection route lesion lung mechanism NHP NHP model NHP models non-human primate non-human primates outcome pandemic of COVID-19 resulting SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome translation Vaccine vaccine and drug discovery [DOI] 10.1080/22221751.2021.1976598 PMC 바로가기 [Article Type] Review
Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responsesArticle Published on 2021-08-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] activated Cell Cell Biology cell lines Comparative Computational biology and bioinformatics COVID-19 disease Critical disease status Diseases Endoplasmic reticulum Express expression level hACE2 HEK293T cell Host Host immune response human Angiotensin-converting enzyme immune attack immune response immune responses immunology infected cell Infection Infection route innate immune response mechanism Microbiology model system Molecular biology overexpress Pathogenesis pathway progression Protein provided reflect reveal robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severity of COVID-19 Stress Systems biology Transcriptome transcriptomic analysis triggering Viral load virus [DOI] 10.1038/s41598-021-96462-w PMC 바로가기 [Article Type] Article