Use of wastewater surveillance for early detection of Alpha and Epsilon SARS-CoV-2 variants of concern and estimation of overall COVID-19 infection burden우려의 알파 및 엡실론 SARS-CoV-2 변종 조기 감지 및 전체 COVID-19 감염 부담 추정을 위한 폐수 감시 사용Article Published on 2022-08-202022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] Alpha Amplicon analyzed B.1.1.7 B.1.429 Clinical data clinical testing Concentration COVID-19 COVID-19 incidence COVID-19 infection diagnostic diagnostic testing effective eight Epsilon expected fecal identify individual Infection infectious agents Lineage log Mutation quantification ranged reported RNA concentrations SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant Sequencing Seroprevalence several limitation several limitations significantly higher Surveillance surveillance data The United States trend United States variant variants variants of concern virus wastewater WGS whole genome Whole genome sequencing [DOI] 10.1016/j.scitotenv.2022.155410 PMC 바로가기 [Article Type] Article
The genetic and evolutionary determinants of COVID-19 susceptibilityCOVID-19 감수성의 유전적 및 진화적 결정 요인Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] admixture applied approach archaic humans cellular contribute Course COVID-19 COVID-19 illness COVID-19 susceptibility determinant disease disease susceptibility Diseases Ethnic groups event explain facilitated Factor Genetic Genetic predisposition Human genetics humans immunological immunological mechanism individual Infection infectious agents Infectious disease Infectious diseases knowledge molecular outbreak outcome Pandemics Pathogens Perspective recent finding recent findings reported SARS-COV-2 infection severity severity of COVID-19 susceptibility threat Threats Variability [DOI] 10.1038/s41431-022-01141-7 PMC 바로가기 [Article Type] Review
Neutralization against Omicron variant in transplant recipients after three doses of mRNA vaccinemRNA 백신 3회 투여 후 이식 수혜자에서 Omicron 변이체에 대한 중화Article Published on 2022-08-012022-09-11 Journal: American journal of transplantation : official jou [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] analyzed anti-RBD circulating completion COVID-19 vaccine Delta demographic variable Demographic variables detectable dominant dose heart immunogenicity Infection infection and infectious agents-viral: SARS-CoV-2/COVID-19 infectious agents Infectious disease kidney lentivirus liver log lung median mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 vaccine neutralization neutralizing antibody Neutralizing antibody response neutralizing response omicron Omicron variant Patient patients positive positive patient positive patients proportion pseudotyped recipient reduction SARS-CoV-2 spike SARS-CoV-2 virus significantly translational translational research/science undetectable Vaccine variant variants was determined wild-type wild-type virus [DOI] 10.1111/ajt.17020 PMC 바로가기 [Article Type] Article
No molecular evidence of SARS-CoV-2 infection in companion animals from Veracruz, Mexico멕시코 베라크루즈의 반려동물에서 SARS-CoV-2 감염의 분자적 증거 없음Article Published on 2022-07-012022-09-11 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] Active surveillance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach cats Chain Reaction close contact collected coronavirus COVID-19 detect dogs epidemiological epidemiological surveillance Evidence exposure to human populations imperative infectious agent infectious agents Latin America limit measure molecular N1 and N2 Nasopharyngeal swab nasopharyngeal swab sample oral organism Organisms pathogen Pathogens patients with COVID-19 polymerase chain polymerase chain reaction Population Prevent qPCR recent reduce reverse transcription reverse transcription polymerase chain reaction risk of transmission RNA RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shown species Surveillance susceptible tested Total total RNA Transmission Transmission dynamics transmitted viral gene viral genes viral infection was performed [DOI] 10.1111/tbed.14153 PMC 바로가기 [Article Type] Article
Pivoting Novel Exosome-Based Technologies for the Detection of SARS-CoV-2SARS-CoV-2 검출을 위한 새로운 엑소좀 기반 기술 활용Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acceleration Accessibility Accuracy approach approaches biochemical Biomarker cell-to-cell communication commercialization COVID-19 Critical detection diagnosis of COVID-19 diagnostic diagnostics ENhance EVs Exosome Exosomes Extracellular extracellular vesicle Extracellular vesicles focus implementation infectious agents Isolation molecular NIH novel physical Radical RADx Rapid SARS-CoV-2 SARS-CoV-2 viral infection SARS-CoV-2 virus subpopulation surveillance testing technology Viral viral infection [DOI] 10.3390/v14051083 PMC 바로가기 [Article Type] Review
Humoral immune responses against SARS-CoV-2 in transplantation: Actionable biomarker or misplaced trust?이식에서 SARS-CoV-2에 대한 체액 면역 반응: 실행 가능한 바이오마커 또는 잘못된 신뢰?Editorial Published on 2022-05-012022-09-11 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, [키워드] antibody antibody biology Biomarker cellular immune responses clinical care editorial/personal viewpoint immune immune modulation immune regulation immune response immune responses Immunosuppression immunosuppression/immune modulation Infection infection and infectious agents-viral: SARS-CoV-2/COVID-19 infectious agents Infectious disease measure required response SARS-CoV-2 SARS‐CoV‐2 Vaccine variants of concern [DOI] 10.1111/ajt.17018 PMC 바로가기 [Article Type] Editorial
ALVR109, an off-the-shelf partially HLA matched SARS-CoV-2-specific T cell therapy, to treat refractory severe COVID-19 pneumonia in a heart transplant patient: Case report심장 이식 환자의 난치성 중증 COVID-19 폐렴을 치료하기 위해 부분적으로 HLA와 일치하는 기성품인 SARS-CoV-2-특이적 T 세포 요법인 ALVR109: 사례 보고Case Reports Published on 2022-04-012022-09-11 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), SARS, 변종, [키워드] Administered administration antibiotic: antiviral Antiviral benefit Cell therapy Clinical improvement clinical research/practice clinical trials Corticosteroids COVID-19 Day declined delta variant diagnosis of COVID-19 discharged Heart transplantation heart transplantation/cardiology High-flow nasal oxygen HLA immunobiology Immunosuppression improvement IND Infection infection and infectious agents-viral: SARS-CoV-2/COVID-19 infectious agents Infectious disease initial log low-flow oxygen male mycophenolate mycophenolate mofetil nasopharyngeal nasopharyngeal viral oxygen Patient Prednisone Quantitative rejection Remdesivir request rising RNA SARS-CoV-2 delta SARS-CoV-2 RNA Severe COVID-19 pneumonia subsequent T cell tacrolimus the patient therapy Tocilizumab transitioned treat treated undetectable variant Viral load [DOI] 10.1111/ajt.16927 PMC 바로가기 [Article Type] Case Reports
Barriers and facilitators to infection prevention and control in Dutch psychiatric institutions: a theory-informed qualitative studyResearch Published on 2022-03-112022-10-28 Journal: BMC Infectious Diseases [Category] Coronavirus, [키워드] adopted antimicrobial resistance approach approaches barrier Care Characteristics Compliance conducted contribute COREQ COVID-19 criteria Data analysis equipment facilitate facilitator Factor FIVE Healthcare-associated infection hospitals identify implementation IMPROVE Infection prevention Infection prevention and control infectious agents Interaction knowledge limitation Mental mental health mental health care mental health services multidimensional Nosocomial infection outbreak professional Psychiatric psychiatry Qualitative qualitative study recommendation reported Reporting required Research resource responsible Result Spread strongly related supplementary material Support the patient thematic analysis Transmission unique [DOI] 10.1186/s12879-022-07236-2 PMC 바로가기 [Article Type] Research
The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infectionsReview Published on 2022-03-082022-10-28 Journal: PLoS Neglected Tropical Diseases [Category] COVID-19, [키워드] acute viral infection animal animal challenge studies anticipated Antiviral antiviral activity approval approved Biological breadth caused CFR Chemical clinical clinical benefit clinical development clinical evaluation clinical study conducted coronavirus 2 COVID-19 development disease drug drugs targeting Ebola Ebola virus Ebola virus disease Efficacy effort enzyme Evidence examined example facilitated FDA feasible Fever filoviruses food GS-5734 Hemorrhagic high-consequence pathogen highlight Hospitalization humans include Infection infectious agents inhibitor Laboratory testing Level 4 mechanism medical countermeasure NHP NHPs numbers of patient office outbreak outcome pandemic pathogen pathway Patient performed Prevent Program randomized clinical trials randomized, controlled trial RCTs Regulatory regulatory pathway Remdesivir Research respiratory RNA virus RNA-dependent RNA polymerase robust rule Safe SARS-CoV-2 severe disease Support therapeutic therapy treat Treatment Trial Vaccine viral infection viral pathogen viral replication virus virus infection while [DOI] 10.1371/journal.pntd.0010220 PMC 바로가기 [Article Type] Review
3D modelling and simulation of the dispersion of droplets and drops carrying the SARS-CoV-2 virus in a railway transport coachArticle Published on 2022-03-072022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] accounted approach carried CFD Computational fluid dynamics coughing Critical distribution droplet droplets Engineering evaluate Face mask feasibility Health care infectious agents Mathematics and computing offer outcome pandemic physically recommendation Release seated secretion the SARS-CoV-2 virus Transmission Transport variety Ventilated Ventilation virus while [DOI] 10.1038/s41598-022-08067-6 PMC 바로가기 [Article Type] Article