inflammatory protein – Communicable Diseases Research

Plasma biomarkers for systemic inflammation in COVID-19 survivors

Article

Published on 2022-09-012022-11-15
Journal: Proteomics. Clinical applications
[Category] SARS, 바이오마커,

Association of extracellular vesicle inflammatory proteins and mortality

세포외 소포 염증 단백질과 사망률의 연관성

Article

Published on 2022-08-182022-09-11
Journal: Scientific Reports
[Category] 바이오마커,

Evaluation of a potential prognostic parameter for the inflammatory status in COVID-19 patients: The inflammatory protein ratio

COVID-19 환자의 염증 상태에 대한 잠재적인 예후 매개변수 평가: 염증 단백질 비율

Article

Published on 2022-08-012022-09-11
Journal: Electrophoresis
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] albumin all the patients ANOVA C-reactive protein calculated Chain Reaction controls coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient CRP D-dimer dimer fibrinogen Globulin hospitalized patient Human plasma immuno-turbidimetric assay immunoassay Inflammatory inflammatory protein inflammatory state inflammatory status Interpretation involved Kruskal-Wallis mathematical Nasopharyngeal swab nasopharyngeal swabs parameter parameters Pearson performed polymerase chain polymerase chain reaction prognostic proportionality Protein qualitative test quantified real time real time Polymerase Chain Reaction RNA RT-PCR SARS-CoV-2 SARS-CoV-2 positivity separated Serum protein serum protein electrophoresis. serum proteins Significant significantly Spearman the patient unique variance
[DOI] 10.1002/elps.202100396 PMC 바로가기 [Article Type] Article

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells
[Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells mesenchymal stem cells. MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Shared Inflammatory Pathology of Stroke and COVID-19

뇌졸중 및 COVID-19의 공유 염증 병리학

Review

Published on 2022-05-052022-09-12
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), MERS, SARS, 진단,

Relationship between gene expression patterns from nasopharyngeal swabs and serum biomarkers in patients hospitalized with COVID-19, following treatment with the neutralizing monoclonal antibody bamlanivimab

중화 단일클론항체 밤라니비맙 치료 후 코로나19로 입원한 환자의 비인두 면봉 유전자 발현 패턴과 혈청 바이오마커 간의 관계

Randomized Controlled Trial

Published on 2022-03-182022-09-11
Journal: Journal of Translational Medicine
[Category] SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술,

[키워드] absence Analysis Analytes antibody formation Antibody Response approach bamlanivimab Biomarker biomarker signature Biomarkers Blood change changes in circulation clinical clinical trial Cohort collected connection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 CXCL10 CXCL11 detect disease Elecsys Gene Expression gene expression pattern groups healthy control healthy controls Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients IFNγ IgA IgG titer IgG titers IgM IL-6 immune response immunoassay immunological implementation Infection Inflammatory inflammatory protein Inflammatory response interferon response Level Luminex MCP-3 MONITOR monoclonal antibody nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples nasopharyngeal swabs Neutralizing not affect not significantly different observation observations Patient patient population patients patients hospitalized patients with COVID-19 peaked Peripheral blood Placebo presence or absence profile Protein Randomized receive reductions reductions in relationship remained repeated measure respiratory RNA sequencing RNA-Seq RNA-seq. SARS-CoV-2 SARS-COV-2 infection Seroconversion serology serum serum biomarker Serum protein serum proteins serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarities single dose systemic disease therapeutic Treatment Treatment strategies utility viral-induced was performed was used were used while with COVID-19
[DOI] 10.1186/s12967-022-03345-3 PMC 바로가기 [Article Type] Randomized Controlled Trial

Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury

급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘

Article

Published on 2022-03-012022-08-31
Journal: Journal of ethnopharmacology
[Category] MERS, SARS, 비임상, 치료제,

[키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting
[DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article

Senolytics reduce coronavirus-related mortality in old mice

Article

Published on 2021-11-162022-10-28
Journal: Science (New York, N.y.)
[Category] COVID-19, Fulltext, MERS,

[키워드] accumulate acute respiratory syndrome adverse outcome age amplify amplifying antibody Antibody Response Antiviral antiviral antibodies antiviral gene Apoptosis approach asked biopsies blunt caused Cell cell fate cells cellular cellular senescence changes in chronic disease Chronic diseases chronic inflammation Complete contribute coronavirus COVID-19 COVID-19 pandemic Cytokine storm Dasatinib decrease Defense drug dysfunction Effect elicited eliminated endothelial ENhance event expression Factors Gene Expression Genetic Human human cell human lung hyperinflammation Hyperinflammatory Hypothesis IFITM immune response IMPROVE in vivo increase increase in increased expression increased risk individual Infection Inflammation Inflammatory marker inflammatory protein LPS Lung epithelial cells mechanism metabolism MHV mice microbial morbidity and mortality morphology Mortality mouse hepatitis virus multi-organ failure obesity occur organ organism outcome PAMP PAMPs paracrine pathogen pathogen-associated molecular pathogen-associated molecular pattern pathogenic phenotype pro-inflammatory pro-inflammatory factors PROTECT Protein protein expression reduce reduce mortality reduced reducing regimen Resilience response resulting SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike SARS-CoV-2 spike protein SASP secrete Secretome senescence senescent senescent cell serum significantly significantly increased SPF Stress Support susceptibility targeting tissue transferred treat treated treating viral entry viral infection viral pathogen β-coronavirus
[DOI] 10.1126/science.abe4832 PMC 바로가기 [Article Type] Article

Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donors

Original Article

Published on 2021-08-062022-10-30
Journal: Immunity, Inflammation and Disease
[Category] COVID-19, MERS, SARS,

[키워드] activated T cell activated T cells activating acute respiratory syndrome Analysis analyzed B cell B‐cell Biliary CCR2 CD8 cellular response chemotactic convalescent plasma coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CX3CR1 cytokine cytokine production Cytokines disease Donor endothelial expected expression flow cytometry group growth healthy individual healthy subjects IL‐6 Immune cell immune cells immune response Immunity Infection infiltration Inflammatory marker inflammatory monocyte inflammatory protein inhibitory Leptin Ligand Lung injury Macrophage main mechanism Migration Mild MIP moderate monocyte Monocyte activation Monocytes New Patient patients performed Plasma cytokine positive Protein Proteins proteomics receptor recovered patient recovered patients recruited reduction in Result Saa1 serum significant increase sustained T cells target tissue Vascular
[DOI] 10.1002/iid3.476 PMC 바로가기 [Article Type] Original Article

Genetic risk for severe COVID‐19 correlates with lower inflammatory marker levels in a SARS‐CoV‐2‐negative cohort

Original Article

Published on 2021-06-062022-10-31
Journal: Clinical & Translational Immunology
[Category] COVID-19,

[키워드] acute respiratory syndrome Adaptive immune response Affect age Alpha applied association baseline baseline level Blood Blood level body mass index Cohort coronavirus coronavirus disease COVID‐19 COVID‐19 patients COVID‐19 cytokine Effect electrochemiluminescence method endothelial explain genetic risk genetic risk score genotype data growth factor hypothesise IFN‐γ IFN‐γ increasingly individual Infection Inflammation Inflammatory Inflammatory marker inflammatory markers inflammatory protein Innate immunity interferon gamma marker Necrosis obesity objective overactive profile reduced Result risk SARS‐CoV‐2 SARS‐CoV‐2 serum Support susceptibility susceptible the cytokine storm TNF‐α TNF‐α variable Vascular
[DOI] 10.1002/cti2.1292 PMC 바로가기 [Article Type] Original Article