Ingenuity Pathway Analysis – Communicable Diseases Research

Molecular evidence for suppression of swimming behavior and reproduction in the estuarine rotifer Brachionus koreanus in response to COVID-19 disinfectants

Article

Published on 2022-02-012023-07-08
Journal: Marine pollution bulletin [Category] COVID19(2023년),

Meta-Analysis of APP Expression Modulated by SARS-CoV-2 Infection via the ACE2 Receptor

Article

Published on 2022-01-212022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] ACE2 acute respiratory syndrome affected Alzheimer’s disease Alzheimer’s disease amyloid-beta precursor protein angiotensin-converting enzyme-2 app binding canonical caused characterized cleavage conducted core coronavirus Coronavirus-2019 COVID-19 downregulated exacerbating expression Infection Inflammation Ingenuity Pathway Analysis investigated involved IPA less Meta-analysis modulation Neuroinflammation P -value pathway plaque precursor progression Protein receptor resulting SARS-CoV-2 severe acute respiratory syndrome-coronavirus-2 signaling pathway upregulated upregulation upstream virus Z-score
[DOI] 10.3390/ijms23031182 PMC 바로가기 [Article Type] Article

Identification of the Key Immune-Related Genes in Chronic Obstructive Pulmonary Disease Based on Immune Infiltration Analysis

면역 침윤 분석을 기반으로 한 만성 폐쇄성 폐 질환의 주요 면역 관련 유전자 식별

Article

Published on 2022-01-042022-09-11
Journal: International journal of chronic obstructive pulmo [Category] SARS, 유전자 메커니즘,

[키워드] activated AHNAK Algorithm Analysis biological processe Biomarker cause of death chronic chronic obstructive chronic obstructive pulmonary disease CIBERSORT complex mechanism conducted COPD coronavirus disease coronavirus disease COVID-19 correlation Correlation analysis correlations CXCR1 CXCR2 database dataset death defined DEGs dendritic cell dendritic cells Diagnosis diagnostic biomarker Diagnostic biomarkers differentially expressed gene Differentially expressed genes downloaded enrichment analysis expressed FCGR3B follicular fraction Fractions Functional enrichment analyses Functional enrichment analysis Gene ontology Genes greater helper T cell hub genes identification Immune cell immune cells immune-related gene immune-related genes immune-related genes. Ingenuity Pathway Analysis Interaction investigated IPA IRGs KEGG Kyoto lung tissue morbidity neutrophil Neutrophils NK cells Obstructive obstructive pulmonary disease pathway Pathways Patient potential mechanism PPI progression proportion proportions protein-protein interaction pulmonary pulmonary disease significantly SLIT2 subset T cells Treatment
[DOI] 10.2147/COPD.S333251 PMC 바로가기 [Article Type] Article

Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 Infection

SARS-COV-2 감염 후 아밀로이드 전구체 단백질 발현의 변화에 대한 네트워크 메타 분석

Meta-Analysis

Published on 2021-12-012022-08-31
Journal: Journal of neuroimmune pharmacology : the official [Category] MERS, meta-analysis, SARS, 유전자 메커니즘,

[키워드] ACE2 Alzheimer’s disease amyloid amyloid precursor protein analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 app attachment base binding Blood–brain barrier Brain Brain microvascular endothelial cells canonical change complex COVID-19 COVID-19 disease elevated endothelial Endothelial cell endothelial cells enzyme expression followed by Host Host immune response host response identify IFNg IL1β IL6 immune response immune responses Implications incidence Infection Ingenuity Pathway Analysis inhibit inhibiting IPA knowledge base lead Meta-analysis modulated molecular mechanism molecular mechanisms molecules network Neuroinflammation neurological neurological manifestation p value pathway Protein Protein binding regulated Regulation reported resulting S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein Stat1 STAT3 statistically significant stroke TNF upstream were used with COVID-19 Z-score
[DOI] 10.1007/s11481-021-10012-9 PMC 바로가기 [Article Type] Meta-Analysis

Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs

중증 COVID-19 질환 환자의 폐에서 세포내 보체의 활성화는 폐의 T-세포 활성을 감소시킵니다

Immunology

Published on 2021-11-242022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Activation activity acute respiratory syndrome coronavirus alleviate Asymptomatic bioinformatics cellular and molecular Cellular and molecular mechanisms classical complement Complement activation conducted coronavirus coronavirus 2 COVID-19 COVID-19 patients decrease disease pathology disease severity downregulation Effect examined help Ingenuity Pathway Analysis Intracellular knowledge lung lung cell lung cells Lung pathology Lungs mechanical ventilator mechanism modulation multi-organ failure Novel coronavirus potential mechanisms proinflammatory reduce respiratory respiratory distress responsible RNA sequencing data SARS-CoV-2 SARS-COV-2 infection sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease severe COVID-19 patients Severe respiratory distress Support survival T-cell T-cells Treatment upregulation
[DOI] 10.3389/fimmu.2021.700705 PMC 바로가기 [Article Type] Immunology

Identification of serum prognostic biomarkers of severe COVID-19 using a quantitative proteomic approach

정량적 단백질 학적 접근법을 사용하여 심한 코비드 -19의 혈청 예후 바이오 마커의 확인

Article

Published on 2021-10-192022-08-31
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료법,

[키워드] acquisition approach best Biomarkers Cardiovascular disorders characterized CHI3L1 Clinical prognosis COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 prognosis cytokine cytokine signaling determine diagnostic differential expression differentially expressed ELISA assay evaluated Health help identification identify IGFALS IL-6 implicated Ingenuity Pathway Analysis interleukin introduced mass spectrometry Necrosis Patient predicted predictor Prognosis prognostic biomarker Prognostic factor Prognostic factors Prognostic markers progression Protein proteomic Proteomic analysis Quantitative regulated serum Serum protein serum proteins severe COVID-19 severe COVID-19 patients severe disease severely ill COVID-19 patients systemic inflammatory response the disease TNF Treatment Tumor tumor necrosis tumor necrosis factor viral infection with COVID-19
[DOI] 10.1038/s41598-021-98253-9 PMC 바로가기 [Article Type] Article

Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium

인간기도 상피에서 SARS-COV-2 유도 유전자 시그니처의 통합 메타 분석에 기초한 COVID-19에 대한 약물 용도

Research Article

Published on 2021-09-282022-09-10
Journal: PLoS ONE [Category] SARS, 신약개발, 치료제,

[키워드] activated acute respiratory syndrome Algorithm Algorithms ALPL Anti-viral approved Biomarker candidate canonical CCL20 CLC clinical trial clinical trials coronavirus coronavirus 2 COVID-19 COVID-19 pathogenesis COVID-19 treatment CSF3 CXCL1 CXCL10 CXCL8 database differentially expressed gene drug Drug repurposing drug target drugs effective intervention epithelial cells FDA gene network gene networks gene signature Genomics Human airway epithelium IL6 independent indications Infection inflammatory pathways information Ingenuity Pathway Analysis inhibit IPA list log2FC Meta-analysis pathway primary human airway Primary human airway epithelial cells Protein Qiagen regulate respiratory RNA sequencing SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severe acute respiratory syndrome-related coronavirus 2 target targets Treatment Trial
[DOI] 10.1371/journal.pone.0257784 PMC 바로가기 [Article Type] Research Article

Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies

COVID-19 병리학에서 팔미트산 증대의 분자 메커니즘

Article

Published on 2021-07-012022-09-12
Journal: International Journal of Molecular Sciences [Category] SARS, 진단,

[키워드] ACE2 Activation Affect affected apoptotic attenuate augmentation base Biological biological molecules canonical CCL2 CCL5 Cell cell surface receptor chemokines claimed coronavirus disease Coronavirus disease 2019 coronavirus pathogenesis COVID-19 COVID-19 pathology Cytokines dataset EEF1A1 elevated exacerbate expression Fatty acid fatty acids FFA FFAs free fatty acid free fatty acids IL1β Inflammatory mediators Ingenuity Pathway Analysis inhibiting knowledge base modulate molecular mechanism molecular mechanisms Mortality n-3 fatty acid NFκB obese obesity palmitic acid pandemic Pathologies pathway progression PTGS2 retrieved SARS-CoV-2 spike protein severity Spike protein subjects surface receptor the SARS-CoV-2 transcription factors translation were used
[DOI] 10.3390/ijms22137127 PMC 바로가기 [Article Type] Article

Network Meta-Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 Pathologies

COVID-19 병리의 알코올 증강의 기본 메커니즘에 대한 네트워크 메타 분석

Meta-Analysis

Published on 2021-04-012022-08-31
Journal: Alcoholism, clinical and experimental research [Category] MERS, meta-analysis, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected alcohol alcohol consumption Analysis anti-inflammatory mediator anti-inflammatory mediators augmentation base bioRxiv caused cellular metabolism changes in clinician conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine Cytokines dataset early phase Effect ENhance Ethanol EtOH Fever fibrosis Gene Expression gene expression profile GEO GEO database glucocorticoid Glucocorticoid receptor hepatic fibrosis HMGB1 homeostasis hyperinflammatory phase IL-1 IL-1β IL-6 IL-6 signaling pathways Inflammation Inflammatory mediators Ingenuity Pathway Analysis Ingenuity Pathway Analysis. inhibiting IPA JUN knowledge base lung mapped mediators Meta-analysis metabolism molecule molecules network Network meta-analysis Neuroinflammation pandemic Pathologies pathway Pathways Patient predicted receptor respiratory retrieved risk RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins sequencing data severe acute respiratory syndrome Coronavirus signaling pathway STAT systemic inflammation TNF transcription factors Viral viral infections worldwide crisis
[DOI] 10.1111/acer.14573 PMC 바로가기 [Article Type] Meta-Analysis

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysis

Research Paper

Published on 2021-01-012022-10-29
Journal: International Journal of Medical Sciences [Category] COVID-19, MERS,

[키워드] A549 ACE2 acute respiratory distress acute respiratory syndrome alteration Analysis angiotensin-converting enzyme 2 annotation applied approach bioinformatics caused cells clinical manifestation complement contribute controls coronavirus CoV COVID-19 CoVs current diagnose disease distress dysregulation effective enrichment epithelial exacerbate Gene Expression Gene ontology gene signature Genetic host cell immune system in silico induce Infection Ingenuity Pathway Analysis interferon kill Lung epithelial cells medication NHBE overexpression pandemic pathogenic coronavirus pathway Pathways performed receptor signaling Research response RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell severely ill patients syndrome target upregulated gene Venn diagram Visualization were infected
[DOI] 10.7150/ijms.52256 PMC 바로가기 [Article Type] Research Paper