Acriflavine and proflavine hemisulfate as potential antivirals by targeting MproArticle Published on 2022-12-012022-11-15 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] ACF acriflavine activity addition anti-SARS-CoV-2 Antiviral antiviral target BHK-21 cell Compound Coronaviruses demonstrated effective drugs effort enzymatic assay experiment HCoV-OC43 in vitro Infection inhibited inhibitor inhibitors inhibitory activity M pro M(pro) inhibitor MPro Proflavine Proflavine hemisulfate Remdesivir Replication reported SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 virus SARS-CoV-2. Transcription Viral RNA [DOI] 10.1016/j.bioorg.2022.106185 PMC 바로가기
The inhibitory activity of methoxyl flavonoids derived from Inula britannica flowers on SARS-CoV-2 3CLproArticle Published on 2022-12-012022-11-15 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro concentrations coronavirus effective effort exhibited flavonoid HCoV-OC43 Hydrogen bond identify inhibited inhibitor inhibitory activity Inula britannica key amino acid Methoxyl flavonoids molecular simulations natural antiviral nuclear proliferation SARS- CoV-2 SARS-CoV-2 SARS-CoV-2. Structure suppressed [DOI] 10.1016/j.ijbiomac.2022.10.008 PMC 바로가기
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targetsArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CL pro 3CLpro acting antiviral activity approach approach binding binding free energy complex COVID-19 dimeric docked complexes docking explained FDA-approved drug FIVE heterodimeric Host in vitro activity inhibit inhibitor inhibitory activity Ivermectin MD simulation molecular molecular docking Molecular dynamics simulation molecular dynamics simulation. molecular mechanism nuclear previous study protease Proteins reached Replication responsible SARS-CoV-2 SARS-CoV-2 replication shown Structural analysis structural property target translocation variety virus with COVID-19 [DOI] 10.1080/07391102.2021.1911857 PMC 바로가기
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
Synthesis and Anticancer and Antiviral Activities of C-2′-Branched ArabinonucleosidesArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activity Analysis anti-SARS-CoV-2 anti-tumor Antiviral antiviral activity Cell cell line Concentration coronavirus cytotoxicity Effect functional Generation time group growth HaCaT immortalized inhibitory activity investigated morphological changes MTT nucleoside nucleoside analogue outcome parameter photocatalytic thiol-ene reaction Reactions SAR SARS-CoV-2 SCC synthesis time-lapse imaging. tumor cells tumorous was obtained [DOI] 10.3390/ijms232012566 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin furin. generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV InfectionArticle Published on 2022-10-152022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] Act acute diarrhea anticancer Antiviral antiviral strategy cause caused cellular cellular translation Concentration coronavirus cytoskeleton. drug effective epidemic diarrhea family Coronaviridae high mortality host cell inhibited inhibitor inhibitory activity magnitude Newborn PEDV pseudotyped RAF265 reduced reduced viral load Replication shown starting point translation treat Vero cells viral entry viral infection Viral vector virus vomiting [DOI] 10.3390/v14102261 PMC 바로가기
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR StudiesArticle Published on 2022-10-132022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Anticoagulant Anticoagulants carried Compound compounds conducted COVID-19 cytotoxicity demonstrated drug Dynamics eligible enzyme highest highest binding affinity Idraparinux in silico in silico approaches in vitro in vitro. inhibitory inhibitory activity inhibitory concentration intrinsic investigated M pro molecular molecular docking MPro MTT performed Potential protease reference standard SAR SARS-CoV-2 SARS-CoV-2 Mpro screened sodium the SARS-CoV-2 thermodynamic [DOI] 10.3390/ijms232012235 PMC 바로가기
(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 VirusesArticle Published on 2022-09-292022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] acid Antiviral antiviral action antiviral activity Antiviral compound binding site Compound compounds Delta derivative exhibit glycoprotein hemoglobin inhibitory activity main viral protease 3CLPro mechanism metabolite molecular Molecular modeling N-terminal domain omicron performed protease SARS-CoV-2 SARS-CoV-2 virus shown Spectrum strain Strains Surface glycoprotein surface glycoprotein S usnic acid virus virus SARS-CoV-2. Wuhan [DOI] 10.3390/v14102154 PMC 바로가기
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in IcelandArticle Published on 2022-09-282022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] antibody binding BNT162b2 booster booster vaccination Combination Delta delta variant Effect greater Iceland infections inhibitory activity initiated majority mRNA mRNA vaccine mRNA-1273 observé omicron qPCR test reflected risk risk of infection SARS-CoV-2 infections SARS-CoV-2 variant Spread vaccination vaccination against COVID-19 vaccination schedule Vaccine virus [DOI] 10.1038/s41467-022-33076-4 PMC 바로가기