Long-Lasting Enhanced Cytokine Responses Following SARS-CoV-2 BNT162b2 mRNA VaccinationArticle Published on 2024-07-032024-09-05 Journal: Vaccines [Category] update2024, [키워드] cytokine responses Inflammatory responses innate immune memory mRNA vaccine proteomics [DOI] 10.3390/vaccines12070736 PMC 바로가기 [Article Type] Article
Trained immunity-related vaccines: innate immune memory and heterologous protection against infectionsReview article Published on 2022-04-212022-10-05 Journal: Trends in molecular medicine [Category] 비임상, [키워드] Adaptive immune response BCG build cellular and molecular classical COVID-19 Effect feature Heterologous heterologous effects Immunity induce Infection innate immune memory innate immune response innate immune system mechanism memory Pandemics pathogen Pathogens resulting suggested trained immunity triggered Vaccine Vaccines [DOI] 10.1016/j.molmed.2022.03.009 [Article Type] Review article
Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in miceBCG 및 DTPw 백신으로 면역 접종을 하면 쥐에서 훈련된 면역의 서로 다른 프로그램이 유도됩니다.Article Published on 2022-03-082024-08-18 Journal: Vaccine [Category] 백일해, 파상풍, [키워드] dendritic cells innate immune memory trained immunity vaccination Vaccine nonspecific effects. [DOI] 10.1016/j.vaccine.2021.03.084
Two Faces of Macrophages: Training and ToleranceReview Published on 2021-11-022022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] association Autoimmune disorders Cancer Defense detect Epigenetic epigenetics face Factor homeostatic Host human diseases illnesses Inflammatory diseases initial innate immune memory investigated involved Macrophage macrophages metabolic pathway molecular mechanism Pathogenesis respond Sepsis Signaling tissue tissue microenvironment tissues Tolerance trained immunity training wound healing [DOI] 10.3390/biomedicines9111596 PMC 바로가기 [Article Type] Review
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19Article Published on 2021-06-162022-11-01 Journal: EMBO Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] adaptive cause convalescent COVID‐19 COVID‐19 patient COVID‐19 patients Epigenetic gene expression signature healthy hyperinflammation Hyperinflammatory syndrome Immunity immunology in vivo Inflammasome inflammasome activation Innate innate immune innate immune memory Innate immunity longitudinal analysis Macrophage Microbiology, Virology & Host Pathogen Interaction Modification monocyte naïve individuals NLRP3 patients responsible resulting robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 secretion Signaling Spike protein subset Surface glycoprotein transcriptional Trigger vaccine antigen viral control [DOI] 10.15252/emmm.202114150 PMC 바로가기 [Article Type] Article
The BCG Vaccine for COVID-19: First Verdict and Future DirectionsImmunology Published on 2021-03-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome administer Administered bacille Calmette-Guérin BCG BCG vaccination bcg vaccine Care catastrophic characterized clinical trials coronavirus cost-effective intervention country cross-protection cross-protective decrease direction Diseases dose Effect effort Epigenetic explained Future Health health system highlighting immune responses Immunity inflammatory cytokine production innate immune memory Macrophage mitigate offer overcome pandemic Prophylactic proportion reported respiratory infections respiratory infectious disease SARS-CoV-2 SARS-COV-2 infection Sickness the vaccine this new coronavirus trained immunity Treatment Tuberculosis vaccinate vaccination Vaccine vaccine for COVID-19 [DOI] 10.3389/fimmu.2021.632478 PMC 바로가기 [Article Type] Immunology
Bacillus Calmette-Guerin (BCG): the adroit vaccineReview Published on 2021-02-082022-10-27 Journal: AIMS Microbiology [Category] COVID-19, [키워드] Activation all-cause mortality approach Bacillus Calmette-Guérin BCG clinical trial correlation COVID-19 COVID-19 pandemic COVID-19 transmission disseminated tuberculosis Effect Effects Efficacy epidemiological Epidemiological study Evidence Fever form H1N1 herpes simplex Heterologous highlight Host HPV human vaccine humans implication Infants influence Influenza virus innate immune memory investigated mechanism mortality rate Neonatal non-specific non-specific effects, vaccine objective offered papilloma protective effect pulmonary tuberculosis reduce Research respiratory syncytial virus Result RSV significantly subject suggested the vaccine thought Tuberculosis vaccination Vaccination strategy Vaccine viral infection viral infections virus while [DOI] 10.3934/microbiol.2021007 PMC 바로가기 [Article Type] Review
Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19Mini review Published on 2021-01-092022-10-05 Journal: Trends in endocrinology and metabolism: TEM [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] Activation Altered binding cells cholesterol cholesterol synthesis coronavirus disease COVID-19 Cytokine storm Inflammation innate immune memory Lipid lipid metabolism lipid synthesis obesity patients with obesity recent regulatory element severe COVID-19 synthesis Trigger [DOI] 10.1016/j.tem.2021.01.001 [Article Type] Mini review
Overcoming immune dysfunction in the elderly: trained immunity as a novel approachInvited Review Published on 2020-12-072024-09-04 Journal: International Immunology [Category] 대상포진, [키워드] aging immunosenescence inflammaging innate immune memory vaccination [DOI] 10.1093/intimm/dxaa052 PMC 바로가기 [Article Type] Invited Review
Hydroxychloroquine Inhibits the Trained Innate Immune Response to InterferonsArticle Published on 2020-11-102022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Antiviral block Blood Candida cellular changes in Chloroquine conditioned coronavirus coronavirus disease COVID-19 COVID-19 patient dampen decreased expression Genes healthy donor Hydroxychloroquine Immunity Infection inhibit Innate innate immune innate immune cell innate immune memory innate immune response Innate immunity interferon interferon response interferon-stimulated genes interferons investigated leukocyte Ligand ligands lipidome lysine mechanism of action Modification modifications Monocytes mononuclear cell Patient patients PBMC PBMCs peripheral Peripheral blood Prophylactic receptor response SARS-CoV-2 SARS-COV-2 infection the interferon trained immunity [DOI] 10.1016/j.xcrm.2020.100146 PMC 바로가기 [Article Type] Article