A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and replicationOriginal Article Published on 2024-05-242024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] ACE2 cathepsin B cell-penetrating peptide COVID-19 Integrins MT: Oligonucleotides: Therapies and Applications RGD RNAi SARS-CoV-2 siRNA [DOI] 10.1016/j.omtn.2024.102227 PMC 바로가기 [Article Type] Original Article
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8article Published on 2023-09-132024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Cryoelectron microscopy Integrins Protein design [DOI] 10.1038/s41467-023-41272-z PMC 바로가기 [Article Type] article
ICAMs are dispensable for influenza clearance and anti-viral humoral and cellular immunityArticle Published on 2023-02-212023-06-14 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] Endothelium Inflammation Integrins leukocyte trafficking memory [DOI] 10.3389/fimmu.2022.1041552 PMC 바로가기
Comparative Assessment of the Inhibitory Potential of the Herbicide Glyphosate and Its Structural Analogs on RGD-Specific Integrins Using Enzyme-Linked Immunosorbent AssaysArticle Published on 2022-10-172022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation AMPA assessment binding biochemical Cell Comparative demonstrated derivative ECM ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Extracellular matrix fibrinogen glycoprotein glyphosate Herbicide ingredient inhibition inhibitory effect integrin Integrins integrins αVβ3 metabolite metabolites pathway physiological functions Polymer Potential Protein Receptor binding domain SARS-CoV-2 receptor SARS-COV-2 receptor binding domain Spike protein structural analogs the SARS-CoV-2 Total α5β1 αllbβ3. [DOI] 10.3390/ijms232012425 PMC 바로가기
Natural killer cell homing and trafficking in tissues and tumors: from biology to application Reviews Published on 2022-06-292022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] Affect Allogeneic Alter blood circulation Bone marrow Cancer Cancer immunotherapy cancer treatment cancers CAR cells cellular chemokine chemokine receptors chimeric antigen receptor clinical utility cytokine Cytokines Defense develop Evidence Ex vivo expansion Factor Factors homing Immunotherapy IMPROVE infiltration Innate lymphoid cells Integrins limit lymphoid organs lymphoid tissues mechanism microenvironment natural natural killer cell NK cell peripheral tissues profile receptors solid tumors Steady state subset tissue transcriptional transfer transferred Treatment [DOI] 10.1038/s41392-022-01058-z [Article Type] Reviews
Integrins as Therapeutic Targets for SARS-CoV-2SARS-CoV-2의 치료 표적으로서의 인테그린Article Published on 2022-04-292022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료제, [키워드] Abstract ATN-161 cilengitide Integrins RGD SARS-CoV-2 target therapeutic [DOI] 10.3389/fcimb.2022.892323 PMC 바로가기 [Article Type] Article
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 InfectionSARS-CoV-2 감염 시 인테그린과 캐드헤린 간의 분자 상호작용으로 혈관 장벽 무결성 상실Article Published on 2022-04-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] abnormal coagulation barrier cadherin candidate cilengitide complex Complication contribute COVID-19 Cytokine storms dysregulation Effects elicit endothelial endothelial cells Endothelial dysfunction Endotheliitis event events expressed Extracellular homeostasis Hypoxemia inhibitor integrin integrin αVβ3 Integrins integrity internalization intracellular signaling life-threatening Loss mechanism motif multiple organ failure Pathways peptide phenotype phlogistic prevented Protein receptor redistribution RGD motif SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Spike protein Support the spike protein thrombotic Thrombotic complications Trigger Vascular vascular dysfunction vascular leakage [DOI] 10.3390/v14050891 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α v β 3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing AntibodiesSARS-CoV-2는 백신 유도 중화 항체가 있는 경우에도 α v β 3 인테그린 매개 세포내이입을 통해 인간 ACE2 음성 내피 세포를 감염시킵니다Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] absence ACE2 acute respiratory syndrome Angiogenesis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-spike antibodies antibody BNT162b2 BNT162b2 vaccine Cell clathrin conserved endocytosis Endothelial cell endothelial cell dysfunction endothelial cells enzyme Evidence expression functional gateway highlight Human human lung impair Infection inhibit SARS-CoV-2 integrin integrin-mediated Integrins Interaction Intervention Lineage maintain monoclonal antibody motif neutralize phenotype Presence Prevent productive viral replication promote Protein RBD Receptor binding domain respiratory responsible RGD motif SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants sequence Spike protein the SARS-CoV-2 the Spike the vaccine vaccination Viral viral envelope virus viruses αvβ3 integrin αvβ3 integrin. [DOI] 10.3390/v14040705 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular DynamicsMolecular Biosciences Published on 2022-02-142022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] accelerated association bind binding site Cluster conformational COVID-19 docking Dynamics Extracellular matrix free energy landscape hindrance host receptor Hypothesis integrin Integrins Interaction microenvironment molecular molecular dynamcis motif normal mode analysis Protein RBD residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 virus sequence spike the RBD Validity viruses [DOI] 10.3389/fmolb.2022.834857 PMC 바로가기 [Article Type] Molecular Biosciences
Multiple conformations of trimeric spikes visualized on a non-enveloped virusArticle Published on 2022-01-272022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, 치료제, [키워드] ATP C-terminal C-terminal domain cascade cellular membrane conformation conformations Cryoelectron microscopy cytoplasmic cytosolic domain host cells insertion Integrins membrane monomer Multiple N-terminal N-terminal domain Reoviridae RNA S-adenosylmethionine SAM spikes Structure Transcription Trigger triggered trimeric trimeric spike viral infection virus Virus structures [DOI] 10.1038/s41467-022-28114-0 PMC 바로가기 [Article Type] Article