Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteractionOriginal Article Published on 2024-07-142024-09-05 Journal: Clinical and molecular hepatology [Category] update2024, [키워드] HBV X protein Hepatitis B virus Hepatocyte nuclear factor Interferon-gamma MHC class II transactivator [DOI] 10.3350/cmh.2024.0060 PMC 바로가기 [Article Type] Original Article
Tripartite motif-containing protein 21 is involved in IFN-γ-induced suppression of hepatitis B virus by regulating hepatocyte nuclear factorsVirus-Cell Interactions Published on 2024-06-232024-09-05 Journal: Journal of virology [Category] update2024, [키워드] Hepatitis B virus Hepatocyte nuclear factor Interferon-gamma tripartite motif-containing protein 21 [DOI] 10.1128/jvi.00468-24 PMC 바로가기 [Article Type] Virus-Cell Interactions
Humoral and T cell responses to SARS-CoV-2 reveal insights into immunity during the early pandemic period in Pakistanarticle Published on 2023-12-012024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] IgG Interferon-gamma Receptor binding domain SARS-CoV-2 spike T cells [DOI] 10.1186/s12879-023-08829-1 PMC 바로가기 [Article Type] article
The white-footed deermouse, an infection-tolerant reservoir for several zoonotic agents, tempers interferon responses to endotoxin in comparison to the mouse and ratArticle Published on 2023-10-122024-09-05 Journal: bioRxiv [Category] update2024, [키워드] endogenous retroviruses Innate immunity interferon stimulated genes Interferon-gamma lipopolysaccharide pathogen recognition receptors type 1 interferons [DOI] 10.1101/2023.06.06.543964 PMC 바로가기 [Article Type] Article
Single-cell transcriptomics reveal hyperacute cytokine and immune checkpoint axis in patients with poor neurological outcomes after cardiac arrestArticle Published on 2023-05-272024-09-05 Journal: Med (New York, N.Y.) [Category] update2024, [키워드] Cardiac arrest cytokine immune checkpoint Inflammation Interferon-gamma monocyte natural killer cell nectin-2 Peripheral blood mononuclear cells Single-cell RNA-sequencing [DOI] 10.1016/j.medj.2023.05.003 PMC 바로가기 [Article Type] Article
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
The Pitfalls of Mining for QuantiFERON Gold in Severely Ill Patients With COVID-19Research article Published on 2022-10-012022-10-05 Journal: Mayo Clinic Proceedings: Innovations, Quality & Outcomes [Category] 치료기술, [키워드] Additive Analysis assessment C-reactive protein Cohort Coronavirus disease 2019 COVID-19 COVID-19 admission COVID-19 cohort COVID-19 infection COVID-19coronavirus disease 2019 CRPC-reactive protein demonstrated elevated evaluate Factor ferritin Follow-up GBMgradient boosting machine generate gold gradient boosting machine IGRAinterferon-gamma release assay Ill indeterminate Inflammatory marker Interferon-gamma interferon-gamma release assay interleukin-6 lactate dehydrogenase latent tuberculosis infection LDHlactate dehydrogenase leukocyte likelihood LTBIlatent tuberculosis infection lymphocyte management Mayo Clinic objective Patient patient population patients hospitalized patients without COVID-19 Platelet Pneumonia proportion QFT-PlusQuantiFERON-TB Gold Plus QuantiFERON QuantiFERON-TB Gold Plus Result risk screening test severe coronavirus disease severe COVID-19 Severe COVID-19 Infection Severe infection SHapley Additive exPlanations SHAPSHapley Additive exPlanations was performed [DOI] 10.1016/j.mayocpiqo.2022.06.004 [Article Type] Research article
Reactogenicity and immunogenicity of the second COVID-19 vaccination in patients with inborn errors of immunity or mannan-binding lectin deficiencyArticle Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] activity Adverse reaction analyzed Anti-SARS-CoV-2 S antibody Antibody Response Autoimmune Autoimmune diseases B-lymphocytes Cell Cohort cohort of patient comparable Course COVID-19 COVID-19 vaccination CVID deficiency detect Disease activity dysfunction effective Efficacy and safety Elecsy flow cytometry healthy control humoral humoral immune response Hypogammaglobulinemia IFN-gamma immune system Immunity immunization immunoassay immunodeficiency immunoglobulin replacement therapy in healthy individuals increased risk individual Interferon-gamma lymphocyte neutralization Patient Phenotyping pneumococcal provide reactogenicity receptor Safe SARS-COV-2 infection selective Seven subjects Support syndrome T cell response T-lymphocites the disease triggering underlying disease vaccination vaccine response Vero E6 Virus neutralization was performed well X-linked agammaglobulinemia XLA [DOI] 10.3389/fimmu.2022.974987 PMC 바로가기
Mendelian Susceptibility to Mycobacterial Disease: Retrospective Clinical and Genetic Study in MexicoOriginal Article Published on 2022-08-312024-09-04 Journal: Journal of Clinical Immunology [Category] 대상포진, [키워드] bcg vaccine Histoplasma IL-12Rβ1 Interferon-gamma interleukin-12 Mendelian susceptibility to mycobacterial disease [DOI] 10.1007/s10875-022-01357-8 PMC 바로가기 [Article Type] Original Article
Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article