B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates
Article
[키워드] addition
Alpha
animal model
association
B.1.351
Beta
caused
changes in
Characteristics
Chinese
circulating
Clinical signs
contribute
determine
distribution
drugs
early stage
Efficacy and safety
elevated
exhibited
IFN-γ
IL-17
Infection
Inflammatory
Inflammatory cytokine
interferon gamma
interleukin 17
investigated
less
Lower respiratory tract
lung tissue
mechanisms
mutated
Necrosis
NHP
NHPs
nonhuman primate
pathogenesis of SARS-CoV-2
pathogenic
pathogenicity
pathological changes
primate
provide
pulmonary inflammation
reduced
replicated
Research
rhesus macaque
SARS-CoV-2
SARS-CoV-2 strain
SARS-CoV-2 vaccine
SARS-CoV-2 variant
SARS-CoV-2 variants
severe lung injury
shedding
spike-specific T-cell response
strain
Strains
tissue
TNF-α
Transmission
upper respiratory tract
Vaccine
variant
variants of concern
viral distribution
viral shedding
virulence
virulent
VoC
VOCs
were infected
[DOI] 10.1128/spectrum.02263-22 PMC 바로가기
[DOI] 10.1128/spectrum.02263-22 PMC 바로가기