Emerging SARS-CoV-2 Genotypes Show Different Replication Patterns in Human Pulmonary and Intestinal Epithelial CellsArticle Published on 2021-12-232022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] B.1.1.7 B.1.351 Caco-2 cells calu-3 cells cell line cell lines characterisation Clinical practice coronavirus 2 COVID-19 culture supernatant Effectiveness Epidemiology evaluated Genome Genotype Human humans incidence infected cells intestinal epithelium isolate Lineage P.1 pandemic pattern pulmonary released replicate Replication replicative representing respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2 isolate show Spread transmission rate Vaccines variants variants of concern Vero E6 cell VERO E6 cells viral culture viral isolate Viral variants virus virus genotype Wuhan, China [DOI] 10.3390/v14010023 PMC 바로가기 [Article Type] Article
COVID-19 and gut immunomodulation코로나19와 장 면역 조절Review Published on 2021-12-142022-09-12 Journal: World journal of gastroenterology [Category] SARS, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition angiotensin-converting enzyme-2 antibodies association calprotectin changes in clinically Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cytokines dependent on direct infection disease disease severity Dysbiosis epithelial cell expresse Gastrointestinal gastrointestinal symptoms GI symptom GI symptoms GI Tract Gut gut microbiota Health heterogeneous hypoxia immune immune activation immune response Immunity immunoglobulin A impairment in vitro in vivo infect infected individual Infection Innate innate immune response intestinal epithelium observation organ organoids outcome Pathogenesis Patient positive Pre-existing diseases Probiotic Proinflammatory cytokine protease Protein reported required respiratory problems respiratory symptom Respiratory system rhesus SARS-CoV-2 serine 2 severe COVID-19 patient severe respiratory illness severity Stool supported Symptom symptomatic patient the disease therapeutic interventions Therapeutics transmembrane Viral RNA virus [DOI] 10.3748/wjg.v27.i46.7925 PMC 바로가기 [Article Type] Review
Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3Cellular and Infection Microbiology Published on 2021-11-012022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, [키워드] basolateral side cell tropism characterized children detectable difference disease enterocytes enteroids explain fetal gastrointestinal disease Genotype genotypes goblet cells highest Human human organoids humans infecting Infection intestinal epithelium isolate isolates Mild Nasopharyngeal samples Neonates Neurological symptom occur Paneth cell parechovirus PeV-A polarized epithelium Replication replication kinetics severe disease Stool strain Transwell [DOI] 10.3389/fcimb.2021.740662 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-ChipPharmacology Published on 2021-10-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 protein ACE2 receptor Anti-inflammatory Anti-viral approved cellular circulating coronavirus Coronavirus infection Coronaviruses COVID-19 COVID19 patients Culture cytokine production cytokine secretion deformation demonstrated drug Effect effective Endothelium enteric Gastrointestinal symptom Host Human human gastrointestinal tract infect cells Infection Inflammation Inflammatory Inflammatory response inhibited intestinal intestinal epithelial cell intestinal epithelium intestine intestine chip mononuclear cell nafamostat NL63 Organoid organs on chip pathology Patient PBMCs Peripheral blood Protease inhibitor recruitment reduction in Remdesevir Remdesivir SARS-CoV-2 SARS–CoV–2 These data Vascular endothelium viral entry Viral load Viral protein [DOI] 10.3389/fphar.2021.718484 PMC 바로가기 [Article Type] Pharmacology
Endocytosis and Transcytosis of SARS-CoV-2 Across the Intestinal Epithelium and Other Tissue BarriersImmunology Published on 2021-09-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome barrier Betacoronavirus cause characterized complexes coronavirus COVID-19 determine diagnostic dissemination endocytosis epithelium extracellular vesicle gastrointestinal tract Immunoglobulin in vitro intestinal intestinal epithelium intestine intestines mechanism MERS MERS-CoV Microfluidics Middle East Model Other overcome Placenta respiratory tract SARS-CoV SARS-CoV-2 syndrome Therapeutic strategies tissue transcytosis transfer Transmission viral particle virus [DOI] 10.3389/fimmu.2021.636966 PMC 바로가기 [Article Type] Immunology
Does methotrexate influence COVID-19 infection? Case series and mechanistic dataResearch Article Published on 2021-06-102022-10-28 Journal: Arthritis Research & Therapy [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome addition Affect Angiotensin-converting enzyme anti-SARS-CoV-2 IgG Case series case sery clinical assessment coronavirus coronavirus disease coronavirus disease 19 COVID-19 downregulating Follow-up healthy Infection initial intestinal epithelium Intestinal Organoids joint lung mechanistic data methotrexate mice mRNA Organoid protective effect protein expression receiving receptor remained Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Seven significantly susceptibility Symptoms the SARS-CoV-2 treated Treatment women [DOI] 10.1186/s13075-021-02464-4 PMC 바로가기 [Article Type] Research Article
Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned?Review Published on 2021-05-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Affect animal models biologic biopsy Cancer cells cell type Clinical data complex interaction Culture diarrhea enteric virus enteroid Gastrointestinal Gastrointestinal infection heterogenous host–virus interactions human infection human infections human intestinal organoid Interaction intestinal intestinal epithelium intestinal organoid intestinal stem cell knowledge lack multicellular New Organoid outcome pathogen produced Replication surgical specimen Transwell® villus viral pathogens virus [DOI] 10.3390/v13060999 PMC 바로가기 [Article Type] Review
The Mechanism of PEDV-Carrying CD3 + T Cells Migrate into the Intestinal Mucosa of Neonatal PigletsArticle Published on 2021-03-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition blood circulation CD3 CD3+ T cells CD4 CD8 Contact demonstrated epidemic diarrhea implication increase in Infection integrin intestinal intestinal epithelial cell intestinal epithelium intestine intranasal inoculation Migration multiplicity of infection nasal Neonatal neonatal piglets occur Pathogenesis PEDV Prevent survived T cell T cells therapy transferred Viral transmission virus [DOI] 10.3390/v13030469 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19SARS-CoV-2는 인간의 장에서 SARS-CoV보다 더 강력한 선천 면역 반응을 유도하고 덜 효율적으로 복제합니다.Article Published on 2021-01-012022-09-11 Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 치료기술, [키워드] Activation alternative route chemokines clinical observation clinical observations coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines dissemination Ex vivo gastrointestinal tract Gene Expression Gut Hong Kong Human human liver immune activation immunohistochemistry indicated infect infected with SARS-CoV-2 Infection Infectious virus Innate innate immune response interferon interferons intestinal epithelium intestinal tissue intestinal tissues intestine kidney tissues less manifestation Particles Patient patients plaque assays pro-inflammatory cytokine pro-inflammatory cytokines processed qRT-PCR replicate replicated Replication replication kinetics reported respiratory response robust SARS-CoV SARS-CoV-2 suggested surgical surgical operation surgical removal tissue tissues type I type I and type III interferons type III Type III interferons virus [DOI] 10.1016/j.jcmgh.2020.09.017 PMC 바로가기 [Article Type] Article
Type I interferon remodels lysosome function and modifies intestinal epithelial defense제1형 인터페론은 리소좀 기능을 재구성하고 장 상피 방어를 수정합니다.Article Published on 2020-11-242024-08-21 Journal: Microbial Cell Factories [Category] 살모넬라증, [키워드] intestinal epithelium lysosome mucosal defense Salmonella pathogenesis type I interferon