The Nucleocapsid Protein of SARS-CoV-2, Combined with ODN-39M, Is a Potential Component for an Intranasal Bivalent Vaccine with Broader FunctionalityArticle Published on 2024-03-082024-09-05 Journal: Viruses [Category] update2024, [키워드] bivalent vaccine broad vaccine Cell-mediated immunity intranasal neutralizing Abs ODN SARS-CoV-2 [DOI] 10.3390/v16030418 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Aerosol and Intranasal Exposure Models in FerretsArticle Published on 2023-11-292024-09-05 Journal: Viruses [Category] update2024, [키워드] aerosol animal model coronavirus COVID COVID-19 ferret intranasal Pathogenesis SARS-CoV-1 small particle [DOI] 10.3390/v15122341 PMC 바로가기 [Article Type] Article
Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamstersArticle Published on 2023-05-042024-09-05 Journal: eBioMedicine [Category] update2024, [키워드] convalescent plasma COVID-19 intranasal Prophylaxis SARS-CoV-2 [DOI] 10.1016/j.ebiom.2023.104597 PMC 바로가기 [Article Type] Article
Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3Original Article Published on 2023-05-032024-09-05 Journal: Molecular therapy : the journal of the American So [Category] update2024, [키워드] ataxin-3 ExoMotif Extracellular vesicles Gene therapy intranasal miRNA MJD SCA3 spinocerebellar ataxia type 3 [DOI] 10.1016/j.ymthe.2023.04.001 PMC 바로가기 [Article Type] Original Article
Prophylactic intranasal administration of lipid nanoparticle formulated siRNAs reduce SARS-CoV-2 and RSV lung infectionOriginal Article Published on 2023-03-082024-09-05 Journal: Journal of microbiology, immunology, and infection [Category] update2024, [키워드] COVID-19 intranasal LNP RSV SARS-CoV-2 siRNA [DOI] 10.1016/j.jmii.2023.02.010 PMC 바로가기 [Article Type] Original Article
Combining intramuscular and intranasal homologous prime-boost with a chimpanzee adenovirus-based COVID-19 vaccine elicits potent humoral and cellular immune responses in mice근육내 및 비강내 상동 프라임-부스트를 침팬지 아데노바이러스 기반 COVID-19 백신과 결합하면 마우스에서 강력한 체액성 및 세포성 면역 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adenovirus adenovirus-based Adenovirus-vectored vaccine Administered antibody titres approach BALB/c mice booster Cellular immune response ChAdTS-S coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines cytokine decrease Efficacy elicit elicited evaluated followed by group highest homologous humoral IFN-γ IFN-γ ELISPOT IgA IgG immune immune responses immunogenicity intracellular cytokine staining intramuscular intramuscular vaccination intranasal Meso Scale Discovery mice prime immunization priming protocol provide pseudovirus neutralizing antibody respiratory responsible SARS-CoV-2 serotype shown T-cell Response T-cell responses tested titre vaccination Vaccine variants vectored vaccine [DOI] 10.1080/22221751.2022.2097479 PMC 바로가기 [Article Type] Article
Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primatesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied Blood clinical investigation Coverage COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine release Diseases effective effort elicit Gam-COVID-Vac Health heterologous prime-boost IgA antibody IgG immune response Immunity immunization immunogenic immunogenicity Infection intranasal intranasal vaccine. intranasally K18-hACE2 transgenic mice less lung immunopathology mice mononuclear cell Mortality mucosal nasal mucosa neutralizing antibody non-human primate pandemic Peripheral blood Prevent proliferation protective immunity provided revaccination robust SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 serum Sputnik V systemic and local the vaccine Transmission vaccination Vaccination strategy Vaccine vaccine candidate variants of concern virus virus infection virus spread [DOI] 10.1080/22221751.2022.2119169 PMC 바로가기
A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS-CoV-2 variants비강 오미크론 백신 부스터는 새로운 SARS-CoV-2 변이체에 대한 강력한 중화 항체 반응을 이끌어냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absence adjuvants administration antibody Antibody Response boost booster Bronchoalveolar lavage caused clinical trial composed COVID-19 COVID-19 pandemic current deaths delta variant described disease severity domain dose effective Elevation elicit evidenced FIVE fused human infection human infections humans IgA Immunity immunogen intranasal leads mice MOST mucosal nasal nasal protein vaccine booster Neutralizing activity neutralizing antibody Neutralizing antibody response omicron Omicron variant Protein Receptor binding domain reduce respiratory SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV-2 spike SARS-CoV-2 transmission SARS-CoV-2 variant severity significantly single dose suggested the antibody response the disease vaccination Vaccine virus infection wild-type [DOI] 10.1080/22221751.2022.2053365 PMC 바로가기 [Article Type] Article
A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tractsArticle Published on 2022-11-302023-07-10 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), [키워드] Adenovirus Vector COVID-19 intranasal mucosal immunity Receptor binding domain SARS-CoV-2 Vaccine Viral vector [DOI] 10.1080/21645515.2022.2127292 PMC 바로가기
COVID-19 intranasal vaccines: current progress, advantages, prospects, and challengesCOVID-19 비강내 백신: 현재 진행 상황, 이점, 전망 및 과제Review Published on 2022-11-302022-09-12 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, [키워드] added Administered administration Antibody Response Cell-mediated immunity cellular immunity country COVID-19 COVID-19 pandemic COVID-19 vaccine disease highlight immune response Immunity induce injected injection intramuscular intranasal intranasal vaccine limit MOST mucosal mucosal immunity Multiple nasal pandemic Prevent Protective Replication robust SARS-CoV-2 SARS-CoV-2 vaccine secretory IgA shown stimulate Vaccine Vaccines virus infection virus transmission [DOI] 10.1080/21645515.2022.2045853 PMC 바로가기 [Article Type] Review