Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant TreatmentConcise Review Published on 2024-06-102024-09-05 Journal: Stem cells translational medicine [Category] update2024, [키워드] Amyotrophic lateral sclerosis epidermolysis bullosa immunotolerance Intravenous injection Myocardial infarction pluripotent sphingosine-1-phosphate stroke [DOI] 10.1093/stcltm/szae018 PMC 바로가기 [Article Type] Concise Review
Preclinical safety evaluation and tracing of human mesenchymal stromal cell spheroids following intravenous injection into cynomolgus monkeysResearch article Published on 2022-10-012022-10-05 Journal: Biomaterials [Category] Coronavirus, 비임상, [키워드] addressed administration ambient Blood blood vessel Cell death demonstrated dissociate Efficacy feasible Host hypoxic condition injection intravenous Intravenous injection less lung Mesenchymal stem cells mice Monkey MSC MSCs multiple sclerosis occurred Osteoarthritis physiological change Preclinical promote retention Safe Safety Single Cell small blood vessel small vessel Spheroid Stress stromal cell survival viability wound healing [DOI] 10.1016/j.biomaterials.2022.121759 [Article Type] Research article
Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus MonkeysArticle Published on 2022-09-012022-11-15 Journal: Pharmaceutical research [Category] COVID19(2023년), SARS, 진단, [키워드] aerosol alternative route animal model antibodies antibody antibody concentration approach caused Clinical studies Concentration demonstrated Diseases dose epithelial lining feasibility humanized monoclonal antibody inhalation intravenous Intravenous injection lung mice Mild Moderate COVID-19 Monkey nebulized Neutralizing neutralizing antibody pharmacokinetics PRNT reached remained respiratory tract safety profile SARS-CoV-2 SARS-COV-2 infection serum shown single dose Transport treating COVID-19 was used [DOI] 10.1007/s11095-022-03340-9 PMC 바로가기
A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal deliveryArticle Published on 2022-08-302022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Administered antibody approved B.1.1.529 B.1.617.2 broad-spectrum antivirals characterized circulating Clinical outcome Clinical use coronavirus Delta delta variant dosage drug effective Efficacy ENhance half-maximal inhibitory concentration hamster IC50 inhibit Intravenous injection knowledge Lungs mutants nasal nebulized neutralizing antibody omicron overcome Patient prevented Prophylactic provide Replication SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 variant therapeutic therapeutic efficacy therapy Treatment Vaccine variant virus-neutralizing VoC VOCs [DOI] 10.1038/s41392-022-01135-3 [Article Type] Article
Human placenta-derived mesenchymal stem cells transplantation in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical trial): safety profile assessmentClinical Trial Published on 2022-07-282022-10-05 Journal: Stem Cell Research & Therapy [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) administration adverse event Allogeneic Anti-inflammatory ARDS baseline cause caused Cell Cell therapy clinical Clinical sign clinical trial control group coronavirus COVID-19 COVID-19 pandemic death in COVID-19 demonstrated distress dose Efficacy enrolled evaluate evaluated feasible Health Hospitalization Human immunomodulatory injection intensive care intravenous Intravenous injection intravenously laboratory parameter Laboratory test mesenchymal stem cell morbidity and mortality not significantly different oxygen saturation participant Patient patients patients with ARDS patients with COVID-19 Phase I PL-MSC PL-MSCs Placenta mesenchymal stem cells (PL-MSC). protocol regenerative registry repeated Safe Safety assessment safety profile serum single dose standard treatment stem cell subject syndrome Treatment treatment group two group [DOI] 10.1186/s13287-022-02953-6 PMC 바로가기 [Article Type] Clinical Trial
Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection Research Published on 2022-07-222022-10-05 Journal: Nature Communications [Category] 변종, [키워드] added administer Antibiotics Bacteria Bacterial Bacterial infection bacteriophage bone Combination European expression infecting Infection Intravenous injection joint kill Local Lytic management P. aeruginosa Patient persistence phage Pseudomonas aeruginosa purified the patient therapeutic potential therapy treat treated Treatment unique variants virus [DOI] 10.1038/s41467-022-31837-9 [Article Type] Research
Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model코로나바이러스 질환 2019(COVID-19) mRNA 백신의 정맥 주사가 마우스 모델에서 급성 심근염을 유발할 수 있음Article Published on 2022-06-102022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome antigen expression Apoptosis Ballooning degeneration Blood Can cardiac Cardiac pathology change changes clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 mRNA vaccine different time point dose Evidence evidenced hepatocyte histological change histopathological IL-6 immunization immunostaining in vivo induce infiltrating immune cell inflammatory cell infiltration injection interferon intracardiac intramuscular intravenous Intravenous injection Messenger RNA mice Model mouse mouse model mRNA mRNA expression mRNA vaccine myocytes Myopericarditis Necrosis other organ provided reduce reported risk SARS-CoV-2 serum Serum level significantly significantly higher skeletal tissue Vaccine vaccine injection Vaccines vascular endothelial cells visceral weight loss Withdrawal [DOI] 10.1093/cid/ciab707 PMC 바로가기 [Article Type] Article
Advanced cell therapy with low tissue factor loaded product NestaCell® does not confer thrombogenic risk for critically ill COVID-19 heparin-treated patientsResearch article Published on 2022-05-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 임상, [키워드] administration Cell cells clinical study clinical trial COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Critically ill D-dimer demonstrated evaluated expression healthy donor HIDPSC immature in vitro Inflammatory response intravenous Intravenous injection less lung damage moderate MOST MSC Patient patients PCA plasma predict procoagulant procoagulant activity Procoagulant potential promote Prophylactic raising reduce responsible risk Safe Safety selected stromal cell TF/CD142 therapeutic therapeutic option Therapies therapy tissue Treatment unique [DOI] 10.1016/j.biopha.2022.112920 [Article Type] Research article
In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료Article Published on 2022-04-012022-09-11 Journal: Human gene therapy [Category] COVID19(2023년), SARS, 변종, [키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin [DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article
An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages조작된 나노 리포솜 인간 ACE2 미끼는 쥐와 인간 대식세포 모두에서 SARS-CoV-2 스파이크 단백질 유도 염증을 중화합니다Article Published on 2022-03-062022-09-11 Journal: Theranostics [Category] SARS, 유전자 메커니즘, [키워드] abrogate abrogated ACE2 activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding biotinylated canonical CCL-2 chemokines competitive inhibitor complex coronavirus CXCL-10 cytokine D614G deficiency DEGs demonstrated differentially expressed gene Effect enzyme expressing expression fusion generate glycoprotein hACE2 human ACE2 human host cells human macrophage human macrophages IKKβ IKKβ/NF-κB signaling IL-1β IL-6 Immune cell immune cells in vitro in vivo Infection Inflammation Inflammatory response Inflammatory responses inhibit SARS-CoV-2 inhibitor internalization Intravenous injection IκB lentivirus Liposome Liposome-Human ACE2 Macrophage macrophages mechanism mice molecular murine myeloid-specific IKKβ knockout. neutralize NF-κB NF-κB activation NF-κB signaling Protein rationale receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 spike glycoprotein severe acute respiratory syndrome Coronavirus Signaling spike spike glycoprotein Spike protein stimulated Therapeutic approach tissue inflammation TNFα Treatment was used wild type [DOI] 10.7150/thno.66831 PMC 바로가기 [Article Type] Article