Impact of COVID-19 on the neglected tropical diseases: a scoping reviewScoping Review Published on 2024-07-292024-09-05 Journal: Infectious Diseases of Poverty [Category] update2024, [키워드] COVID-19 Disability adjusted life years funding Investment Millennium Development Goals neglected tropical diseases research and development Sustainable Development Goals WHO [DOI] 10.1186/s40249-024-01223-2 PMC 바로가기 [Article Type] Scoping Review
Return on investment in science: twenty years of European Commission funded research in Alzheimer’s dementia, breast cancer and prostate cancerResearch Published on 2024-06-162024-09-05 Journal: Cost Effectiveness and Resource Allocation : C/E [Category] update2024, [키워드] Alzheimer’s disease Breast cancer European Commission FP5 FP6 FP7 funding Horizon 2020 indicators Innovation Investment Medical care outcomes Pharmaceuticals Policy Prostate cancer Public investment Research policy Return on investment (RoI) [DOI] 10.1186/s12962-024-00540-5 PMC 바로가기 [Article Type] Research
Global Veterinary Diagnostic Laboratory Equipment Management and Sustainability and Implications for Pandemic Preparedness Priorities 1article Published on 2023-04-012024-09-05 Journal: Emerging Infectious Diseases [Category] update2024, [키워드] Biosafety and biosecurity bioterrorism and preparedness budget and policy equipment maintenance and calibration global veterinary diagnostic laboratory equipment management and sustainability implications for pandemic preparedness Investment Laboratory management one health pandemic preparedness priorities Quality control surge capacity sustainability veterinary zoonoses [DOI] 10.3201/eid2904.220778 PMC 바로가기 [Article Type] article
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillanceArticle Published on 2022-10-072022-11-15 Journal: Science (New York, N.y.) [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome African Beta coronavirus country Delta diagnostics dispersal faster genomes genomic Health heterogeneous nature highlight increase in Infectious disease insight Investment limitation Local pandemic proportions SARS-CoV-2 SARS-CoV-2 epidemic sequence Sequencing Surveillance Threats turnaround time variant virus [DOI] 10.1126/science.abq5358 PMC 바로가기
Safety and immunogenicity of a SARS-CoV-2 recombinant protein nanoparticle vaccine (GBP510) adjuvanted with AS03: A randomised, placebo-controlled, observer-blinded phase 1/2 trialArticle Published on 2022-07-222022-10-06 Journal: EClinicalMedicine [Category] 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 approach AS03 cellular immunity CEPI clinical study conducted COVID-19 COVID-19 pandemic deviation displaying distribution dose eligible Emergency use enrolled evaluate evaluated flu vaccine foundation geometric mean concentration group groups healthy hospital Humoral immunity IgG antibody immunogenic immunogenicity injection site pain Intervention intramuscularly Investment Local Melinda Gate mitigate myalgia naïve nanoparticle nanoparticle vaccine neutralizing antibody observer-blinded outcome participant per-protocol phase Placebo placebo-controlled primary immunogenicity Protein protocol pseudovirus randomised RBD RBD IgG reached reactogenicity receive recipient Recombinant protein recombinant protein vaccine Registered reported Safety SARS-CoV-2 SARS-COV-2 infection second dose Stage study enrollment Support supported systemic AE systemic AEs T-cell immune responses the receptor-binding domain the vaccine titre Trial vaccination vaccination schedule Vaccine wild-type virus World Health Organization [DOI] 10.1016/j.eclinm.2022.101569 PMC 바로가기 [Article Type] Article
IgG N-glycome changes during the course of severe COVID-19: An observational study중증 코로나19 기간 동안 IgG N-글리코메 변화: 관찰 연구Meta-Analysis Published on 2022-07-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] 95% CI acute respiratory syndrome adjusted Affect age analysed Analysis bind Bisecting GlcNAc cause change changes in circulating Cohort cohorts competence complement system activation contrary coronavirus disease Coronavirus-2 Course COVID-19 COVID-19 case cytotoxicity determine education European Fc region foundation functions Fund Galactosylation glycan glycans glycosylation Health IgG IgG glycosylation immune cells immune response Immunoglobulin immunoglobulins immunosuppressive independent indicate Investment IQR lack magnitude males median age Meta-analysis Mild mild case Molecular epidemiology molecular mechanism Multiple Patient performed problem proinflammatory receptor regulate released Respiratory illness SARS-CoV-2 Science Severe case severe COVID-19 severe COVID-19 patient severity significantly statistically statistically significant supported the disease Youth [DOI] 10.1016/j.ebiom.2022.104101 PMC 바로가기 [Article Type] Meta-Analysis
Feasibility and lessons learned on remote trial implementation from TestBoston, a fully remote, longitudinal, large-scale COVID-19 surveillance study완전 원격, 종단, 대규모 COVID-19 감시 연구인 TestBoston에서 원격 시험 구현에 대한 타당성 및 교훈Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] Accessibility adaptive Adults age Antibody testing approach Asian assigned barrier Biomedical research Birth black Blood Boston clinical study clinical trial Cohort cohorts Community connection contribute COVID-19 COVID-19 infection COVID-19 pandemic Critical Data quality demographic groups engage Engagement enrolled Enrollment female greater imperative implementation IMPROVE individual initial Intensive Investment longitudinal Lower Massachusett medical system nasal swab offer Older paradigm shift participant Participation Patient Prevalence promote provided recruited recruitment reduce reducing remote reported required Research researcher retention risk factor Risk factors robust RT-PCR SARS-CoV-2 RT-PCR scientific rigor Sex study visit Support Surveillance Symptom Trial white [DOI] 10.1371/journal.pone.0269127 PMC 바로가기 [Article Type] Article
Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trialResearch article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, 임상, [키워드] 1:1 95% CI analyses Analysis BCG BCG vaccination Breastfeeding Cape Capital childhood computation computing Council COVID-19 COVID-19 testing died Donor double-blind Dream Efficacy enrolled Epigenetic evaluated Evidence female finding FIVE foundation functional funding had no hazard ratio healthcare healthcare worker hospitalisation hypersensitivity hypothesised Immunocompromised Infrastructure innate immune system introduced Investment IQR median age medical doctors morbidity morbidity and mortality non-specific Nurses occurred pandemic participant phase 3 trial placebo-controlled trial pregnant Prevent PROTECT provided randomised recruited reduction Registered resource respiratory tract infection Respiratory tract infections Safety SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity South Africa statistically significant Swedish Symptoms the placebo group trained immunity Treatment Tuberculosis Vaccine were assessed [DOI] 10.1016/j.eclinm.2022.101414 [Article Type] Research article
Accelerating research and development of new vaccines against tuberculosis: a global roadmap새로운 결핵 백신 연구 개발 가속화: 글로벌 로드맵Review Published on 2022-04-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] Fulltext, MERS, 진단, [키워드] accelerate accelerated antigens approaches clinical country COVID-19 vaccine dataset Determining effective Efficiency endpoints ENhance funding source immunological implementation introduced Investment Laboratory mechanism National provide public health Research specimens stimulate Trial Tuberculosis tuberculosis vaccine tuberculosis vaccines Vaccine Vaccine hesitancy vaccine production [DOI] 10.1016/S1473-3099(21)00810-0 PMC 바로가기 [Article Type] Review
Global COVID-19 Vaccine Inequity: Failures in the First Year of Distribution and Potential Solutions for the Future글로벌 코로나19 백신 불평등: 유통 첫 해의 실패와 미래를 위한 잠재적 솔루션Article Published on 2022-03-072022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Affect approach benefit country COVAX COVID-19 COVID-19 vaccine COVID-19 vaccines D develop distribution effective European country facilitate failure Future global pandemic Health Organization herd immunity Host Immunity include inequality intellectual property interface International international cooperation Investment knowledge majority manufacturing—R& not effective pandemic Pharmaceutical Company pharmaceutical industry Potential pricing resulting risk SARS-CoV-2 pandemic solution Support Technology transfer the SARS-CoV-2 transfer vaccination rate vaccination rates Vaccine Vaccines variant World Health Organization Year [DOI] 10.3389/fpubh.2022.821117 PMC 바로가기 [Article Type] Article