Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart TissuesArticle Published on 2022-10-012022-11-15 Journal: Advanced Science [Category] 신약개발, 치료제, [키워드] antiviral drugs approved drugs ATP2A2 cardiotoxic effect Cardiotoxicity cell death Clinical data clinical trial clinically concentrations contractile Coronavirus disease 2019 COVID-19 demonstrated drug drug candidate drug treatments dysregulation effective engineered heart tissue evaluate expression of gene fumarate handling HCN4 heart heart tissue High Throughput Screening Human human pluripotent stem cell-derived cardiomyocytes induced ion homeostasis limit MYH6 Patient powerful tool regulate Remdesivir Repurposed drug repurposed drugs for COVID-19. reveal Ritonavir RNA-seq analysis significantly Spread STEM therapy TNNT2 [DOI] 10.1002/advs.202203388 PMC 바로가기
Suppression and Activation of Intracellular Immune Response in Initial Severe Acute Respiratory Syndrome Coronavirus 2 InfectionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] activated acute respiratory syndrome Antiviral strategies candidate CD38 coronavirus coronavirus 2 correlation disease dysregulation early infection expression profile Factor highlighting Host Host immune response host restriction factors Immunity in viral in vitro experiments increase Infection inhibitory activity innate immune response Interaction interferon interferon response Intracellular Ion ion homeostasis log pathogen Ptx3 respiratory response SARS-CoV-2 suppressed suppression survival TCN1 therapeutic therapy transcriptional transcriptional dynamics Viral load virus Virus-host interactions [DOI] 10.3389/fmicb.2021.768740 PMC 바로가기 [Article Type] Microbiology
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of DiseaseReview Published on 2021-10-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Anti-viral antiviral therapy cellular membranes Community conserved contribute COVID-19 pandemic creating develop domain domains Effect Endoplasmic reticulum Express facilitate feature HCV hepatitis C highlight highlighting HIV Host host membrane HPV Human hydrophilic hydrophobic IAV immune evasion immune modulation immunomodulatory effect Infection Influenza Ion ion channels ion homeostasis knowledge mechanisms papillomavirus Polyomavirus Protein Proteins reading regulate replicative Research respiratory SARS-CoV Structure target Transport Treatment Vaccine Viral immune evasion viral infection virion assembly viroporins virus viruses [DOI] 10.3390/v13112165 PMC 바로가기 [Article Type] Review
Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and TherapiesSARS-COV-2에 의한 심근 손상 : 신흥 메커니즘 및 요법Review Published on 2021-09-212022-09-01 Journal: Viruses [Category] SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acting action potential acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis arrhythmia ATP attack autophagy cause Cell cells coronavirus creating damage decrease direct infection docking drug early stage early stages Effect effective Endothelial cell endothelial cells energy energy metabolism evade heart host cell Host immune response Imbalance immune cells immune response immunosuppressive immunosuppressive therapy induce infect Inflammation inhibit ion homeostasis lead leads metabolism myocardial damage myocarditis necroptosis organ Potential treatment priming programmed cell death promote protease Protease inhibitor protease inhibitors Proteases pyroptosis receptor Replication respiratory RNA-dependent RNA polymerase ROS production SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus ssRNA stages therapy treatment of viral infection turn Vesicle Viral viral clearance viral docking viral entry viral replication viroporin [DOI] 10.3390/v13091880 PMC 바로가기 [Article Type] Review
Similarities between the effect of SARS-CoV-2 and HCV on the cellular level, and the possible role of ion channels in COVID19 progression: a review of potential targets for diagnosis and treatmentReview Published on 2020-10-222022-10-31 Journal: Channels [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis can be used caused cellular Combination coronavirus COVID-19 pandemic COVID19 Diagnosis drug drug target effective Evidence exhibited expand HCV hepatitis C highlight identify immune responses in viral include Inflammation ion channels ion homeostasis knowledge Medicine offer patients peg-IFN Perspective prevention of COVID-19 pulmonary system reduction reveal Ritonavir SARS-CoV-2 similarity Symptom target the disease Treatment treatment approach treatments for COVID-19 Via Viral load viruses [DOI] 10.1080/19336950.2020.1837439 PMC 바로가기 [Article Type] Review
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and PathogenesisResearch Article Published on 2014-05-012022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accompanied Activation activity acute respiratory distress Affect airway Amino acid ARDS assays ATPase attenuate Cell channel compensatory mutation complexes Concentration correlated Critical cytokine cytosolic death Deletion demonstrated died disease Diseases displaying E gene E protein edema ENCODE envelope eventually death experiment fitness highly pathogenic IL-1β IL-6 in viral induce inducer Infection infections Inflammasome inflammasome activation Inflammatory cytokine Inflammatory response innate immune system Interaction involved Ion ion homeostasis less Level lost weight lung lung damage lung epithelia macromolecular maturation mechanism mice multifunctional protein mutant mutant viruses Mutation outcome Pathogenesis pathology produced progression promote Protein pulmonary damage reduced reducing required respiratory restored SARS-CoV SARS-CoV E SARS-CoV infection sequence severe hypoxemia significantly suppressed survived syndrome therapy this system TNF translated transmembrane protein Transport viral infection virulence virus virus growth virus pathogenesis virus production wild-type [DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article