Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic Lymphohistiocytosis심각한 VZV 감염 및 혈구탐식 림프조직구증을 앓고 있는 환자에서 E3 유비퀴틴 리가제 AMFR의 변이에 의한 STING 활성화 손상Article Published on 2024-01-262024-08-16 Journal: Journal of Clinical Immunology [Category] 대상포진, [키워드] AMFR HLH interferon ISG STING ubiquitin ligase VZV.
Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19Article Published on 2022-10-012022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Acute respiratory infection Comparative Coronavirus disease 2019 COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients death driving evaluated Genes Host transcriptional response host-pathogen interactions IFN-I IFN-I response Inflammation initial symptom interferon involved ISG ISGs lung mechanism Mild OAS Potential Profiling progression respiratory Respiratory failure RNA-Seq RNA-sequencing role SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe symptom stimulated symptomatic patient the disease tract type I interferon upper upper respiratory tract upregulated viral infection Viral load [DOI] 10.3390/v14102182 PMC 바로가기
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variantArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] Activation analyzed antiviral response arising Beta Calu-3 cell calu-3 cells cellular circumvent comparable replication correlated COVID-19 infection Delta Effect epithelial Evolution genomic host cell human lung Immunity induce innate immune innate immune activation Innate immunity interferon interferon response ISG ISGs mRNA expression Mutation mutations omicron pandemic produced Replication replication efficiency SARS-CoV-2 SARS-CoV-2 variant signaling pathways STAT2 stimulated Transmission Treatment vaccination Vaccine variant variants variants of concern variations Viral RNA virus virus replication while [DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 InfectionArticle Published on 2022-09-302022-11-16 Journal: Viruses [Category] SARS, 치료법, [키워드] A549 Analysis biopsy boost case-control study CBL confirmation COVID-19 COVID-19 patients displaying double-stranded expression gene expression profile highlighting host response Hub human cell line IFN-stimulated gene IFN-γ Immunotherapy in vitro infected with SARS-CoV-2 Infection ISG ISG15 ISGs ISGs. JAK2 liver lung lung cell MAP2K6 mice murine model MX1 MX2 OAS1 pathway patients positive correlation positive patients Responding RUNX3 SARS-CoV-2 SARS-COV-2 infection Stat1 target the patient tracheal treated upregulation Viral load was performed [DOI] 10.3390/v14102180 PMC 바로가기
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGUSP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다Article Published on 2022-08-062022-09-11 Journal: Cell Death & Disease [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication [DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responsesSARS-CoV-2에 대한 PBMC의 비생산적 노출은 세포 고유의 타고난 면역 반응을 유도합니다Article Published on 2022-08-012022-09-11 Journal: Molecular Systems Biology [Category] SARS, 치료기술, [키워드] absence ACE2 receptor analyzed baseline bystander cell bystander cells Cell COVID-19 Culture Cytokines detectable Ex vivo experiment exposure to expression expression profile expression profiles healthy donor healthy donors human PBMC immune responses in vivo induce infected cell Infection innate immune response Interaction interferon interferon-stimulated gene interferon-stimulated genes interferon-stimulated genes. Invasion ISG ISGs Mild monocyte Monocytes mounted Particle Patient PBMC PBMCs physical proinflammatory cytokines respiratory tract response RT-PCR SARS-CoV SARS-CoV-2 severe COVID-19 Single-cell RNA sequencing STAT stimulate susceptibility triggered virus particle virus particles [DOI] 10.15252/msb.202210961 PMC 바로가기 [Article Type] Article
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ωSARS-CoV-2에 대한 국소 인터페론 반응의 연령별 비교는 IFN-ε 및 -ω에 대한 역할을 제안합니다Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated Adults age anti-SARS-CoV-2 basal Basal transcription characterized children component components contribute develop diagnostic disease effective expression Genes highest Hospitalization IFN IFN response IFN-stimulated genes IFN-α IFN-ε IFN-λ1 IFN-ω IFNs individual infected individuals Infection Innate immunity interferon ISG ISG15 ISGs Mild Mild disease nasopharyngeal cell nasopharyngeal cells non-infected Occurrence Older overexpressed Protective quantified recent recognize relative expression response resulting risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individuals severe COVID-19 significantly higher starting swabs Symptom Transcription transcriptomic analysis type I type I and III IFNs type I interferon type III up-regulated [DOI] 10.3389/fimmu.2022.873232 PMC 바로가기 [Article Type] Article
Analysis of serum microRNAs and rs2910164 GC single-nucleotide polymorphism of miRNA-146a in COVID-19 patientsArticle Published on 2022-07-042023-07-08 Journal: Journal of immunoassay & immunochemistry [Category] COVID19(2023년), [키워드] COVID-19 IFI27 IFN response Inflammation ISG miRNA-122a miRNA-146a and miRNA-205 miRNA-146a rs2910164 SNP. SARS-CoV-2 [DOI] 10.1080/15321819.2022.2035394
Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severityCOVID-19 환자의 항-IFN-α/-ω 중화 항체는 IFN 반응의 하향조절 및 질병 중증도의 실험실 바이오마커와 상관관계가 있습니다Article Published on 2022-07-012022-09-11 Journal: European Journal of Immunology [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Antiviral association autoantibodies autoantibodies, SARS-CoV-2 binding binding antibodies binding antibody biochemical characterized COVID-19 COVID-19 patient cross-reactivity CRP D-dimer dimer disease severity downregulation fluctuation Gene Expression hematological parameters ICU IFN IFN response IFN-stimulated gene IFN-stimulated genes IFN-α interferon ISG ISGs laboratory biomarker laboratory biomarkers LDH male Neutralizing antibodies neutralizing antibody outcome Patient patients positive positive patient proportion quantified reduced respiratory Respiratory samples screened sera serum severe COVID-19 shown specificity subset tested transcript levels [DOI] 10.1002/eji.202249824 PMC 바로가기 [Article Type] Article
Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic OptionsSARS-CoV-2 회피의 특성화: 인터페론 경로 및 치료 옵션Review Published on 2022-06-082022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antagonism Antiviral antiviral therapy characterization characterized circumvent contribute Control Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 patients Critical critical state drug dysregulated Efficacy evade explain expression Factor helping host innate immunity IFN IFN response IFN signaling pathway IFN-III IFNs in some individual Infection inhibit innate immune innate immune response Innate immunity interferon interferon-stimulated gene ISG mechanism new SARS-CoV-2 option pathogenicity Pathways pro-inflammatory cytokine responsible robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the disease therapy treat Vaccines variant virus virus–host interactions [DOI] 10.3390/v14061247 PMC 바로가기 [Article Type] Review