Dynamics of viral shedding during ancestral or Omicron BA.1 SARS-CoV-2 infection and enhancement of pre-existing immunity during breakthrough infectionsArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Anti-RBD IgG antibody Breakthrough infection Cell cellular immunity cellular response circulating Delta Diagnosis Dynamics exhibited faster greater HCW HCWs healthcare worker humoral IFN-γ Immunity Infection infectiousness investigated isolates median neutralization capacity neutralizing antibody titre normalized omicron pandemic positive pre-existing immunity proportion reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 peptides SARS-CoV-2 variants symptom onset Vaccine vaccine-immunity variant viral clearance viral culture Viral load viral loads viral shedding [DOI] 10.1080/22221751.2022.2122578 PMC 바로가기
Increased Detection of Carbapenemase-Producing Enterobacterales Bacteria in Latin America and the Caribbean during the COVID-19 PandemicArticle Published on 2022-11-012022-11-16 Journal: Emerging Infectious Diseases [Category] 치료기술, [키워드] acute respiratory syndrome antibiotic use antimicrobial resistance Bacteria Bacterial infection Carbapenemase-producing Enterobacterales change characterized clinical setting coronavirus coronavirus disease Corso A country COVID-19 COVID-19 cases COVID-19 pandemic detection enteric infections et al. Increased detection of carbapenemase-producing Enterobacterales bacteria in Latin America and the Caribbean during the COVID-19 pandemic. Emerg Infect Dis. 2022 Nov [date cited]. https://doi.o food safety healthcare help increase Increased Infection prevention isolates Latin Latin America limitation Pasterán F Pillonetto M Prevalence Prevent reported Research respiratory infections resulting SARS SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Shal J Sosa A Suggested citation for this article: Romero Thomas G Surveillance the Caribbean Thoma Transmission viruses zoonoses [DOI] 10.3201/eid2811.220415 PMC 바로가기
Tools to Alleviate the Drug Resistance in Mycobacterium tuberculosisArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] 진단, [키워드] acid-fast bacillus Antibiotics Asymptomatic cause caused COVID-19 pandemic death detect diagnosed Diagnosis drug Drug discovery drug resistance drug-resistant estimates exhibiting Factor Frequency highlight Host intrinsically isolate isolates majority MDR molecular mechanism mutations Mycobacterium Mycobacterium tuberculosis Nucleic acid detection pathogen reduced reduction in resistance Treatment treatment regimen Tuberculosis WHO [DOI] 10.3390/molecules27206985 PMC 바로가기
Genomic diversity of SARS-CoV-2 in Pakistan during the fourth wave of pandemic전염병의 네 번째 물결 동안 파키스탄에서 SARS-CoV-2의 게놈 다양성Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha B.1.617.2 Beta variant characteristic circulating circulation conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D950N delta variant Delta variants exhibited followed by G142D genomic Genomic surveillance Germany globe highlight Illumina isolate isolates Karachi L452R lineages P681R Pakistan pandemic Patient Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus Singapore spike mutation T19R T478K United Kingdom V483A variant variants variants of concern whole-genome sequencing [DOI] 10.1002/jmv.27957 PMC 바로가기 [Article Type] Article
Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection KineticsArticle Published on 2022-09-122022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addition Analysis B.1 B.1.617.2 BAC BAC mutagenesis backbone Bacterial bronchial epithelial cells Carrying chromosome clinical comparable coronavirus Cytopathic effect disease Efficiency en passant mutagenesis epithelial cell line evaluate generate glycoprotein human lung Infection Infectious virus inhibitors isolate isolates Kinetics less Microscopy monoclonal antibody Mutagenesis Mutation neutralization nonstructural proteins nucleocapsid Numerous Post-vaccine Potential progression raise recombinant RNA role SARS-CoV-2 sera severity spike spike mutation spike mutations Spike protein Substitution suggested susceptible Syncytia Transmissibility Treatment variant viral fitness viral spike virus Virus life cycle VoC [DOI] 10.3390/v14092017 PMC 바로가기
Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In VivoArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 affected approach block comparable decoy receptors dimeric effective Efficiency escape mutations fused greater in vivo inhibit SARS-CoV-2 isolates monoclonal antibodies monomeric MoonTag multimerization Mutation mutations neutralization neutralized Neutralizing offer provide sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SunTag Therapeutic treatment Treatment trimeric unlikely variants of concern [DOI] 10.1002/advs.202201294 PMC 바로가기
Population structure of Mycobacterium tuberculosis from referral clinics in Western Siberia, Russia: Before and during the Covid-19 pandemicResearch article Published on 2022-09-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] 유전자 메커니즘, 치료기술, [키워드] analyzed association Beijing Beijing genotype changes in clinics collected COVID-19 decrease detection rate drug resistance Factor feature Genotype genotyping Health Hypothesis impacted incidence increase in isolate isolates Local MDR Mycobacterium tuberculosis pandemic Patient Population Prevalence proportion reduced resources Russia Siberia Tuberculosis while [DOI] 10.1016/j.meegid.2022.105343 [Article Type] Research article
Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor PaxlovidArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CLpro acute respiratory syndrome Analysis analyzed Antiviral antiviral drug Antiviral treatment antivirals baseline binding circulating cleavage clinical response conservation conserved Contact Coronaviral Coronaviridae family coronavirus COVID-19 COVID-19 pandemic Critical database determine drug target effort Emergency use authorization enzyme escape mutation EUA Evolution expected Genetic genomic GISAID globe health emergency implication inhibitor inhibitors initiative introduced isolate isolates M pro motifs MPro Mutation Nirmatrelvir pandemic progresse Paxlovid protease purifying selection raise reference sequence Region remained residue retrieved robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 viral selective sequence Sequencing starting point Surveillance the SARS-CoV-2 the spike protein Treatment unique variants variants of SARS-CoV-2 virus widespread Wuhan-Hu-1 [DOI] 10.1128/mbio.00869-22 PMC 바로가기
Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2 Research Published on 2022-08-182022-10-05 Journal: Nature Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Administered administration Antiviral applicability approach conserved Critical disease drugs genetic change Genome greater hamster highlight IAV identify Immunity implication in vitro in vivo influenza A virus isolates mice Mutation nucleic acid predicted Prophylactic Prophylaxis provided retained RNA RNA secondary structure RNA structure SARS-CoV-2 secondary structure survival the SARS-CoV-2 therapeutic targeting therapy Transmission Vaccine variant viral genome Viral RNA virus [DOI] 10.1038/s41591-022-01908-x [Article Type] Research
Early Isolates of SARS-CoV-2 Result in Different Pathogenesis in the Transduced Mouse Model of COVID-19SARS-CoV-2의 초기 분리물은 COVID-19의 형질도입된 마우스 모델에서 다른 병인을 초래합니다Article Published on 2022-08-132022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] Adenovirus alveolar inflammation BALB/c mice body weight Body weight loss Clinical sign Clinical signs COVID-19 dissemination expression followed by hACE2 hACE2 receptor Histopathology in vivo Infection isolate isolates kidney liver lung Lung histopathology Lungs mice Model mouse mouse model peaking post infection provide response Result resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 virus variant spleen subsequent recovery susceptible the SARS-CoV-2 virus transduced transduction undetectable Victoria viral variant Viral variants virulence virus weight loss [DOI] 10.3390/v14081769 PMC 바로가기 [Article Type] Article