Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors
강력한 SARS-CoV-2 주요 단백질분해효소 억제제로서의 주글론 및 그 유도체의 발견
Article
[키워드] acetyl
active site
Amino acid
amino acid residue
Analysis
antiviral activity
caused
Characteristics
characterized
Concentration
concentrations
contributed
coronavirus
COVID-19
demonstrated
derivative
Drug discovery
Efficacy
enzyme
evaluated
exhibited
Host
host cells
hydrogen
Hydrogen bond
hydrogen bonds
hydrolysis
in vitro
ingredient
inhibit
inhibitor
inhibitors
inhibitory
inhibitory activity
Juglone
M pro
M(pro) inhibitors
molecular docking studies
much higher
naphthoquinone
Naphthoquinones
non-toxic
outbreak
peptide
polyprotein
positive control
positive-sense single-stranded RNA
protease
proteinase
Replication
replication of SARS-CoV-2
Research
RNA coronavirus
SARS
SARS-CoV-2
significantly
suppress
tested
Transcription
Vero E6
Vero E6 cell
VERO E6 cells
Viral
virus
[DOI] 10.1016/j.ejmech.2021.113789 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.ejmech.2021.113789 PMC 바로가기 [Article Type] Article