junction – Communicable Diseases Research

The choroid plexus and its role in the pathogenesis of neurological infections

Article

Published on 2022-09-102022-11-15
Journal: Fluids and Barriers of the CNS
[Category] SARS, 치료기술, 치료제,

A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike

6-프롤린 안정화된 융합전 스파이크를 발현하는 매우 효과적인 약독화성 볼거리 바이러스 기반 SARS-CoV-2 백신 후보

Article

Published on 2022-08-162022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] antibody backbone candidate children COVID-19 vaccine Delta delta variant Delta variants effective expressed expressing expression Genome hamster human vaccine IFNAR1 immune responses Immunity immunization immunogenic Immunoglobulin immunoglobulin A include Infant Infants intranasal junction mice MMR MMR vaccine mucosal mump mumps virus neutralized Neutralizing antibodies neutralizing antibody prefusion proline prolines raised rapid increase Safe SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein T cell tetravalent Vaccine vaccine strain vaccine. variants virus
[DOI] 10.1073/pnas.2201616119 PMC 바로가기 [Article Type] Article

SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent origin

SARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology
[Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis analysis approaches assays Autoimmune disease Autoimmune diseases betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology Virology.
[DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article

CytoSorb Rescue for COVID-19 Patients With Vasoplegic Shock and Multiple Organ Failure: A Prospective, Open-Label, Randomized Controlled Pilot Study

Randomized Controlled Trial

Published on 2022-06-012022-10-04
Journal: Critical Care Medicine
[Category] 임상,

[키워드] 1:1 95% CI adjusted Adsorption adverse event age Antibiotics Berlin C-reactive protein clinical concentrations control group Controlled COVID-19 COVID-19 patient COVID-19 patients cytokine dose Effect Endpoint enrolled excluded Gender greater groups hazard ratio Hemodialysis ICU IMPROVE inflammatory markers interleukin-6 interquartile range IQR junction measurement median membrane Monmouth Mortality mortality rate Multiple one patient Patient pilot study primary endpoint Prospective Randomized receive reduction Registered registry rescue Resolution secondary Secondary endpoints Shock Standard of care Standard therapy study inclusion the primary endpoint treatment group university hospital variable Withdrawal
[DOI] 10.1097/CCM.0000000000005493 PMC 바로가기 [Article Type] Randomized Controlled Trial

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

고유한 서열 식별자를 식별하는 생물정보학 도구인 LeTRS를 사용하여 세포 배양, 동물 모델 및 임상 샘플에서 SARS-CoV-2 알려진 및 신규 서브게놈 mRNA 분석

Article

Published on 2022-05-262022-09-11
Journal: GigaScience
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animal model animal models bioinformatics Biology biology of SARS-CoV-2 can be used Cell Cell culture clinical sample clinical samples complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 data set diagnostics Direct RNA sequencing Each evaluate generate host response identify implication in some indicated Infection junction longitudinal samples mammalian mechanism medical countermeasure Medical countermeasures Middle East Middle East respiratory syndrome Coronavirus multiphasic Nanopore nasopharyngeal sample nucleic acid open reading frames other coronavirus other coronaviruses Patient plasticity provide Quantitative reflected Regulatory respiratory syndrome coronavirus RNA RNA modification SARS-CoV-2 selection pressure sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgmRNA sgmRNAs subgenomic mRNA subject target targets Transcription transcriptional regulatory sequences transcriptional regulatory sequences. Transmission model unique variant Viral RNA viral RNA synthesis virus was tested
[DOI] 10.1093/gigascience/giac045 PMC 바로가기 [Article Type] Article

Nanopore ReCappable sequencing maps SARS-CoV-2 5′ capping sites and provides new insights into the structure of sgRNAs

Nanopore ReCappable 시퀀싱은 SARS-CoV-2 5' 캡핑 사이트를 매핑하고 sgRNA의 구조에 대한 새로운 통찰력을 제공합니다

Article

Published on 2022-04-082022-09-11
Journal: Nucleic Acids Research
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles

SARS-CoV-2 스파이크 단백질의 "LLQY" 모티프는 S가 바이러스 입자에 통합되는 데 영향을 줍니다.

Article

Published on 2022-03-232022-09-11
Journal: Journal of Virology
[Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alter Amino acid amino acid residue amino acids antiviral drug antiviral drugs assembly biological significance Biosynthesis caused Cell culture cleavage cleavage site cleavage sites cleaved conformational conservation conserved Contact contribute coronavirus COVID-19 epidemic Critical demonstrated Effectiveness expressed glycoprotein hydrogen Hydrogen bond hydrogen bonds incorporation Infection intrachain junction key amino acid key amino acids less Lineage LLQY domain membrane fusion motif mutated Mutation Neutralizing antibodies Particle Prevent processing producer cell protease Protein protein synthesis protein synthesis and cleavage Pseudotyped virus pseudovirus pseudovirus pseudoviruses reduce residue S protein S1/S2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability subcellular localization synthesis the S protein the SARS-CoV-2 Transmission tyrosine Vaccines viral entry viral infection virus virus assembly. Virus-like particle virus-like particles
[DOI] 10.1128/jvi.01897-21 PMC 바로가기 [Article Type] Article

The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial Cells

Article

Published on 2022-02-112022-10-31
Journal: Cells
[Category] Coronavirus,

Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants

Tools and Resources

Published on 2021-09-282022-10-31
Journal: eLife
[Category] COVID-19, SARS,

[키워드] Affect Amplicon approach approach cDNA cDNA synthesis ClickSeq clinical sample Complete coronavirus genome Critical Defective RNAs driving event Evolution Final generate Genome genome coverage Genomics identify Illumina junction limitations nanopore sequencing Next-generation sequencing NGS nucleic acid pathogenicity PCR reaction platform primer primer pairs provide RNA RNA recombination robust SARS-CoV-2 SARS-CoV-2 isolate sensitivity sequence Sequencing sgmRNAs single-nucleotide SNV SNVs specificity Structural variant sub-genomic mRNA SVs Tiled-ClickSeq Transmission UMI Unique Molecular Identifier variant variants Variation virus virus genome viruses while
[DOI] 10.7554/eLife.68479 PMC 바로가기 [Article Type] Tools and Resources

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

SARS-CoV-2 주요 프로테아제에 의한 다양한 바이러스 기질의 인식

Article

Published on 2021-09-102022-09-11
Journal: ACS Infectious Diseases
[Category] Coronavirus, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution amino acid substitutions antiviral drug catalysis catalytic changes in cleavage cleavage site cleave conserved coronavirus coronavirus coronavirus disease Coronaviruses COVID-19 crystal structure crystal structures Efficiency ENhance homologous junction lifecycle M pro MPro NSP8 parameters peptide peptides polyprotein protease Proteases provide Recognition recognize Replication residue SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure structures substrate the SARS-CoV-2 unique viral nonstructural protein viral nonstructural proteins viral replication Virology Virology. Visualization
[DOI] 10.1021/acsinfecdis.1c00237 PMC 바로가기 [Article Type] Article