Effectiveness of Kabasura Kudineer tablets in the management of asymptomatic and mild cases of COVID-19: A pilot double-blinded, randomized controlled trialOriginal Research Article Published on 2023-08-012024-09-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] update2024, [키워드] clinical trial complementary medicine COVID-19 Kabasura kudineer [DOI] 10.1016/j.jaim.2023.100777 PMC 바로가기 [Article Type] Original Research Article
In silico anti-viral assessment of phytoconstituents in a traditional (Siddha Medicine) polyherbal formulation – Targeting Mpro and pan-coronavirus post-fusion Spike proteinArticle Published on 2023-07-132024-09-05 Journal: Journal of Traditional and Complementary Medicine [Category] update2024, [키워드] COVID-19 Dynamics iddha medicine Kabasura kudineer molecular docking MPro Post fusion spike protein SARS-CoV-2 [DOI] 10.1016/j.jtcme.2023.07.004 PMC 바로가기 [Article Type] Article
Safety and efficacy of Siddha management as adjuvant care for COVID-19 patients admitted in a tertiary care hospital – An open-label, proof-of-concept Randomized Controlled TrialOriginal Research Article Published on 2023-04-112024-09-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] update2024, [키워드] complementary medicine herbal medicine Kabasura kudineer Maldevi chenduram severe covid-19 Siddha RCT Traditional medicine [DOI] 10.1016/j.jaim.2023.100706 PMC 바로가기 [Article Type] Original Research Article
Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach전통 인도 의학에 의한 COVID-19에 대한 면역 체계의 활성화 메커니즘 이해: 네트워크 약리학 접근Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 신약개발, 유전자 메커니즘, [키워드] ACE activating acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alarm Algorithm alternative medicine approach approved betulinic acid biological process cathepsin cathepsin B cathepsin L cellular clinical trials Compound compounds coronavirus 2 COVID-19 COVID-19 infection determine disease DPP4 drug drug design drug target effective EGFR Emergency use enrichment analyses enrichment analysis Evolution functions gene-gene interaction globe HDAC2 identify IL6 immune system Interaction involved JACOM Kabasura kudineer mechanism medication Medicine molecular docking studies Molecular docking study molecular functions Mutation network network pharmacology Nilavembu kudineer pandemic pathway Pathways performed phenyl plant plants Potential treatment predict raising respiratory RIPK1 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects target targets the SARS-CoV-2 Traditional Traditional Indian Medicine. Transmission transmissions treat treating COVID-19 understanding Vaccine VEGFA Virtual screening was used [DOI] 10.1016/bs.apcsb.2021.11.007 PMC 바로가기 [Article Type] Article
Structure-based docking, pharmacokinetic evaluation, and molecular dynamics-guided evaluation of traditional formulation against SARS-CoV-2 spike protein receptor bind domain and ACE2 receptor complexOriginal Paper Published on 2021-10-182022-10-31 Journal: Chemicke Zvesti [Category] COVID-19, [키워드] ACE2 ACE2 receptor Analysis angiotensin-converting enzyme 2 antiviral property binding caffeic acid Cell classical clinical trial complex Computational docking study docking docking score domain Favipiravir FIVE Glide in silico in vivo experiment Interaction Kabasura kudineer Ligand MD simulation molecular molecular dynamics nontoxic outbreak pandemic PDB pharmacokinetic preventive measure Protein RBD receptor residue ribavirin SARS-CoV-2 SARS-CoV-2 spike protein selected Selection Shwas kuthar rasa Siddha suggested supplementary material Talisadi churna the SARS-CoV-2 therapeutic viral entry was performed was used [DOI] 10.1007/s11696-021-01917-z PMC 바로가기 [Article Type] Original Paper
Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized controlled trial, Tamil Nadu, IndiaRandomized Controlled Trial Published on 2021-09-152022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 95% CI adverse effect adverse event age Asymptomatic Asymptomatic COVID-19 Asymptomatic COVID-19 cases AYUSH Biochemical parameters changes in Chennai clinical clinical examination clinical presentation clinical symptom co-morbidities conducted control group coronavirus disease COVID COVID-19 COVID-19 cases Ct value declined drug Efficacy effort exploratory groups IFNγ IL-10 IL-2 IL-6 Immunity in both groups India individual interferon gamma Kabasura kudineer marker Necrosis no significant difference observé Occurrence Polyherbal decoction polymerase chain Primary outcome progressed progression Randomized Randomized controlled trial randomized, controlled trial recruited reduced reducing reduction in registry Result SARS-CoV-2 viral load Secondary outcomes Siddha Siddha Medicine significantly single-center Standard of care statistical analysis symptomatic t -test the disease the SARS-CoV-2 the study group threshold TNF α Traditional medicine Trial Vaccine Viral load Vitamin C was used [DOI] 10.1186/s13063-021-05583-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CL proMolecular Biosciences Published on 2020-12-232022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 3CL pro 6LU7 acting anti-viral effects antiviral drugs antiviral therapy applied approach approved binding energy bioinformatics Compound cough COVID-19 Critical develop Drug discovery drugs Effect effective Fever Gamma Geraniol global pandemic identify iGemdock inhibit inhibitors of SARS-CoV-2 Kabasura kudineer molecular docking plant protease SARS-CoV-2 selected Shortness of breath sore throat Symptoms tested the disease these compound World Health Organization [DOI] 10.3389/fmolb.2020.613401 PMC 바로가기 [Article Type] Molecular Biosciences