killer-cell immunoglobulin-like receptor

[키워드] 95% CI advanced age adverse outcome adverse outcomes age Autoimmune diseases circulating class Clinical course Combination combinations Combined Comparisons correlated Course COVID-19 COVID-19 progression Critical Defense disease disease course disease severity Diversity expressed Factor focus form frequencies Frequency functional gene frequencies Genetic geographical areas group Haplotype haplotypes HLA HLA C1 HLA Class I ligands HLA ligand hospitalized patient host defense human host immune response immune response mechanisms Immune-mediated immunogenetic characteristics individual Infection innate and adaptative immune response mechanisms Intervention investigated killer-cell immuno-globulin-like receptor killer-cell immuno-globulin-like receptors killer-cell immunoglobulin-like receptor KIR KIR A/A KIR gene KIR genes KIR receptor KIR receptors KIR2DS2 KIRs less Ligand lymphocyte Lymphocytes Male sex marker Mortality Multivariate analysis natural NK cell NK cell immune-mediated response Patient patients patients with SARS-CoV-2 Population protective effect reduce reduced regulated Result Sardinian SARS-COV-2 infection severe disease severe disease course severe symptom severe symptoms severity Sex statistically significant symptomatic the disease these cell These cells Viral viral infections
[DOI] 10.1371/journal.pone.0255608 PMC 바로가기 [Article Type] Research Article