Developing kinase inhibitors for malaria: an opportunity or liability?article Published on 2023-09-302024-09-01 Journal: Trends in Parasitology [Category] 말라리아, [키워드] Drug repurposing kinases malaria Polypharmacology resistance target-based drug discovery [Article Type] article
Author Correction: Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2article Published on 2023-08-102024-09-05 Journal: Communications Biology [Category] update2024, [키워드] Herpes virus kinases [DOI] 10.1038/s42003-023-05207-0 PMC 바로가기 [Article Type] article
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
Honghua extract mediated potent inhibition of COVID-19 host cell pathways홍화 추출물 매개 코로나19 숙주 세포 경로의 강력한 억제Article Published on 2022-08-222022-09-11 Journal: Scientific Reports [Category] 치료기술, 치료법, 치료제, [키워드] alkaline phosphatase Analysis Antiviral effect applied Chinese Compound COVID-19 crocin enzyme exhibited Extract high affinity host cell human ACE2 receptor Inflammation investigated kinases mechanism Medicine network pharmacology pathway Pathway analysis phosphatase potential mechanism potential mechanisms Signaling signaling pathway Simulation Traditional Traditional Chinese medicine virus [DOI] 10.1038/s41598-022-15338-9 PMC 바로가기 [Article Type] Article
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies마비 관련 키나아제는 SARS-CoV-2 감염에 필요하며 항바이러스 전략의 세포 표적입니다Article Published on 2022-08-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] AAK1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral strategy approach approaches approved caused cellular combination treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated drugs epithelial cells Erlotinib experiment expression functional GAK Genetic global health Health Host-targeted antivirals human lung human lung epithelial cells implication in vitro inhibited kinase kinase inhibitors kinases late stage life cycle multiple RNA viruses Numb Numb-associated kinases other coronaviruses pandemic pharmacological principle probe reported required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro SARS-CoV-2 life cycle SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus siRNA small molecule STK16 sunitinib suppressed synergistic synergistic effect target the SARS-CoV-2 threat treat viral entry wild type [DOI] 10.1016/j.antiviral.2022.105367 PMC 바로가기 [Article Type] Article
When cyclin-dependent kinases meet viral infections, including SARS-CoV-2사이클린 의존성 키나제가 SARS-CoV-2를 포함한 바이러스 감염을 만날 때Review Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral CDKs Cell cell division Critical Defense demonstrated DNA DNA viruses drug target function highlight Host in viral Infection kinase kinases molecular protein kinase protein kinases recent Regulation RNA RNA viruses SARS-CoV-2 Therapeutic strategies therapeutic strategy transcriptional regulation viral infection viral infections [DOI] 10.1002/jmv.27719 PMC 바로가기 [Article Type] Review
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] addition Anti-inflammatory can be used Cell cells Chinese composed Compound COVID-19 Cyclooxygenase cytokine Cytokines determine diploid endotoxin ERK expression Extracellular family Gram-negative bacteria Helicase IL-1β Immune cell immune cells immune system Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibit interleukin interleukin-1β involved IκBα JNK kinases lipopolysaccharide LPS LPS-induced inflammation MAPK mechanism mitogen NF-kB NF-кB nitric oxide nitric oxide synthase no effect nuclear outer membrane p65 pathway Pathways pro-inflammatory mediators proinflammatory mediators protein kinase required SARS Coronavirus SCU scutellarein scutellarein (SCU). secretion shown stimulate stimulated TNF-α Topic treat Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was reduced western blot [DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
Phosphoproteomics Unravel HBV Triggered Rewiring of Host Phosphosignaling EventsArticle Published on 2022-05-042023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] Hepatitis B virus Kinase inhibitor kinases kinome Phosphoproteomics phosphosignaling [DOI] 10.3390/ijms23095127 PMC 바로가기 [Article Type] Article
Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patientsCOVID-19 환자에서 IFNAR1 및 TYK2 전사체의 발현 분석Article Published on 2022-05-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] Analysis Biomarker blood sample Cell competent Control controls COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients disease severity down-regulated down-regulation expression female ICU admission IFN response IFNAR1 immune responses Incapacity Jak kinases male member molecular mechanism not different p value Patient Protein Regulation required SARS-CoV-2 Signaling significantly transcript TYK2 TYK2. Type I IFN tyrosine venous venous blood [DOI] 10.1016/j.cyto.2022.155849 PMC 바로가기 [Article Type] Article