Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication RatesArticle Published on 2022-09-122022-11-15 Journal: Journal of Chemical Information and Modeling [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral assist cellular compensated computation COVID-19 diffusion duplication Efficiency Enzymes highlight histidine Inclusion infecting Infection lack leading less Lower lysine mechanism modeling nucleotide Pandemics performed polymerase polymerases Rate reactive reactivity Replication replication of SARS-CoV-2 RNA RNA genome RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 genome Site subsequent the SARS-CoV-2 viral genome Viral RNA virus [DOI] 10.1021/acs.jcim.2c00802 PMC 바로가기
Evaluating the Performance of Centers for Disease Control and Prevention COVID-19 Community Levels as Leading Indicators of COVID-19 MortalityArticle Published on 2022-09-012022-11-16 Journal: Annals of internal medicine [Category] Fulltext, MERS, 변종, [키워드] Analysis CDC center Community complicate Control Council COVID-19 death diagnostic elevated evaluate Evaluating Evolution exceeded Hospital admission Hospital admissions hospitalizations Immunity IMPROVE Indicator interquartile range IQR leading Level lower mortality median medium Metrics Mortality mortality rate mortality risk National Negative predictive value outcome performance Positive predictive value Predictive predictor prevention public health Ratio reported risk sensitivity specificity state Support Surveillance threshold time Viral variants [DOI] 10.7326/M22-0803 PMC 바로가기
Structural Equation Modeling (SEM): Gaming Disorder Leading Untreated Attention-Deficit/Hyperactivity Disorder to Disruptive Mood DysregulationSEM(Structural Equation Modeling): 치료되지 않은 주의력 결핍/과잉행동 장애를 파괴적인 기분 조절 장애로 이끄는 게임 장애Article Published on 2022-05-292022-09-12 Journal: International Journal of Environmental Research an [Category] MERS, 진단, [키워드] ADHD applied children COVID-19 develop diagnosed disorder DMDD dysfunction dysregulation emotional equation evaluate hidden IGD Internet Intervention leading mediator. mental health modeling mood pathway progression questionnaire risk SEM significantly more Swanson Symptom Symptoms Version was used Youth youths [DOI] 10.3390/ijerph19116648 PMC 바로가기 [Article Type] Article
At Least Three Doses of Leading Vaccines Essential for Neutralisation of SARS-CoV-2 Omicron VariantSARS-CoV-2 오미크론 변이체 중화에 필수적인 주요 백신 최소 3회 투여Article Published on 2022-05-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] AlphaFold AstraZeneca biomolecular modelling coronavirus disease Coronavirus disease-19 COVID-19 Delta different time point different time points Donor donors dose equity Essential followed by Gender generate leading limit of detection Moderna neutralisation Neutralising Antibodies neutralising antibody neutralising antibody titres neutralizing antibody titre Older omicron Omicron variants Pfizer plasma samples reduction in SARS-CoV-2 second dose significantly Spike protein timepoints titre titres Vaccine Vaccines variants variants of concern virus neutralization assay virus neutralization assays were assessed [DOI] 10.3389/fimmu.2022.883612 PMC 바로가기 [Article Type] Article
Compassion Fatigue and Secondary Trauma During the COVID-19 Pandemic: Leading the Movement to Refashion Compassion (FR201)Conference abstract Published on 2022-05-012022-10-05 Journal: Journal of pain and symptom management [Category] 유전자 메커니즘, [키워드] addition anticipated Burnout Care changed clinician Clinicians Compassion complex component Consequences COVID-19 COVID-19 pandemic decrease emotional Emotional exhaustion event Factor fatigue group discussion identify IMPROVE indicate Injury leading movement palliative Palliative care pandemic participant Patient potential risk produced Quality of life Research risk risk factor Satisfaction secondary self-care social isolation Stress Substance use Support terminology trauma while [DOI] 10.1016/j.jpainsymman.2022.02.238 [Article Type] Conference abstract
Computational Modeling of T Cell Hypersensitivity during Coronavirus Infections Leading to Autoimmunity and Lethality자가 면역 및 치사율로 이어지는 코로나바이러스 감염 중 T 세포 과민증의 전산 모델링Article Published on 2022-03-222022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 변종, [키워드] Analysis angiotensin antiviral drug Autoimmune response autoimmune responses Autoimmunity binding CD147 COVID-19 COVID-19 treatment Critical Delta determinant determinants develop docking domain hACE2 human Angiotensin-converting enzyme Hyperactivation implication in silico indicated individuals infected with SARS-CoV-2 Interaction investigated involved isoform leading lethality memory T cell memory T cells MERS MERS-CoV modeling molecular molecular docking molecular dynamics not affect omicron Omicron variants outcome outcomes Patient performed polar interaction polar interactions Protein binding provide receptor receptors residue resulting SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe COVID-19 shown Spike protein suggested T cell T cells the SARS-CoV-2 transmembrane glycoprotein Treatment variants of SARS-CoV-2 viral spike protein [DOI] 10.1155/2022/9444502 PMC 바로가기 [Article Type] Article
Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study비만 및 심혈관 합병증을 유발하는 비스페놀 A(BPA): 생체 내 연구 모음Review Published on 2022-03-092022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] affecting animal model article articles Biomarkers Bisphenol A cardiovascular cardiovascular complication cardiovascular complications change changes in Chemical Clinical signs COVID-19 current data extraction database databases described Direct dosage Effect Effects Endocrine Endocrine disruptor endocrine disruptors Evidence evidence of fat Genes Gut gut microbiota humans identify in vivo indicate information instances involved LDL leading library Lipid Lipodystrophy lipolysis mechanism Nature neuroimmune signals notable obese obesity operator overweight OVID Pathways Perspective phenocopy Regulation Safe scientific evidence selected Signaling signaling pathways subject Support toto transgenerational effects. Trial trials was done weight were used [DOI] 10.3390/ijms23062969 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
First Case of a COVID-19 Patient Infected by Delta AY.4 with a Rare Deletion Leading to a N Gene Target Failure by a Specific Real Time PCR Assay: Novel Omicron VOC Might Be Doing Similar Scenario?Case Report Published on 2022-01-252022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Analysis Antigen Atypical circulating COVID-19 Deletion Delta delta variant Diagnosis diagnostic assay diagnostic tests Europe failure Genes GISAID sequence globe highlight Hospitalized Infection Interpretation Italian leading Lineage male MiSeq molecular N gene N gene target failure Nasopharyngeal swab negativity NGS novel nucleocapsid deletion nucleotides omicron Omicron variant Patient PCR performed positive result Prevalence responsible SARS-CoV-2 SARS-CoV-2 genome sequencing SARS-CoV-2 sequencing sequence Specific target time variant VoC [DOI] 10.3390/microorganisms10020268 PMC 바로가기 [Article Type] Case Report
Cytokine Storm in COVID-19: Immunopathogenesis and TherapyCOVID-19의 사이토카인 폭풍: 면역 병인 및 치료Review Published on 2022-01-182022-09-12 Journal: Medicina [Category] SARS, 진단, [키워드] administration affected Allogeneic allogeneic hematopoietic stem cell transplantation Anakinra antibody autoinflammatory disease CAR Care clinically Coagulopathy conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill critically ill patients cytokine cytokine inhibitors Cytokine storm Cytokines death deregulated disease disease severity effective effort excessive production of cytokines glucocorticoid Glucocorticoids GM-CSF Graft Graft-versus-host disease Hematopoietic stem cell hemophagocytic lymphohistiocytosis Hope hyperinflammatory state IFN-γ IL-1 IL-10 IL-2 IL-6 immune cells immune system IP-10 jak inhibitors leading MCP-1 Methylene blue mitigate multi-organ failure Novel coronavirus novel coronavirus disease overcome pandemic Pathogenesis Patient Plasmapheresis pro-inflammatory cytokines reducing mortality secondary hemophagocytic lymphohistiocytosis secondary to Sepsis severe cases stem cell Stem cell transplantation storm syndrome T-cell tested the cytokine storm the disease therapeutic strategy therapy TNF-α to define Tocilizumab [DOI] 10.3390/medicina58020144 PMC 바로가기 [Article Type] Review