Risk of reinfection and disease after SARS-CoV-2 primary infection: Meta-analysisArticle Published on 2022-10-012022-11-16 Journal: European Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 변종, [키워드] baseline cohort study COVID-19 criteria Critical disease evaluate evaluated Frequency Gender health care need individuals Infection lethal disease Meta-analysis natural immunity no substantial difference not affected omicron Omicron variant performed pooled rate Primary infection proportion reached Reinfection remained Repository risk SARS-CoV-2 searched severity stratified subject subjects subset vaccination vaccine dose viral strain were recorded [DOI] 10.1111/eci.13845 PMC 바로가기
A universal SARS-CoV DNA vaccine inducing highly cross-reactive neutralizing antibodies and T cellsArticle Published on 2022-09-022022-11-15 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 변종, 비임상, 진단, [키워드] antibody Beta contagious cross-reactive Delta DNA vaccine domain evade functional Human human ACE2 receptor Immunity induce lethal disease lethal infection membrane mice neutralized neutralizing antibody New observation omicron pandemic priming PROTECT Protective SARS-CoV SARS-CoV vaccine SARS-CoV-2 Spike protein T cell T cells the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants virus WHO [DOI] 10.15252/emmm.202215821 PMC 바로가기
Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19숙주 키티나제 3-유사-1은 COVID-19의 SARS-CoV-2 바이러스 변이체에 대한 보편적인 치료 표적입니다Article Published on 2022-06-232022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] accumulate ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha anti-CHI3L1 antibody Antibody neutralization Beta breakthrough infections caused Cell CHI3L1 chitinase Concentration coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 defined Delta delta variant demonstrated determine effective inhibitor epithelial epithelial cell Express FRG genetic variability host tissue induce Infection Infectious disease inhibit inhibitor Intervention kasugamycin Laboratory lethal disease Microbiology morbidity and mortality neutralization omicron priming protease pseudovirus pseudoviruses S protein SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease spike stimulate strain susceptibility the disease therapeutic target Therapeutics Transmissibility variant variants variants of concern viral variant viruses VoC Waves worldwide pandemic [DOI] 10.7554/eLife.78273 PMC 바로가기 [Article Type] Article
Ex-vivo mucolytic and anti-inflammatory activity of BromAc in tracheal aspirates from COVID-19COVID-19의 기관 흡인물에서 BromAc의 생체 외 점액 용해 및 항염 활성Article Published on 2022-04-012022-09-12 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), MERS, SARS, 신약개발, 임상, 진단, 치료제, [키워드] Acetylcysteine anti-inflammatory activity anti-inflammatory effect BromAc caused chemokine collected Combination Concentration COVID-19 COVID-19 patient COVID-19 patients Critically ill CXCL8 Cytokine analysis Cytokine storm dose drug evaluated Ex vivo G-CSF IL-10 IL-13 IL-5 IL-6 IL-9 IP-10 lethal disease MCP-1 mechanical ventilation MIP-1b mucolysis mucolytic Mucolytic therapy NAC pandemic pharmacological treatment public health threat reducing reduction reduction in regulatory cytokine Respiratory disease robust SARS-CoV-2 sputum therapeutic options tracheal tracheal aspirate treat was performed [DOI] 10.1016/j.biopha.2022.112753 PMC 바로가기 [Article Type] Article
Detection and classification of COVID-19 disease from X-ray images using convolutional neural networks and histogram of oriented gradientsResearch article Published on 2022-04-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 진단, 치료기술, [키워드] accompanied Accuracy addition approach caused chest X-ray Chest X-ray image CNN collected country COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 pandemic COVID-19 test deaths deep learning detection diagnose Diagnosis diagnosis of COVID-19 diagnostic died equipment evaluated experiment feature help HOG hospitals humans increase in infected with COVID-19 Kera lack lethal disease machine learning Measures novel coronavirus disease patients Radiologists spread to SVM TensorFlow Treatment unique university was performed was used X-ray YOLOv3 [DOI] 10.1016/j.bspc.2022.103530 [Article Type] Research article
Human genetics of SARS-CoV-2 infection and critical COVID-19Review Published on 2022-02-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료제, [키워드] antiviral immune response antiviral response autoantibody Autoimmune clinical implication Complication content Course COVID-19 Critical Diagnosis disease disease course disease manifestation Genetic genetic loci genetics Genome-wide association studies Human humans hypothese IFN immune Immunity IMPROVE Inborn error of immunity individual Infection Inflammatory Innate immunity interferon knowledge lethal disease men MIS-C Neutralizing objective outcome outlined Pandemics pathophysiological mechanism pathophysiology pathway Patient patients with SARS-CoV-2 Pneumonia Prophylaxis proportion provide provided reduce response retrospective SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 Signaling Source susceptibility susceptible individual the SARS-CoV-2 Treatment Type I IFN virus whole-exome sequencing [DOI] 10.1016/j.cmi.2022.02.022 [Article Type] Review
Novel coronavirus pathogen in humans and animals: an overview on its social impact, economic impact, and potential treatments인간과 동물의 신종 코로나바이러스 병원체: 사회적 영향, 경제적 영향 및 잠재적 치료법에 대한 개요Review Published on 2021-12-012022-09-11 Journal: Environmental science and pollution research inter [Category] SARS, 유전자 메커니즘, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals caused coronavirus coronavirus disease CoV COVID-19 COVID-19 mortality deaths Economy emerging pathogens exceeded Health Health Organization Human human pathogen humans Infection international public health lethal disease lockdowns measure mechanism MERS Middle East Middle East respiratory syndrome movement National novel Novel coronavirus outbreak pandemic pandemic of COVID-19 pathogen pathogenicity Pathogens Potential Potential treatment SARS-CoV SARS-CoV-2 SARS-CoV-2 virus Sequencing severe acute respiratory syndrome Coronavirus Social impact. spread to Symptoms syndrome therapy for COVID-19 Transmission Travel viral disease WHO World Health Organization worldwide pandemic [DOI] 10.1007/s11356-021-16809-8 PMC 바로가기 [Article Type] Review
Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in miceResearch Article Published on 2021-12-012022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] Antibody Response binding conditions conformational COVID-19 pandemic description domain dose effective glycoprotein hACE2 human Angiotensin-converting enzyme immunization immunized immunogenic induce inhibited intramuscular vaccination lethal disease Liposome live SARS-CoV-2 low-dose mice neutralized PROTECT protective immunity pseudotyped QS-21 RBD RBD binding SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 vaccines spike transgenic mice Vaccine vaccine dose viral challenge virus [DOI] 10.1126/sciadv.abj1476 PMC 바로가기 [Article Type] Research Article
Blood Transcriptomes of Anti-SARS-CoV-2 Antibody-Positive Healthy Individuals Who Experienced Asymptomatic Versus Clinical InfectionImmunology Published on 2021-10-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ALOX15 analysed Anti-SARS-CoV2 antibody Antibody Response asympomatic Asymptomatic Asymptomatic disease asymptomatic infection baseline baseline expression Bioinformatics analysis CACNA2D2 CLEC12A CLEC1B clinical clinical variability Course decreased expression develop differentially expressed gene ENC1 energy metabolism FOLR3 GCAT gene signature GZMH healthy individuals Hypothesis IFI44L IFIT3 immune immune response implication increased expression individual Infection innate immune response Innate immunity interferons involved lethal disease mRNA translation nine oxidative stress response PCR performed PI3 predicts protein-coding gene Proteins regulated RNA sequencing RNAseq robust RSAD2 SARS-CoV-2 SARS-COV-2 infection significantly transcriptional vaccination Whole-blood [DOI] 10.3389/fimmu.2021.746203 PMC 바로가기 [Article Type] Immunology
Emerging and Established Histological Techniques for the Analysis of Thrombosis in COVID-19 LungsCardiovascular Medicine Published on 2021-09-212022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory syndrome caused coronavirus Coronavirus disease 2019 COVID - 19 COVID-19 COVID-19 treatments described dimensions gold standard histological histology increased risk lethal disease lung MINI Pathogenesis progression pulmonary review SARS-CoV-2 severe COVID-19 technique thrombosis with COVID-19 [DOI] 10.3389/fcvm.2021.745906 PMC 바로가기 [Article Type] Cardiovascular Medicine