Molnupiravir’s mechanism of action drives “error catastrophe” in SARS-CoV-2: A therapeutic strategy that leads to lethal mutagenesis of the virusEditorial Published on 2023-06-282024-09-05 Journal: Molecular Therapy. Nucleic Acids [Category] update2024, [키워드] error catastrophe lethal mutagenesis molnupiravir SARS-CoV-2 [DOI] 10.1016/j.omtn.2023.06.006 PMC 바로가기 [Article Type] Editorial
Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of RibavirinAntiviral Agents Published on 2023-01-052024-09-05 Journal: Med Instrum [Category] update2024, [키워드] COVID-19 lethal mutagenesis ribavirin SARS-CoV-2 Viral quasispecies [DOI] 10.1128/aac.01315-22 PMC 바로가기 [Article Type] Antiviral Agents
Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic ActivityReview Published on 2022-04-182023-07-01 Journal: Viruses [Category] COVID19(2023년), SARS, [키워드] error catastrophe Favipiravir HIV lethal mutagenesis molnupiravir nucleoside analogs ribavirin RNA polymerase SARS-CoV-2 [DOI] 10.3390/v14040841 PMC 바로가기 [Article Type] Review
[Plitidepsin, an inhibitor of the cell elongation factor eEF1a, and molnupiravir an analogue of the ribonucleoside cytidine, two new chemical compounds with intense activity against SARS-CoV-2][세포신장인자 eEF1a 억제제 플리티뎁신과 리보뉴클레오시드 시티딘 유사체 몰누피라비르, SARS-CoV-2에 대한 강력한 활성을 가진 두 가지 새로운 화합물]Review Published on 2021-10-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] SARS, 치료제, [키워드] Administered administration analogues animals Cell cellular Compound Culture cytidine decrease determine elongation factor English human cell human clinical trials inhibiting inhibitor Interaction intravenously knowledge lethal mutagenesis molnupiravir molnupiravir (MK-4482/EIDD-2801) Mutagenesis oral administration oropharynx phase Plitidepsin potency Prevent Prophylaxis Protein pulmonary viral Remdesivir replicative Ribonucleoside SARS-CoV-2 SARS-CoV-2 sntiviral Spanish therapeutic Transmission virus [DOI] 10.37201/req/042.2021 PMC 바로가기 [Article Type] Review
Decoding molnupiravir-induced mutagenesis in SARS-CoV-2SARS-CoV-2에서 몰누피라비르 유발 돌연변이 유발 해독Editors' Pick Highlight Published on 2021-06-092022-09-10 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] antiviral drug biochemical clinical trial clinical trials COVID-19 COVID-19 therapy COVID-19, coronavirus infectious disease 2019 demonstrated involved lethal mutagenesis mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular mechanism molecular mechanisms molnupiravir Mutagenesis NHC NHC, β-D-N4-hydroxycytidine nucleoside prodrug RdRp, RNA-dependent RNA polymerase RNA polymerase RNA synthesis rNTP, ribonucleoside triphosphate SARS-CoV-2 SARS-CoV, severe acute respiratory syndrome coronavirus Template therapy Viral Viral RNA Virological evidence [DOI] 10.1016/j.jbc.2021.100867 PMC 바로가기 [Article Type] Editors' Pick Highlight
Broad-Spectrum Antiviral Strategies and Nucleoside AnaloguesReview Published on 2021-04-132022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] absence analogue antiviral drugs antiviral molecule antiviral nucleoside analogue antiviral strategy broad-spectrum antiviral broad-spectrum antivirals Chain terminator drug drugs targeting Ebola Efficacy Epidemic Health include Influenza lethal mutagenesis limitations mechanism MERS-CoV Middle East new strain nucleoside nucleoside analogue Nucleoside analogues outbreak pandemic public health emergency Replication respiratory SARS-CoV-2 Strategy threat Vaccine development virus virus infection viruses Zika [DOI] 10.3390/v13040667 PMC 바로가기 [Article Type] Review
Imposed mutational meltdown as an antiviral strategyReview Published on 2020-10-272023-06-15 Journal: Evolution; International Journal of Organic Evolution [Category] MERS, SARS, [키워드] antivirals lethal mutagenesis Mutational meltdown Population genetics SARS‐CoV‐2 [DOI] 10.1111/evo.14107 PMC 바로가기 [Article Type] Review
Viral quasispecies바이러스 유사종Topic Page Published on 2019-10-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive adopted Antiviral classical competition complex consensus sequence consensus sequences Crossing deep sequencing defined distribution distributions Frequency Genetic variation Genome high mutation rate high mutation rates in viral information Interpretation leads lethal mutagenesis life limit methodology Mutagenesis mutant mutant clouds mutant spectra mutant swarm mutant swarms mutants Mutation mutation rate Mutation rates pathogen Pathogens populations present day provided Quasispecies quasispecy relative frequency Replication RNA virus RNA viruses Standard clonal analyses Standard clonal analysis theory transition unit variant Viral Viral quasispecies viral replication Virology viruses wild type [DOI] 10.1371/journal.pgen.1008271 PMC 바로가기 [Article Type] Topic Page
Establishment of a Cell Culture Model of Persistent Flaviviral Infection: Usutu Virus Shows Sustained Replication during Passages and Resistance to Extinction by Antiviral NucleosidesArticle Published on 2019-06-172023-08-29 Journal: Viruses [Category] E형 간염, [키워드] antiviral therapies Chronic viral infection defective viral genomes emerging arboviruses lethal mutagenesis [DOI] 10.3390/v11060560 PMC 바로가기 [Article Type] Article
New strategies against drug resistance to herpes simplex virusReview Published on 2016-03-252024-09-02 Journal: International Journal of Oral Science [Category] 대상포진, [키워드] drug resistance herpes simplex virus Janus-type nucleoside analogues lethal mutagenesis new strategies [DOI] 10.1038/ijos.2016.3 PMC 바로가기 [Article Type] Review