Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers장기간 코로나바이러스를 가진 개인의 스페인 코호트에서 지속되는 과민성 세포독성 면역 반응: 진단 바이오마커의 식별Article Published on 2022-03-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Accuracy Algorithm analyzed Antiviral Autoimmune disease Blood blood type caused CD3 CD4 CD56 CD57 CD8 CD8+ CD8+ T cells cells characterized chest pain clinical feature Clinical management Cohort cytotoxic cytotoxic activity cytotoxic immune response Definition demographic factor Demographic factors detect diagnostic biomarker Diagnostic biomarkers expression female gender forest functional hypotheses identification immune immune exhaustion. immune parameter immunological parameter immunological parameters IMPROVE individual Infection Inflammatory response lethargy Long long-COVID long-lasting Lymphocytes marker mechanism memory cell Memory cells NK cell NK cells organ participant patients PD-1 persistence persistent phenotype pleuritic Population Post-infection predicted Random forest Random Forest algorithm recovered completely response SARS-CoV-2 significantly increased Signs and symptoms Spanish supported sustained Symptom symptoms of COVID-19 syndrome T cells T lymphocytes Temra cells tissue Treg Tregs [DOI] 10.3389/fimmu.2022.848886 PMC 바로가기 [Article Type] Article
Clinical profile, risk factors and outcomes of ric COVID-19: a retrospective cohort multicentre study in Saudi ArabiaObservational Study Published on 2022-03-112022-10-04 Journal: BMJ Open [Category] 임상, [키워드] 1.26 95% CI adjusted Admission analysed Bacterial infection Chest children clinical clinical complications Clinical presentations Comorbidity Complication complications COVID-19 Critical Critical care D-dimer Dyspnoea elevated ferritin Health higher odd hospital Hospital stay ICU ICU admission increased risk increased the risk Intensive intensive care Laboratory lethargy mean participant age medical record multicentre outcome outcomes Paediatric intensive & paediatric patient paediatrics Patient patients PCR positive recruited retrospective retrospective cohort risk factor Risk factors Saudi Arabia supportive care tested the mean White blood cell [DOI] 10.1136/bmjopen-2021-053722 PMC 바로가기 [Article Type] Observational Study
Analysis of Neurological Adverse Events Reported in VigiBase From COVID-19 VaccinesNeurology Published on 2022-01-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] administration Adverse adverse effect adverse events Adverse events following immunization AEs Ageusia Analysis Anosmia approval association AZD1222 BNT162b2 BNT162b2 vaccine carried clinical trials conducted COVID-19 COVID-19 vaccine COVID-19 vaccines database Descriptive statistics Dizziness eight event facial paralysis Frequency headache lethargy Long-term follow-up mRNA-1273 mRNA-1273 vaccine neurological neurological adverse event Neurological disorder Neurological disorders neurological system pandemic post-COVID-19 vaccination reported sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Seizure sleep quality study period System the vaccine the WHO vaccination Vaccine Vero with COVID-19 [DOI] 10.7759/cureus.21376 PMC 바로가기 [Article Type] Neurology
New-Onset Primary Adrenal Insufficiency and Autoimmune Hypothyroidism in a Pediatric Patient Presenting with MIS-CArticle Published on 2022-01-012022-11-15 Journal: Hormone research in pædiatrics [Category] 진단, [키워드] ACTH Adolescent Adrenal Adrenal insufficiency Antibody titer autoantibodies Autoimmune autoimmune conditions basal baseline bradycardia causal link children Clinical course COVID-19 creatinine criteria cytokine diarrhea EKG fatigue Fever healthy hemoglobin hemorrhage Hydrocortisone Hypothyroidism Hypothyroidism. immune Inflammatory Inflammatory marker inflammatory state initial initiated insufficiency intensive care intravenous knowledge lethargy MIS-C myocarditis oligomenorrhea PCR pediatric persistent positive positive COVID-19 reported required SARS-CoV-2 IgG SARS-COV-2 infection Shock sodium stimulated subsequent Support syndrome Thyroid Thyroiditis triggering TSH undetectable unique vomiting [DOI] 10.1159/000525227 PMC 바로가기
SARS-CoV-2 Post Vaccinated Adverse Effects and Efficacy in the Egyptian PopulationArticle Published on 2021-12-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] administration Adverse adverse effects Anti-spike antibody Antibody titers average collected COVID-19 detect determine dose doses Effect fatigue headache IgG Immunity IMPROVE injection Laboratory tests lethargy Mild MOST much higher no symptom overcome participant Participants Population positive Post-vaccine questionnaire required SARS-CoV-2 SARS-COV-2 infection second dose Sinopharm Sinopharm vaccine Spike protein Symptom vaccination Vaccine [DOI] 10.3390/vaccines10010018 PMC 바로가기 [Article Type] Article
Within- and across-day patterns of interplay between depressive symptoms and related psychopathological processes: a dynamic network approach during the COVID-19 pandemicResearch Article Published on 2021-11-302022-10-28 Journal: BMC Medicine [Category] Coronavirus, MERS, SARS, [키워드] addition amplification approach association component concerning conducted COVID-19 pandemic Daily Depression depressive depressive symptom Depressive symptoms detrimental Dynamic network analysis Effect exhibited General adult population greater helplessness identify impacted implication indication individual Intensive Interaction investigated involved lethargy longitudinal study mechanism mechanisms network analysis Nomothetic time series analysis observation pandemic predicted proximal Psychopathological mechanisms Regulation repeated measure required response Result supplementary material susceptible symptoms of depression these symptom [DOI] 10.1186/s12916-021-02179-y PMC 바로가기 [Article Type] Research Article
Hamsters as a Model of Severe Acute Respiratory Syndrome Coronavirus-2중증 급성 호흡기 증후군 코로나바이러스-2의 모델로서의 햄스터Review Published on 2021-10-012022-09-11 Journal: Comparative medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect age alveolar animal model animal models clinical disease Clinical outcome clinical outcomes Clinical sign Clinical signs contributed convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical death develop edema Effect Efficacy granulocyte hamster hamsters Health hemorrhage highlight human infection human infections humans Implications infected with SARS-CoV-2 Infection infiltration Injury inoculation interstitial lead lethargy lose weight Mesocricetus Model Mortality pandemic Pathogenesis Pneumonia preclinical studies preclinical study progression of disease pulmonary lesion pulmonary lesions Pulmonary pathology renal required respiratory Respiratory disease Respiratory system ruffled fur SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe infection severe infections Sex shown Spread Therapeutics Treatment vaccination virus variant virus variants weight while [DOI] 10.30802/AALAS-CM-21-000036 PMC 바로가기 [Article Type] Review
Case Report: Dilated Cardiomyopathy in a Newborn, a Potential Association With SARS-COV-2Pediatrics Published on 2021-08-062022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] acute respiratory syndrome Angiotensin-converting enzyme Cardiomyopathy cause Clinical course clinical note coronavirus COVID-19 COVID-19 disease COVID-19 infection decompensated heart failure demonstrated develop diarrhea dilated cardiomyopathy discharged Echocardiogram Evidence follow-up period heart failure Heart transplantation inhibitors intubation investigation lethargy Nasopharyngeal swab Newborn Patient pediatric positive Potential progressed required Respiratory failure SARS-CoV-2 tachypnea tested ventricular dysfunction [DOI] 10.3389/fped.2021.674300 PMC 바로가기 [Article Type] Pediatrics
Clinical and Histopathologic Features of a Feline SARS-CoV-2 Infection Model Are Analogous to Acute COVID-19 in HumansArticle Published on 2021-08-052022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] ACE2 expression acute COVID-19 animal model ARDS clinical clinical disease controls correlation COVID-19 COVID-19 disease Diffuse alveolar damage distal domestic cats dry cough Dyspnea evaluate feline Fever genetic modification Hospitalized Host Human humans hyaline membrane formation immune response include Infection intratracheal lesion lesions lethargy Lungs Model nasal turbinates other organs pathology produced pulmonary pulmonary lesions quantified Respiratory disease Result SARS-CoV-2 SARS-COV-2 infection translational urgency viral infection were infected [DOI] 10.3390/v13081550 PMC 바로가기 [Article Type] Article
Unusual Presentation of Acute Perimyocarditis Following SARS-COV-2 mRNA-1237 Moderna VaccinationCardiology Published on 2021-07-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Acute kidney injury adverse event Anti-inflammatory Biomarker BNP cardiac cardiovascular event Case report CDC Course COVID-19 COVID-19 vaccination death deteriorate diagnosed with COVID-19 diarrhea discharged Disseminated intravascular coagulation ECG elevated finding headache hemodynamic instability highlight hospital Hospital stay Infection intravenous fluids investigated lethargy low blood pressure mass vaccination medication Moderna Moderna vaccine mrna-1237 myocarditis non-specific NSAIDS outcome pandemic PCR peptide performed Perimyocarditis Pfizer-BioNTech polymerase chain presentation SARS-CoV-2 second dose Spread Symptom the patient treated vaccination Vaccine vomiting [DOI] 10.7759/cureus.16590 PMC 바로가기 [Article Type] Cardiology