Ecotoxicological Characterization of Lithium as a “Timebomb” in Aquatic Systems: Tadpoles of the South American Toad Rhinella arenarum (Hensel, 1867) as Model OrganismsArticle Published on 2024-02-252024-09-05 Journal: Toxics [Category] update2024, [키워드] aquatic contamination Environmental risk Li tadpoles [DOI] 10.3390/toxics12030176 PMC 바로가기 [Article Type] Article
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry비만의 유전자 × 신체 활동 상호 작용: 유럽 조상 111,421명의 통합 분석Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity Adult Adults age aggregate effect allele analyses Analysis ancestry attenuate Author BMI calculated Characteristics Cohort cohorts Combined cumulative cumulative effect detected diminishe environmental exposure European Europeans Evidence evidence of examined FTO gene × environment interactions genetic risk genetic risk score Genetic variant Genome-wide association studies genotyped GRS heterogeneity Inclusion indicated individual inefficient inhibit Interaction interaction effect interactions knowledge Li linear loci locus logistic regression model meta-analyses Meta-analysis multicenter Multiplicative interaction Multiplicative interactions North North America nucleotide Numerous obesity Participants physical activity provide Questionnaires replicated Replication reported Sample size SEC16B Secondary analyses Sex single nucleotide polymorphisms SNP SNP × physical activity interactions statistically significant Support tested treated variant [DOI] 10.1371/journal.pgen.1003607 PMC 바로가기 [Article Type] Research Article
The SARS Coronavirus S Glycoprotein Receptor Binding Domain: Fine Mapping and Functional CharacterizationResearch Published on 2005-08-252022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] ACE2 Alanine amino acid residue appear binding binding energy Cell characterization characterized cloned contribute decrease determined eight expressed expression functional Glutamine glycoprotein glycosylation glycosylation site identify immune responses include indicate initiated kDa lack Li mapping mechanism molecular weight Mutagenesis mutated Mutation not affect R426 RBD receptor receptor ACE2 reduced required residue residues S RBD SARS Coronavirus significantly Simultaneous submitted suggested the RBD the receptor-binding domain These data [DOI] 10.1186/1743-422X-2-73 PMC 바로가기 [Article Type] Research