Potential Targets and Mechanisms of Bitter Almond-Licorice for COVID-19 Treatment Based on Network Pharmacology and Molecular Dockingarticle Published on 2023-12-132024-09-05 Journal: Current Pharmaceutical Design [Category] update2024, [키워드] Bitter almond COVID-19 licorice molecular docking network pharmacology Traditional Chinese medicine [DOI] 10.2174/0113816128265009231102063840 PMC 바로가기 [Article Type] article
Bioactive prenylated phenolic compounds from the aerial parts of Glycyrrhiza uralensisArticle Published on 2022-09-012023-07-09 Journal: Phytochemistry [Category] COVID19(2023년), [키워드] 3CL(pro) cytotoxicity Glycyrrhiza uralensis Leguminosae licorice PL(pro) SARS-CoV-2 virus [DOI] 10.1016/j.phytochem.2022.113284
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsuleLianhuaqingwen Capsule을 투여 한 후 글리 시르 시리 사르 우랄 렌 시스 뿌리 (Gancao)에서 유래 한 슈도 알로 스테 겐 화합물의 약동학 적 식별Clinical Trial Published on 2021-12-012022-08-31 Journal: Acta pharmacologica Sinica [Category] 바이오마커, 임상, 치료제, [키워드] 11β-hydroxysteroid dehydrogenase 2 24-hydroxyglycyrrhetic acid access acid activated bile characterized China circulating metabolite colonic colonic microbiota Combination component components Compound condition COVID-19 COVID-19 treatment dehydrogenase exposure to facilitate feces Gancao-induced pseudoaldosteronism glycyrrhetic acid Glycyrrhiza uralensis glycyrrhizin hepatic human kidney Human plasma implication in vitro induce inhibit inhibiting intestinal intestinal absorption LianhuaQingwen licorice licorice-induced pseudoaldosteronism. liquiritigenin liver membrane permeability metabolism metabolite microbiota pharmacokinetic plasma protein Plasma Protein Binding Protein binding receiving renal Safe Saponin significant level systemic Therapeutic benefit Transport Treatment treatment for COVID-19 tubular reabsorption Volunteer volunteers [DOI] 10.1038/s41401-021-00651-2 PMC 바로가기 [Article Type] Clinical Trial
Licorice ( Glycyrrhiza glabra ) Extracts-Suitable Pharmacological Interventions for COVID-19? A ReviewReview Published on 2021-11-262022-10-28 Journal: Plants [Category] COVID-19, [키워드] acute respiratory distress addition Anti-inflammatory anti-inflammatory drug anti-inflammatory properties Antiviral antiviral drug ARDS clinical trial component contribute coronavirus COVID-19 COVID-19 patients COVID-19 symptoms database develop Glycyrrhetinic acid glycyrrhiza glycyrrhizic acid in vitro in vivo inhibit Intervention licorice mechanism medication medicinal plants Mortality Previous studies Replication review SARS-CoV-2 pandemic shown suggested syndrome the SARS-CoV-2 the vaccine Treatment vaccination was selected Web of Science [DOI] 10.3390/plants10122600 PMC 바로가기 [Article Type] Review
Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19Pharmacology Published on 2021-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE analyzed Anti-inflammation Antiviral binding Cell Characteristics Chinese clinical symptom clinical trials component Coronavirus disease 2019 COVID-19 dry cough Effects expected Fever glycyrrhizin immunomodulatory effects IMPROVE Inflammatory factor inflammatory mediator inhibit interfere licorice mechanism of action mechanisms Mild moderate molecular mechanism outbreak pandemic pathogenesis of COVID-19 pathway Patient pharmacological Pharmacological Effects Potential Prevent respiratory diseases Shortness of breath significant difference significantly stimulated suggested Symptoms target therapeutic Topic Traditional traditional uses treat Treatment type I interferon Vaccine virus spike protein [DOI] 10.3389/fphar.2021.719758 PMC 바로가기 [Article Type] Pharmacology
Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infectionArticle Published on 2021-11-262023-06-16 Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 Glycyrrhetinic acid licorice Licorice-saponin A3 SARS-CoV-2 [DOI] 10.1016/j.jare.2021.11.012 PMC 바로가기
Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2Article Published on 2021-11-242022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activity Affect Analysis Anti-SARS-CoV-2 Activity antiviral activity antivirals AutoDock binding affinity binding energy clinical trial Compound compounds coronavirus 2 COVID-19 COVID-19 pandemic demonstrated docked docking scores effective glycyrrhiza glycyrrhizic acid glycyrrhizin half-maximal inhibitory concentration highlight IC50 in vivo inhibited investigation licorice Ligand M pro MD simulation multiple mechanism plant Post-infection protease public health Replication respiratory robust SARS-CoV-2 SARS-CoV-2 replication Saudi Arabia screened stability Support the SARS-CoV-2 therapeutic options Treatment Treatment protocol viral infection Viral protein yielding [DOI] 10.3390/ph14121216 PMC 바로가기 [Article Type] Article
Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?감초의 항 바이러스 활동이 CovID-19 감염과 싸울 수 있습니까?Review Published on 2021-06-082022-09-10 Journal: Biomolecules [Category] MERS, SARS, 치료제, [키워드] ACE2 activity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory antioxidant effect antioxidant effects antiviral properties antiviral property Can can not Cell chymotrypsin clinical trials component components Compound coronavirus COVID-19 COVID-19 disease COVID-19 emergency cysteine cysteine protease docking study enoxolone excluded feature Glycyrrhetinic acid glycyrrhiza glycyrrhizic acid glycyrrhizin Host in viral indicated interfere licorice liquorice membranes nonspecific pandemic pharmacological Replication reported SARS Coronavirus SARS-CoV-2 Serine Spike protein Spread supported the SARS-CoV-2 transmembrane serine protease Viral virus virus entry viruses [DOI] 10.3390/biom11060855 PMC 바로가기 [Article Type] Review
Effects of Licorice on clinical symptoms and laboratory signs in moderately ill patients with pneumonia from COVID-19: A structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-09-152022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 Adverse reaction age allergy Anti-inflammatory Antibody test anticipated antiviral therapy assigned Bandar Abba Bandar Abbas Blinding Breastfeeding C-reactive protein Chest computed tomography chronic heart disease clinical clinical study clinical symptom Clinical symptoms clinical trial company conducted Confirmed Control control group Corticosteroids COVID-19 criteria Critical diagnosis of SARS-CoV-2 Diseases disorders dissemination diuretics dose drugs dry cough education Effect element evaluated feature Features female patient Fever glycyrrhiza history hospital Hospitalization hypertension ill patient incidence Infection inhibitor intervention group Iran Laboratory Laboratory signs licorice liquorice liver lymphocytopenia male Medical Sciences Ministry of Health Moderate COVID-19 number objective Open-label outcome parallel-group participant Patient pharmaceutical Placebo Pneumonia polymerase chain Primary outcome protocol random randomization randomize Randomized Randomized controlled trial regimen Registered registry renal Sample size screened secondary outcome selective serotonin reuptake inhibitor Seven single-center standard treatment status Study protocol therapeutic Thyroid time tiredness Treatment treatment arm Trial university Version website X-ray [DOI] 10.1186/s13063-020-04706-3 PMC 바로가기 [Article Type] Letter
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathwayArticle Published on 2020-05-082022-11-01 Journal: International immunopharmacology [Category] Coronavirus, [키워드] Activation alleviate anti-inflammatory agent antibody clinical setting cured cytokine deficiency disease downstream Glycyrrhetinic acid glycyrrhizic acid hepatic injury Hepatitis HMGB1 HMGB1 release human disorder hydrolysis immunological in viral Infection Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory response ingredient inhibit inhibited injection Injury involved licorice mechanism MHV mice murine murine hepatitis virus Neutralizing neutralizing antibody occur provide Regulation reported Signaling signaling pathway significantly TCM the cytokine storm therapy TLR4 Treatment triggered variety Viral hepatitis viral-induced [DOI] 10.1016/j.intimp.2020.106578 PMC 바로가기 [Article Type] Article