Recent advances in applying G-quadruplex for SARS-CoV-2 targeting and diagnosis: A reviewArticle Published on 2022-11-302022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 변종, 치료기술, 치료제, [키워드] accumulating addressed antiviral drug Care caused coronavirus SARS-CoV-2 diagnostic functions G-quadruplex Health Host Immune escape Intervention Ligand ligands neutralizing antibody nucleic acid pandemic polymerases protease Protein question recent regulate SARS-CoV-2 SARS-CoV-2 detection Structure targeting Treatment strategies Vaccine variant virus [DOI] 10.1016/j.ijbiomac.2022.09.152 PMC 바로가기
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
The pH Robustness of Bacterial SensingArticle Published on 2022-10-262022-11-16 Journal: mBio [Category] 유전자 메커니즘, [키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction Signaling TAR tested ultracentrifugation was obtained [DOI] 10.1128/mbio.01650-22 PMC 바로가기
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningArticle Published on 2022-10-182022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral drug applicability assays atomic resolution caused consequence Consequences conserved coronavirus CoV COVID-19 cross-binding effects Degradation drug design effective Efficiency expression fragment-based X-ray screening functional Health Host host mRNA IFN infection rate inhibitor interferon ligands limitation MERS coronaviruses mortality rate N-terminal domain non-structural protein non-structural protein 1 outbreak pandemic Pathways Protein provide Replication respiratory Revealed Safe SARS-CoV-2 Screening Site starting point Structure-based drug design unique vaccination Vaccines variety virulence virus X-ray X-ray crystallography [DOI] 10.3390/ijms232012448 PMC 바로가기
NMR Observation of Sulfhydryl Signals in SARS-CoV-2 Main Protease Aids Structural StudiesArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL pro AID aliphatic AlphaFold-Multimers amide antiviral drug target backbone binding Combination competitive binding drug design effective experiment High-resolution homodimeric identify Interaction Ligand ligand binding ligands M pro Mpro/3CLPro N-terminal NMR NMR spectroscopy peptides protease Protein protons remained reveal SARS-CoV-2 sequence signal solvent sulfhydryl thiol group variant [DOI] 10.1002/cbic.202200471 PMC 바로가기
Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligandsArticle Published on 2022-10-012022-11-15 Journal: Febs Letters [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral therapeutics bind Cell complexes Compound cytotoxicity drug delivery enveloped virus fatty Fatty acid hydrophobic inhibitors Ligand ligands lipid-binding protein mechanism membrane membrane disruption. membranes modulated neutralize Protein replaced resulting SARS-CoV-2 Therapeutic compounds unsaturated viruses [DOI] 10.1002/1873-3468.14456 PMC 바로가기
Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic ApproachArticle Published on 2022-09-142022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] Activation Antiviral assist binding cascade cell damage cell membrane components COVID-19 COVID-19 infection Cytokines Defense downregulate drug expression facilitate food help highlight host cells immune immune signature immune system in viral Infection Inflammation inflammatory chemokine Inflammatory response innate immune response innate immune system interfere intracellular signaling involved ligands mechanism mediation modulate molecular pathogen invasion pathogenic Protein recognizing responsible RNA SARS-CoV-2 signaling pathway therapeutic agent Therapeutic approach TLR TLR agonists TLRs Toll-like receptor type 1 interferon [DOI] 10.3390/ijms231810716 PMC 바로가기
In silico investigation of ACE2 and the main protease of SARS-CoV-2 with phytochemicals from Myristica fragrans (Houtt.) for the discovery of a novel COVID-19 drugResearch article Published on 2022-09-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 치료제, [키워드] ACE2 acute respiratory syndrome AutoDock binding energy cause Compound compounds coronavirus coronavirus disease COVID-19 COVID-19 pandemic criteria docking effective examined FIVE include Interaction Ligand ligands Medicine molecular molecular docking molecular dynamics MPro Myristica fragrans (houtt.) New coronavirus pharmacokinetics Potential protease PSD reported Research SAR-CoV-2 main protease SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro SARs-CoV-2 spike-ACE-2 solvent specific treatment the SARS-CoV-2 therapeutic potential therapeutic target these compound Treatment virus was selected were used Wuhan, China [DOI] 10.1016/j.sjbs.2022.103389 [Article Type] Research article
Anti-HIV-drug and phyto-flavonoid combination against SARS-CoV-2: a molecular docking-simulation base assessmentSARS-CoV-2에 대한 항 HIV 약물 및 식물성 플라보노이드 조합: 분자 도킹 시뮬레이션 기반 평가Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] acute respiratory syndrome Analysis anti-HIV drug anti-HIV drugs Anti-inflammatory antimalarial drug Antimalarial drugs Antiviral clinical evidence Combination combination therapy combined effect complex coronavirus darunavir docking docking score drug drug-likeness eight enzyme flavonoid genome replication H-bond Health Hypothesis in viral individual Ligand ligands M pro MM/PBSA molecular molecular docking Molecular docking study molecular docking-simulation Patient phyto-flavonoid prophylactic therapy protease Protease inhibitor quercetin respiratory RMSF SARS-CoV-2 selected selective Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stability viral genome replication [DOI] 10.1080/07391102.2021.1885495 PMC 바로가기 [Article Type] Article