Differential avidity determination of IgG directed towards the receptor-binding domain (RBD) of SARS-CoV-2 wild-type and its variants in one assay: Rational tool for the assessment of protective immunityArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome avidity binding coronavirus IgG IgG RBD Infection LINE mandatory marker mRNA much lower Omicron variant Protective protective immunity RBD reached Receptor-binding domain recom Line SARS-CoV-2 IgG. SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection serology Spike protein the receptor-binding domain vaccination variant wild-type WT SARS-CoV-2 [DOI] 10.1002/jmv.28006 PMC 바로가기
A Path-Based Analysis of Infected Cell Line and COVID-19 Patient Transcriptome Reveals Novel Potential Targets and Drugs Against SARS-CoV-2감염된 세포주 및 COVID-19 환자 전사체의 경로 기반 분석을 통해 SARS-CoV-2에 대한 새로운 잠재적 표적 및 약물 공개Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ADCY2 ADSL Against anti-SARS-CoV-2 ATP bemcentinib biological network BUB1 Cell cell line cell lines central gene central genes changes Concordance conivaptan COVID-19 COVID-19 severity curated DEGs DEGs (Differentially Expressed Genes) Differentially expressed genes drug drugs targeting dysregulated e genes G1/S transition Genes greater identify Infection leukocyte leukocyte activation LINE metabolic process Migration MOST network analysis novel OCRL PBK PBMC PBMCs PBMCs (Peripheral Blood Mononuclear Cells) peripheral Peripheral blood Peripheral blood mononuclear cells phthalocyanine Potential reveal SARS-C0V-2 SARS-CoV-2 SARS-COV-2 infection severity target target gene TIAM1 Transcriptome transcriptomic viruses with COVID-19 [DOI] 10.3389/fimmu.2022.918817 PMC 바로가기 [Article Type] Article
A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron VariantsACE2 및 TMPRSS2를 발현하는 새로 설계된 A549 세포주는 Delta 및 Omicron 변이체를 포함하여 SARS-CoV-2에 매우 관대합니다.Article Published on 2022-06-232022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A549 A549 cell A549 cells ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antivirals breakthrough infections can be used Cell coronavirus Critical Culture Delta delta and omicron variants drugs EIDD-1931 Express expressed expressing Factor Host human ACE2 human cell identify Including Infection infection with SARS-CoV-2 inhibit SARS-CoV-2 lack LINE nelfinavir New Nirmatrelvir omicron Omicron variants Permissive Remdesivir respiratory Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serine severe acute respiratory syndrome Coronavirus Spike protein susceptible the SARS-CoV-2 TMPRSS2 transcript transducing transmembrane serine protease transmembrane serine protease 2 variant Viral viral entry virus infections [DOI] 10.3390/v14071369 PMC 바로가기 [Article Type] Article
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment증례 보고: SARS-CoV-2 감염이 오래 지속된 APDS 환자 1명에서 단일클론항체로 성공적인 치료Case Reports Published on 2022-06-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] activated activated PI3K delta syndrome (APDS) administration affected APDS clearance COVID19 described Efficacy first positive genotyping IEI Infection LINE long-lasting long-lasting infection monoclonal monoclonal antibodies monoclonal antibody multiple therapeutic agent multiple therapeutic agents neutralizing monoclonal antibodies other treatments Patient pauci-symptomatic PI3K Prolonged reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Swab syndrome tested the SARS-CoV-2 virus therapeutic agents Tolerability treated Viral viral shedding virus wild type [DOI] 10.3389/fimmu.2022.891274 PMC 바로가기 [Article Type] Case Reports
Comparison of SARS-CoV-2 Evolution in Paediatric Primary Airway Epithelial Cell Cultures Compared with Vero-Derived Cell LinesArticle Published on 2022-02-052022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] Adults age airway arising Cell Cell culture cell lines cells changes in children cleavage site co-morbidities Cohort Culture Delta dependent on driving epithelial Evidence Evolution Factor fixation Genetic genetic diversity genotypic growth highlight Host host cell factor host cells human respiratory epithelium in vitro infect isolate isolates LINE morbidity and mortality Mutation nasal passages phenotypic plasticity polybasic primary airway epithelial cells reduced remained respiratory epithelial cells resulting SARS-CoV-2 SARS-CoV-2 evolution several variant spike Strains variant Vero Vero cells viral evolution Virus evolution VoC whole-genome sequencing [DOI] 10.3390/v14020325 PMC 바로가기 [Article Type] Article
Commentary: Pattern Recognition Proteins: First Line of Defense Against CoronavirusesImmunology Published on 2022-01-262022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] adult respiratory distress syndrome Against Bronchoalveolar lavage COVID-19 LINE pattern Recognition SARS CoV 2 surfactant protein-D viral aggregation [DOI] 10.3389/fimmu.2022.815168 PMC 바로가기 [Article Type] Immunology
Understanding Telemedicine’s “New Normal”: Variations in Telemedicine Use by Specialty Line and Patient DemographicsOriginal Research Published on 2022-01-012022-10-29 Journal: Telemedicine journal and e-health : the official journal of the American [Category] Coronavirus, SARS, [키워드] African American age baseline calculated coronavirus disease COVID-19 demographic characteristics demographics Dermatology difference Factor Female patients health equity health system implementation in-person visit initial less LINE male material older patient pandemic Patient primary care promote provide psychiatry returned risk ratio Sex synchronous telehealth Telemedicine understanding Variation Volume younger patients [DOI] 10.1089/tmj.2021.0041 PMC 바로가기 [Article Type] Original Research
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging VirusesMinireview Published on 2021-12-212022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiviral drugs approach approved category A-C pathogens caused clinical disease Clinical efficacy clinical testing clinical trial Combination Contact coronavirus coronavirus disease countermeasures COVID-19 develop drug drug combination drug resistance drug synergy early treatment Ebola virus effective Efficacy effort emerging virus endpoints ENhance highest in vitro indications infected individual lack likelihood limit LINE model-driven approach Novel coronavirus Other pandemic pandemic preparedness Pandemics Prophylaxis regimen SARS-CoV-2 synergistic therapeutic Toxicity treatments for COVID-19 Vaccine viral pandemic viral pathogen viral pathogens virus while [DOI] 10.1128/mbio.03347-21 PMC 바로가기 [Article Type] Minireview
What Is the Role of Pharmacists in Treating COVID-19 Patients? The Experiences and Expectations of Front Line Medical StaffPublic Health Published on 2021-12-202022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] activity Adverse drug reactions analyzed Care Chinese Clinical use complex contraindications COVID-19 Drug interactions drugs expectation experience growth help information Isolation LINE medical staff medication Nurse patients Perspective Pharmacist pharmacists physician play a role positive provided qualitative research role therapy treating treating COVID-19 patient was used [DOI] 10.3389/fpubh.2021.778863 PMC 바로가기 [Article Type] Public Health
The Psychological Impact of COVID-19 on Front Line Nurses: A Synthesis of Qualitative EvidenceReview Published on 2021-12-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] added Anxiety Care carried cause Cochrane Library COVID-19 COVID-19 pandemic Depressive symptoms English Evidence front line healthcare professionals Hospitalized Impact impacts IMPROVE infecting LINE Nurse Nurses Other pandemic Pandemics people with COVID-19 Psychological distress psychological Impact PsycINFO Qualitative qualitative research recommendation reduce social isolation Spanish Stress Support synthesis systematic review Topic Web of Science [DOI] 10.3390/ijerph182412975 PMC 바로가기 [Article Type] Review