Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN studyArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infection [Category] SARS, 진단, 치료기술, [키워드] age analysed anti-S anti-SARS-CoV-2 antibody association Case-control case-control study controls correlated fixed Gender identify Immunity Increasing infected individual Infection Linear regression Live virus logistic regression models Neutralising Antibodies no difference nucleocapsid occurred performed pre-vaccination protective effect pseudovirus reduced risk Reinfection required Result SARS-CoV-2 SARS-CoV-2 serology serological serology serum sample significantly lower SIREN study tested titre titres vaccination Wuhan [DOI] 10.1016/j.jinf.2022.09.004 PMC 바로가기
Graphene-Binding Peptide in Fusion with SARS-CoV-2 Antigen for Electrochemical Immunosensor ConstructionArticle Published on 2022-10-172022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody detection Antibody titers Antigen applied caused characterized conditions construction decrease demonstrated detect diagnosing Diagnosis diagnostic DPV Efficiency electrochemical immunosensor emerging disease Fourier transform fusion Graphene human serum increase in Infection limit of detection Linear regression Microscopy peptide platform positive probe pulse Raman spectroscopy reduced response resulting S protein SARS-CoV-2 SARS-CoV-2 antibodies SBP SEM sera solid-binding peptide (SBP). tested the SARS-CoV-2 the SARS-CoV-2 virus traditional method was performed was used [DOI] 10.3390/bios12100885 PMC 바로가기
Comparison of antibody response durability of mRNA-1273, BNT162b2, and Ad26.COV2.S SARS-CoV-2 vaccines in healthcare workersArticle Published on 2022-10-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] Ad26.COV2.S Administered age analysis of variance Anti-spike anti-spike antibody antibody level Antibody Response Antibody responses blood draws BNT162b2 BNT162b2 vaccine booster dose COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccinations Effectiveness enzyme-linked immunosorbent female group healthcare worker Immunosuppression interquartile range IQR Linear regression median mRNA-1273 mRNA-1273 vaccine neutralizing antibody outcome participant Participants Primary outcome SARS-CoV-2 SARS-CoV-2 vaccine significantly significantly higher vaccination Vaccine vaccine effectiveness variable [DOI] 10.1016/j.ijid.2022.08.022 PMC 바로가기
Individual Factors Including Age, BMI, and Heritable Factors Underlie Temperature Variation in Sickness and in Health: An Observational, Multi-cohort StudyObservational Study Published on 2022-09-012022-10-04 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 임상, [키워드] 95% confidence interval ACE acute infection Admission Affect age aging Analysis association basal BMI body mass index characteristic Community-based cohort contribute COVID COVID-19 COVID-19 infection Effect examined Factor Fever Genetic Health healthy heritability hospital identify Immunesenescence Immunity Including increasing age individual Infection less Linear regression London multivariable multivariable logistic regression observation Older participant Participants positive RT-PCR ROC RT-PCR SARS-CoV-2 SARS-COV-2 infection saturated Sensitivity and specificity Sex temperature temperature regulation Thermoregulation threshold TwinsUK variable volunteers was used [DOI] 10.1093/gerona/glab295 PMC 바로가기 [Article Type] Observational Study
Correlation between In Vitro Neutralization Assay and Serological Tests for Protective Antibodies DetectionArticle Published on 2022-08-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, [키워드] 2019-nCoV Accuracy alternative method analyses antibodies assays Biosafety Level 3 coefficients correlation detection diagnostics Elecsy ELISA Epidemiological study Epidemiology Euroimmun gold standard highest humoral Humoral immunity IgG immunoassay individual Kappa coefficient Linear regression neutralizing antibody operators outcome Pearson performed plaque reduction neutralization plaque reduction neutralization test (PRNT) positive Predictive PRNT Protective antibody protective immunity reference method ROC ROC Curve Roche S-RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S sensitivity serological serological test serum samples Spearman Spearman coefficient specificity Spread surrogate virus neutralization test (sVNT). sVNT Test virus neutralization test [DOI] 10.3390/ijms23179566 PMC 바로가기
A panel regression analysis for the COVID-19 epidemic in the United States미국의 COVID-19 전염병에 대한 패널 회귀 분석Article Published on 2022-08-192022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] addition Analysis analyzed capita Cluster correlated COVID-19 COVID-19 epidemic dose Effect Epidemic event Factor implementation incidence rate Incubation period Linear regression MOST omicron positively correlated promotion regression analysis robust significantly Spread spread of COVID-19 Strains Support the epidemic the United State vaccination Vaccination Status variant weather [DOI] 10.1371/journal.pone.0273344 PMC 바로가기 [Article Type] Article
A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers인간 혈장에서 항 바이러스 전구 약물 Molnupiravir의 결정을위한 검증 된 LC-MS/MS 방법 및 건강한 이집트 자원 봉사자들의 약동학 적 모델링 연구에 대한 적용Article Published on 2022-08-152022-08-31 Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] acetic acetic acid acetonitrile Agilent analyte analyzed Antiviral approach AUC C max Concentration confidence interval detection determine develop dosage dose Eclipse Efficacy ESI evaluate extraction FDA flow rate geometric mean geometric mean ratios Geometric means GMR Guidance healthy healthy volunteer healthy volunteers Human plasma LC-MS/MS Linear regression linearity m/z mass spectrometer mass spectrometry maximum concentration metabolite mixture molnupiravir N-hydroxycytidine NHC pharmacokinetic pharmacokinetic data plasma Population Population Pharmacokinetic Modeling positive protein precipitation pumped recommendation required ribavirin SARS-CoV-2 Simulation solvent subjects therapeutic target therapeutic targets Treatment triple quadrupole mass spectrometer United State United States Volunteer was performed was used were used [DOI] 10.1016/j.jchromb.2022.123363 PMC 바로가기 [Article Type] Article
Multi-disciplinary community respiratory team management of patients with chronic respiratory illness during the COVID-19 pandemicObservational Study Published on 2022-08-132022-10-04 Journal: NPJ Primary Care Respiratory Medicine [Category] 임상, 치료법, [키워드] Admission Admissions analysed benefit carried chronic obstructive chronic respiratory chronic respiratory disease Community correlated COVID-19 pandemic death Electronic health record highest Hospital admission implementation Infection Interaction Linear regression management Mortality NHS nosocomial COVID-19 occurred outcome pathway Pathways Patient Poisson model proportion pulmonary disease Rate reducing reduction in respiratory response secondary care severity significant decrease significantly higher team Triage Trust [DOI] 10.1038/s41533-022-00290-y PMC 바로가기 [Article Type] Observational Study
Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes임신성 SARS-CoV-2 감염은 면역 및 영양막 유전자의 태반 발현과 관련이 있습니다Article Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence age Analysis antibody Birth CGB3 change contribute correlation CXCL10 DDX58 decreased expression during pregnancy Effect evaluate expression feature Features fetus Fisher Gene Expression Generation gestational age group groups Health histologic Histopathology IgG IgG antibody immune immune gene immune genes increased expression Infant Infants Linear regression linear regression models Maternal median molecular Mount Sinai Mount Sinai Health System NanoString nasal swab New York City no significant differences not differ offspring outcome participant Participants performed Placenta placental Placentas positive positive RT-PCR Pregnancy pregnant prospective cohort study PSG3 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-COV-2 infection serology test severe disease significant difference significant differences Spearman statistical analyses System term the SARS-CoV-2 TLR3 Transmission vertical transmission [DOI] 10.1016/j.placenta.2022.06.017 PMC 바로가기 [Article Type] Article
Pharmacogenetic variants and risk of remdesivir-associated liver enzyme elevations in Million Veteran Program participants hospitalized with COVID-19COVID-19로 입원한 백만 재향 군인 프로그램 참가자의 약물 유전적 변이 및 렘데시비르 관련 간 효소 상승 위험Article Published on 2022-08-012022-09-11 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted administration age Alanine alanine aminotransferase ALT assigned association baseline black Comorbidities components conducted coronavirus disease Coronavirus disease 2019 COVID-19 CYP2C19 drug Drug administration Elevation enzyme food Hospitalized Linear regression liver enzyme liver enzymes log-transformed Million Veteran Program multifactorial multivariable model participant Participants Patient pharmacogenetic phenotype receiving Remdesivir retrospective risk Sex stratified Treatment treatment initiation variant was performed white with COVID-19 [DOI] 10.1111/cts.13313 PMC 바로가기 [Article Type] Article