15-Year progression to liver cancer in the lack of treatment for lysosomal acid lipase deficiency: A case reportArticle Published on 2022-09-022022-11-16 Journal: Medicine [Category] 변종, [키워드] acid lipase deficiency age cardiovascular complications Case report change characterized Cholangiocarcinoma cholesteryl ester cirrhosis coronavirus disease COVID-19 Deterioration diagnosed Diagnosis enzyme fibrosis Follow-up genetic disorder HCC Hepatocellular carcinoma hepatocyte higher risk IMPROVE individual Kupffer cells Laboratory lack LIPA liver Liver cancer Liver damage Liver function lysosomal male malignancy Mutation Neoplasms nodule pandemic Patient progression reduce reported Sebelipase alfa steatosis therapy tissues treat treated Treatment Triglyceride variant worsening [DOI] 10.1097/MD.0000000000030315 PMC 바로가기
Inhibition of Autolysis by Lipase LipA in Streptococcus pneumoniae Sepsis스트렙토코쿠스 뉴모니아에 세균혈증에서 리파제 LipA에 의한 자가 용해 억제Article Published on 2017-12-312024-08-24 Journal: Molecules and Cells [Category] 폐렴구균 감염증, [키워드] Infection LIPA LytA S. pneumoniae Sepsis
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease대규모 유전자 중심 분석으로 관상동맥 질환에 대한 새로운 변종 식별Research Article Published on 2011-09-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABCG5 ABCG8 aetiology Affect allele Analysis array Artery Asians association association tests Author biochemical CAD candidate gene cardiovascular disease cellular characterized COL4A1 COL4A2 common variants complement conducted Control controls Coronary Coronary artery Coronary artery disease custom-designed array customised gene array CYP17A1 disease Effect European Europeans Evidence evidence of examined except for found Frequency function functional variant functional variants Gene Gene Expression Genes Genetic Genetic variant genome-wide association genotyped GWA heart disease help heterogeneity identify IL5 LIPA loci low frequency LPA majority mechanism not differ novel novel association novel associations Odds ratio Potential potential mechanism potential mechanisms replicate Replication reported risk risk factor South South Asian suggested supported susceptibility susceptibility loci target tested therapeutic interventions TRIB1 variant variants Vascular ZC3HC1 [DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article