Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infectionArticle Published on 2024-06-172024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Acute inflammation antimicrobial peptide Antimicrobial responses Cathelicidin hCAP-18 Host defence peptide Innate immunity LL-37 Microbiome nasal respiratory respiratory syncytial virus Viral host response viral infection [DOI] 10.1038/s41598-024-64446-1 PMC 바로가기 [Article Type] Article
The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity Research Published on 2022-06-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] Analysis antimicrobial peptide association Blood correlation COVID-19 patient COVID-19 progression Critical CRP demonstrated disease severity Effect Evidence expression granulocyte group Hospital admission IL-6 Inflammation investigated Laboratory parameters LDH leucocyte leukocyte LL-37 Patient PCT produced progression released risk of COVID-19 SARS-CoV-2 serum Serum level severity severity of COVID-19 significantly stimulate Vitamin D vitamin D serum with COVID-19 [DOI] 10.1038/s41598-022-13260-8 [Article Type] Research
Salivary immunity of elite collegiate American football players infected with SARS-CoV-2 normalizes following isolation Research Published on 2022-05-312022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] AMPs average Biomarker changes in characterized complex Concentration Control COVID-19 COVID-19 infection defensin determine Effect General population greater groups Human Immunity infected with SARS-CoV-2 Infection Isolation lactoferrin LL-37 Lung inflammation positive Protein remained risk salivary SARS-CoV-2 secretion t-test tested uninfected were measured were used [DOI] 10.1038/s41598-022-12934-7 [Article Type] Research
Role of LL-37 in thrombotic complications in patients with COVID-19Article Published on 2022-05-212023-07-09 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), [키워드] Coagulation factors COVID-19 Hypercoagulation LL-37 SARS-CoV-2 [DOI] 10.1007/s00018-022-04309-y PMC 바로가기
Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce MicrothrombosisArticle Published on 2022-05-122023-06-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, [키워드] alpha synuclein Cathelicidin COVID-19 diabetes LL-37 NET clearance neutrophil extracellular trap (NET) SARS-CoV-2 [DOI] 10.3389/fimmu.2022.880961 PMC 바로가기
An in silico scientific basis for LL-37 as a therapeutic for Covid-19Article Published on 2022-05-012023-07-06 Journal: Proteins [Category] COVID19(2023년), [키워드] COVID-19 in silico structural analysis LL-37 molecular docking therapeutic Vitamin D [DOI] 10.1002/prot.26198 PMC 바로가기
Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity항바이러스 선천 면역에서 비타민 D 유도 항균 펩티드의 새로운 역할Review Published on 2022-01-112022-09-10 Journal: Nutrients [Category] 유전자 메커니즘, 치료제, [키워드] 25-hydroxyvitamin D active form AMP AMPs antibacterial activity antibacterial immunity antimicrobial antimicrobial peptide antimicrobial peptides antiviral immunity antiviral responses Bacterial binding calcifediol calcitriol CAMP caries Cathelicidin characterized circulating component components contribute coronavirus COVID-19 COVID-19 pandemic cytokine cytokine network Cytokines defensin Dental caries elements etiological agent Evidence Gene Expression Human immune Immune cell immune cells in vitro in vivo increased risk indication induce Infection Innate Innate immune cells Innate immunity LL-37 pathogen Pattern recognition Pattern recognition receptors peptide peptides potential mechanism potential mechanisms provided regulate role SARS-CoV2 secondary structures secretion Signaling stimulated Transcription transcription factor urinary tract infections VDR Viral Vitamin Vitamin D vitamin D deficiency Vitamin D receptor β-defensin [DOI] 10.3390/nu14020284 PMC 바로가기 [Article Type] Review
Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 PatientsArticle Published on 2022-01-012022-11-16 Journal: Journal of innate immunity [Category] 치료기술, [키워드] acute respiratory syndrome age antimicrobial peptide Cohort consequence COVID-19 COVID-19 patient COVID-19 patients Degradation described detectable detrimental DNase efficient clearance elderly elderly male extracellular DNA extracellular trap extracellular traps Factor Female patients fiber healthy controls higher risk Host identify Impaired inefficient Infection LL-37 male marker negative correlation NET NETs neutrophil Neutrophil extracellular traps occur Patient patients plasma potential risk reduced released risk severe COVID-19 thrombosis Thrombotic complications [DOI] 10.1159/000521594 PMC 바로가기
Age-Related Expression of IFN-λ1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected IndividualsImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] age Ageing analyzed Anti-viral Antiviral Asymptomatic Comorbidities COVID - 19 defensin effective expression expression pattern form forms Gender groups heterogeneous Host identify IFITM1 IFITM3 IFN - interferon IFN-I IFN-α IFN-β IFN-λ1 individual induce infected with SARS-CoV-2 Infection innate immune innate immune response Innate immunity interferon interferon-stimulated gene intrinsic LL-37 Local modulation mRNA expression mRNA level mucosa mucosal mucosal immunity nasopharyngeal nasopharyngeal mucosa Nasopharyngeal swab occur pediatric peptide Primary infection protective role Protein reached SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection selected selective subject subjects susceptibility symptomatic Symptoms the SARS-CoV-2 triggered type I type III upregulated upregulation virus β-defensin [DOI] 10.3389/fimmu.2021.750279 PMC 바로가기 [Article Type] Immunology
Neutrophil Extracellular Traps Contribute to COVID-19 Hyperinflammation and Humoral Autoimmunity호중구 세포외 트랩은 COVID-19 과염증 및 체액성 자가면역에 기여합니다Article Published on 2021-09-262022-09-12 Journal: Cells [Category] SARS, 진단, [키워드] addressed antibody antinuclear antibody autoantibodies autoimmune responses complexes confocal microscopy contribute coronavirus disease correlated COVID-19 COVID-19 patient Critical cytokine cytokine level cytoplasmic Degradation DNA-complex DNase and autoimmunity ELISA evaluated flow cytometry granulocyte HMGB1 inducer inflammatory markers ISG-15 LDG LL-37 low-density macrophages NET NETs Neutrophils pro-inflammatory proportion Protein quantified SARS-CoV-2 secretion serum severe patients severity Structure supernatant was used [DOI] 10.3390/cells10102545 PMC 바로가기 [Article Type] Article