Electrophysiological Profile of Different Antiviral Therapies in a Rabbit Whole-Heart ModelResearch Published on 2024-06-082024-09-05 Journal: Cardiovascular toxicology [Category] update2024, [키워드] Anitviral arrhythmia Azithromycin Hydroxychloroquine Long QT syndrome Lopinavir Remdesivir sudden cardiac death [DOI] 10.1007/s12012-024-09872-3 PMC 바로가기 [Article Type] Research
Population pharmacokinetic analysis of lopinavir in HIV negative individuals exposed to SARS-CoV-2: a COPEP (COronavirus Post-Exposure Prophylaxis) sub-studyarticle Published on 2023-09-272024-09-05 Journal: BMC Pharmacology & Toxicology [Category] update2024, [키워드] COVID Lopinavir NONMEM Pharmacometrics Therapeutic Drug Monitoring [DOI] 10.1186/s40360-023-00687-6 PMC 바로가기 [Article Type] article
Antivirals for prevention of hepatitis B virus mother‐to‐child transmission in human immunodeficiency virus positive pregnant women co‐infected with hepatitis B virusarticle Published on 2023-06-122024-09-05 Journal: The Cochrane database of systematic reviews [Category] update2024, [키워드] Antiviral agents Coinfection DNA, viral emtricitabine female Hepatitis B e antigens Hepatitis B virus HIV HIV infections HIV seropositivity humans Infant Infectious Disease Transmission, Vertical lamivudine Lopinavir Pregnancy pregnant women Ritonavir tenofovir zidovudine [DOI] 10.1002/14651858.CD013653.pub2 PMC 바로가기 [Article Type] article
Lopinavir/ritonavir for treatment of non-hospitalized patients with COVID-19: a randomized clinical trialRandomized Controlled Trial Published on 2023-03-012023-07-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), [키워드] Antiviral clinical trial COVID-19 Lopinavir Outpatient Ritonavir [DOI] 10.1016/j.ijid.2022.12.028 PMC 바로가기 [Article Type] Randomized Controlled Trial
Design and synthesis of novel phe-phe hydroxyethylene derivatives as potential coronavirus main protease inhibitorsArticle Published on 2022-10-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral caused clinical trial Compound conducted coronavirus COVID-19 COVID-19 patients derivative docking score example Lopinavir molecular molecular docking molecular dynamic simulation molecular dynamics MPro pandemic protease inhibition Protease inhibitor SARS-CoV-2 stability synthesis [DOI] 10.1080/07391102.2021.1905549 PMC 바로가기
Integrated bioinformatics-cheminformatics approach toward locating pseudo-potential antiviral marine alkaloids against SARS-CoV-2-MproSARS-CoV-2-Mpro에 대한 유사 잠재적 항바이러스 해양 알칼로이드를 찾기 위한 통합 생물정보학-화학정보학 접근Article Published on 2022-09-012022-09-11 Journal: Proteins [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 added Alpha analyzed Antiviral antiviral marine alkaloids approach ATB AutoDock B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding energy candidate carried complex complexes contagious Coronavirus-2 darunavir docking docking study drug drug-likeness drug-likeness profiles prediction Entropy enzyme exhibit free energy H-bond highest Initially investigated Ligand literature review Lopinavir lowest MD simulation MM/PBSA molecular molecular docking molecular docking simulation molecular dynamics Molecular mechanics Molecular Orbital morbidity morbidity and mortality MPro omicron pharmacokinetics pharmacological physicochemical predicted profile profiles protease Protein Protein Data Bank retrieved RMSD RMSF SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2-Mpro. surface area thermodynamic Topology Toxicity variants Virtual screening were assessed were recorded [DOI] 10.1002/prot.26341 PMC 바로가기 [Article Type] Article
Efficacy of pharmacological interventions in COVID-19: A network meta-analysisCovid-19의 약리학 적 개입의 효능 : 네트워크 메타 분석Meta-Analysis Published on 2022-09-012022-09-08 Journal: British Journal of Clinical Pharmacology [Category] meta-analysis, 임상, 치료제, [키워드] 95% confidence interval Administered analysed Clinical improvement clinical recovery Controlled trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database Dexamethasone drug Favipiravir followed by head Head-to-head comparison Hydroxychloroquine increase interferon Intervention investigator Lopinavir Lopinavir/ritonavir lower mortality lower risk lower risk of mortality MeSH term moderate to severe Mortality Network meta-analysis Occurrence patients with moderate pharmacological intervention Quantitative analysis Randomized controlled trial reduce reduced Relative risk Remdesivir risk Ritonavir screened Serious Adverse Event Serious Adverse Events severe COVID-19 significantly Standard of care Tocilizumab was performed [DOI] 10.1111/bcp.15338 PMC 바로가기 [Article Type] Meta-Analysis
Repurposing drugs and identification of inhibitors of integral proteins (spike protein and main protease) of SARS-CoV-2SARS-CoV-2의 필수 단백질(스파이크 단백질 및 주요 프로테아제) 억제제의 용도 변경 및 식별Article Published on 2022-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Analysis binding energy Cefoperazone Clinical use Compound Coronavirus infection COVID-19 docked domain drug effort EGCG Emergency exhibited FIVE glycoprotein GRN HCQ Hydroxychloroquine identify Infection inhibitor inhibitors inhibitors of SARS-CoV-2 Inhibitory effects Lopinavir LPV M pro main protease enzyme MDs molecular molecular docking molecular dynamic simulations MPro nelfinavir outbreak predicted protease Protein Public public health emergency RBD RDV Receptor-binding domain recorded Remdesivir repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein screened spike (S) glycoprotein Spike protein were used WHO World Health Organisation Zafirlukast [DOI] 10.1080/07391102.2021.1886993 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and Plasmodium falciparum Co-Infection in a Returning Traveler돌아오는 여행자의 SARS-CoV-2 및 Plasmodium falciparum 공동 감염Article Published on 2022-08-052022-09-11 Journal: Frontiers in Public Health [Category] SARS, 말라리아, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Anxiety Arbidol China Co-infection Compound coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Diagnosis diazepam dihydroartemisinin discharge discharged Diseases Evidence evidence of health system Healthcare system Hospitalization hydrochloride inflammatory reactions Insomnia interferon Lopinavir LOPINAVIR AND RITONAVIR malaria Mental no evidence of offer P. falciparum pandemic Paroxetine Paroxetine Hydrochloride Piperaquine Plasmodium Plasmodium falciparum raise reported Ritonavir SARS-CoV-2 severe acute respiratory syndrome Coronavirus sub-Saharan Africa Tablet tablets Tartrate tested the patient thymosin Treatment vital sign zolpidem Zolpidem Tartrate [DOI] 10.3389/fpubh.2022.871374 PMC 바로가기 [Article Type] Article
Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: An in-silico approachSARS-COV-2에 대한 내생 세균의 2차 대사 산물의 생리 활성 가능성: In-silico 접근Article Published on 2022-08-042022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, 치료제, [키워드] 3CLpro accelerate accession number aligned ammonia analyses Analysis analyzed antioxidant approach associations Bacillus Bacteria Bacterial biochemically chymotrypsin Chymotrypsin-like protease collected Compound computational tool coronavirus Culture docked docking scores drug-likeness effective enzyme flask culture flavonoid GenBank identify in silico analysis in-silico inhibitor Interaction isolate Lopinavir metabolite metabolites Micrococcus morphologically nine NMR nucleotide nucleotide sequence outcome performed phytohormone plant profiles protease protein-protein network protein-protein networks protocol Pseudomonas species rDNA reported Research Sanger sequencing Secondary Metabolite sequence similarity Staphylococcus structures submission target protein target proteins tested these compounds was performed were assessed [DOI] 10.1371/journal.pone.0269962 PMC 바로가기 [Article Type] Article