Effects of Interrupting Prolonged Sitting with Light-Intensity Physical Activity on Inflammatory and Cardiometabolic Risk Markers in Young Adults with Overweight and Obesity: Secondary Outcome Analyses of the SED-ACT Randomized Controlled Crossover TrialArticle Published on 2024-08-192024-09-05 Journal: Biomolecules [Category] update2024, [키워드] Cardiometabolic risk light-intensity physical activity snacks low-grade inflammation obesity overweight Sedentary behavior young adults [DOI] 10.3390/biom14081029 PMC 바로가기 [Article Type] Article
Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem InvolvementReview Published on 2024-06-092024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] chronic inflammation Diagnostic strategies Inflamm-aging Long COVID low-grade inflammation PASC pathophysiology Personalized medicine Post COVID-19 condition systemic inflammation [DOI] 10.3390/ijms25126389 PMC 바로가기 [Article Type] Review
The potential of short-chain fatty acid epigenetic regulation in chronic low-grade inflammation and obesityImmunology Review Published on 2024-03-272024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] epigenetics lipopolysaccharide low-grade inflammation obesity short-chain fatty acids [DOI] 10.3389/fimmu.2024.1380476 PMC 바로가기 [Article Type] Immunology Review
Repurposing SGLT-2 Inhibitors to Target Aging: Available Evidence and Molecular MechanismsArticle Published on 2022-10-142022-11-15 Journal: International Journal of Molecular Sciences [Category] 신약개발, 진단, [키워드] accompanied activity addition aging all-cause mortality animal model animal models available data benefit Biomarker blunt caloric restriction calories cardiovascular diseases Cardiovascular outcomes cellular senescence clinical study clinical trials Compound COVID-19 decrease diabetes driver drug drugs employment Evidence Fatty acid feature Glucose heart failure humans IL-6 independent inflammaging Inflammasome inhibitor inhibitors intrinsic Kidney disease low-grade inflammation Meta-analysis modulating modulation molecular Mortality nutrient-sensing pathways observational studies outcomes pathway Patient promote provided repurposing selected senescence sodium-glucose cotransporter 2 inhibitors. substrates suggested Support systemic effects systemic level target Urine [DOI] 10.3390/ijms232012325 PMC 바로가기
Vaccination in patients with kidney failure: lessons from COVID-19 Reviews Published on 2022-08-012022-10-05 Journal: Nature reviews. Nephrology [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Adequate antibody cause cellular Chronic kidney disease CKD comparable COVID-19 COVID-19 vaccine death detectable detrimental effect dialysis Diseases dose generate humoral Humoral immunity immune immune system Immunity infection control kidney Kidney function kidney transplant recipient life-threatening low-grade inflammation pathogen pathogen clearance Patient patients Prevent promote receiving regimens required SARS-CoV-2 SARS-COV-2 infection seroconversion rate severe COVID-19 T cell response vaccination vaccination efficacy [DOI] 10.1038/s41581-022-00617-5 [Article Type] Reviews
Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional studyPost-COVID-19 증후군, 저등급 염증 및 염증 표지자: 단면 연구Article Published on 2022-06-012022-09-11 Journal: Current medical research and opinion [Category] MERS, 바이오마커, [키워드] acute COVID-19 acute phase affected age Ageusia analysed Analysis Anosmia association available data best Biomarker Biomarkers BMI C-reactive protein collected Community community setting Comorbidities correlation COVID-19 COVID-19 case cross-sectional cross-sectional study CRP D-dimer level D-dimer levels defined develop distributions Dyspnea Elevation epidemiological data fatigue ferritin fibrinogen Fibrinogen levels Frequency highest identify increased risk Infection Inflammatory inflammatory markers Laboratory Laboratory test Lactate lactate dehydrogenase low-grade inflammation lymphocyte lymphocyte counts marker men Mild mild COVID-19. multivariable analysis multivariate multivariate analyses myalgia neutrophil neutrophil count neutrophil counts neutrophil/lymphocyte ratio NLR pathophysiological mechanism performed post-COVID syndrome prevalent reported symptom selected serum C-reactive protein Sex Sex difference Signs and symptoms smoking subject Symptom Symptoms syndrome the median variable with COVID-19 woman women [DOI] 10.1080/03007995.2022.2042991 PMC 바로가기 [Article Type] Article
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations심각한 COVID-19 3개월 후 호흡기 기능 장애는 장내 미생물 변화와 관련이 있습니다Article Published on 2022-06-012022-09-11 Journal: Journal of internal medicine [Category] COVID19(2023년), SARS, 임상, [키워드] 16S rRNA 16S rRNA gene alteration Analysis analyzed Bacterial carbon monoxide collected coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 patient defined diffusing diffusing capacity disease severity dysfunction elevated Evidence fibrosis FIVE Follow-up gastrointestinal tract Gut gut microbiota gut microbiota composition gut-lung axis Hospital admission Hospitalization Hypothesis Inflammation investigated involved kPa LBP limit lipopolysaccharide low-grade inflammation lung Lungs marker Microbiome microbiota P/F ratio Patient plasma Protein pulmonary dysfunction Pulmonary function Rectal swabs reduced remained respiratory Respiratory failure respiratory infection rRNA SARS-CoV-2 Sequencing severe COVID-19 Swab the disease Trial was collected was reduced [DOI] 10.1111/joim.13458 PMC 바로가기 [Article Type] Article
CD8 + T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and CancerCD8 + T 세포 노화: 바이러스 감염, 자가면역 장애 및 암의 빛과 그림자Review Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, 바이오마커, [키워드] Adaptive immune response addition Ageing Antigen Autoimmune Autoimmune disease Autoimmune diseases autoimmune disorder Autoimmune disorders Cancer cause caused CD28 CD28− CD57+ CD8+ T cells CD57 CD8 CD8+ Cell circulating clearance CMV condition contributing to cytotoxic function Diseases Effect Efficacy enrichment exacerbate favor function functions heterogeneous HIV immune-senescence immunological immunotherapies Immunotherapy implication IMPROVE Infection inflammaging inflammaging. life LIGHT low-grade inflammation lowering Lymphocytes memory Memory cells novel antigen novel antigens pathogen Pathogens phenotype Prevent progression reduction SARS-CoV-2 senescent shadow Stress switching T cell T cells T lymphocyte T lymphocytes the disease thymic Transformed cell transformed cells Tumor tumor microenvironment turn Vaccine vaccine efficacy Viral viral infection viral infections [DOI] 10.3390/ijms23063374 PMC 바로가기 [Article Type] Review
Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials고령자의 C 반응성 단백질 및 염증성 사이토카인에 대한 저항 훈련의 효과: 무작위 대조 시험의 체계적인 검토 및 메타 분석Review Published on 2022-03-142022-09-11 Journal: International Journal of Environmental Research an [Category] MERS, 바이오마커, 임상, [키워드] 95% confidence interval accompany Adults age aging Analysis C-reactive protein can be used chronic Chronic low-grade inflammation CINAHL Cochrane Library Controlled COVID-19 CRP Cytokines Effect effect size effective elderly evaluated Evidence exacerbate fixed Frequency Health Health status IL-10 IL-6 IMPROVE Inconclusive Infectious disease Inflammation intensity interleukin low-grade inflammation Necrosis outcome patients Random-effects models Randomized controlled trial reduce reduction resistance Resistance training review searched severity Subgroup analyses subgroup analysis The effect size TNF-α training Tumor tumor necrosis tumor necrosis factor was performed [DOI] 10.3390/ijerph19063434 PMC 바로가기 [Article Type] Review
Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전Review Published on 2022-03-032022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection [DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review