Enrichment analysis on regulatory subspaces: A novel direction for the superior description of cellular responses to SARS-CoV-2규제 부분 공간에 대한 농축 분석: SARS-CoV-2에 대한 세포 반응의 우수한 설명을 위한 새로운 방향Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자, [키워드] affected Algorithm Analysis applied Biclustering Cell cell line cellular response Characteristics classic Clustering Comparative analysis complex Computational biology Coverage COVID-19 database Discriminative regulatory patterns enrichment enrichment analysis False positive functional enrichment Functional enrichment analysis GO term GO terms H1N1 IAV identify Impact IMPROVE in vivo infected cell infected cells Interaction KEGG pathway knowledge knowledge extraction lack lung cell line lung cell lines machine machine learning machine learning algorithm machine learning approach motivation observations pathophysiological performed Predictive Regulatory RSV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus scarcity significantly the SARS-CoV-2 virus transcriptional response transcriptomic data transcriptomics variant virus viruses [DOI] 10.1016/j.compbiomed.2022.105443 PMC 바로가기 [Article Type] Article
Effective Reduction of SARS-CoV-2 RNA Levels Using a Tailor-Made Oligonucleotide-Based RNA Inhibitor맞춤형 올리고뉴클레오티드 기반 RNA 억제제를 사용한 SARS-CoV-2 RNA 수준의 효과적인 감소Article Published on 2022-03-252022-09-11 Journal: Viruses [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral agents caused cellular coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Efficiency inhibitor lack Level lung cell lines management oligonucleotide oligonucleotide-based RNA inhibitor. pandemic patients hospitalized priority public health RdRP reducing RNA RNA levels RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus therapeutic with COVID-19 [DOI] 10.3390/v14040685 PMC 바로가기 [Article Type] Article
AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity항섬유증 miRNA 유사 활성을 가진 SARS-CoV-2를 표적으로 하는 강력한 siRNA 서열의 AGO CLIP 기반 전가Article Published on 2021-09-272022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] (RdRp acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antifibrotic Argonaute binding calculate caused conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 crosslinking fibrosis immunoprecipitation induce Local lung cell line lung cell lines microRNA MicroRNAs miRNA miRNAs non-structural protein Nsp12 parameter predict pulmonary fibrosis RdRP repressed respiratory RNA RNA interference RNA viruses RNA-dependent RNA polymerase RNAi therapy SARS-CoV-2 SARS-CoV-2 genome screened seed sequence Sequence annotation Sequencing severe acute respiratory syndrome Coronavirus siRNA siRNAs Small interfering RNA small interfering RNAs susceptible synthesised TGF-β the SARS-CoV-2 genome transcript Transcriptome transcriptomes treat utilised variants [DOI] 10.1038/s41598-021-98708-z PMC 바로가기 [Article Type] Article
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice마우스에서 SARS-CoV-2 발병에 대한 렘데시비르의 경구 뉴클레오시드 유사체의 치료 효능Article Published on 2021-09-172022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] administration Antiviral antiviral activity antivirals Breakthrough infection breakthrough infections breath conserved COVID-19 COVID-19 pandemic Culture develop dose-dependent drug effective Efficacy exhibited exploration GS-441524 human clinical trial humans IMPROVE in vitro in vivo increasingly infected with SARS-CoV-2 Infection lung cell lung cell line lung cell lines Lung pathology mice molnupiravir monoclonal antibodies monoclonal antibody nucleoside oral administration outcome outpatients parental pharmacokinetic Pulmonary function reduced Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly Support target therapeutic therapeutic efficacy therapy These data translated Treatment uncontrolled vaccination Viral load Viral protein Viral proteins waning immunity [DOI] 10.1101/2021.09.13.460111 PMC 바로가기 [Article Type] Article
COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?Review Published on 2021-03-192022-10-30 Journal: Nanomaterials [Category] COVID-19, [키워드] acute respiratory syndrome administration Antiviral assessments BNT162b2 cell entry Containment strategy coronavirus COVID-19 embryos Express facemasks highlight Human human–animal interfaces humans Impact in vitro in vivo information lung cell lines lung cells manuscript mRNA-1273 vaccines Nanoparticles Nanotoxicology Neurological symptoms new SARS-CoV-2 olfactory parameter performed Protein recent findings reported Safe Safety SARS-CoV-2 skeptical opinion supported the SARS-CoV-2 Toxicity vaccination variants zebrafish [DOI] 10.3390/nano11030796 PMC 바로가기 [Article Type] Review
Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection네트워크 분석 및 전사체 프로파일링으로 SARS-CoV-2 감염에서 자가포식 및 미토콘드리아 기능 장애 식별Genetics Published on 2021-03-162022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] A549 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral antiviral signaling autophagic autophagic flux autophagy autophagy genes biological processe biological processes Calu3 chemokines co-expression network analysis contributing to coronavirus COVID-19 Critical downregulated downregulating drugs targeting expression of gene expression profile expression profiles GSK3B help host cell host cells IAV infected cell infected cells Infection infections Inflammation Inflammatory Influenza influenza A influenza A virus interferon signaling interferon-stimulated genes Intervention involved lung cell line lung cell lines lysosome acidification MERS MERS-CoV mitochondrial mitochondrial complex I mitochondrial fission Mitochondrial function mitochondrial ribosomal mTOR mTOR expression nasopharyngeal sample network Perturbation perturbations Profiling respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SNAP29 tested transcriptional response transcriptomics Tripartite Motif upregulating upregulation validation study Viral viral pathogenesis viral replication [DOI] 10.3389/fgene.2021.599261 PMC 바로가기 [Article Type] Genetics
The Role of Viral Population Diversity in Adaptation of Bovine Coronavirus to New Host EnvironmentsResearch Article Published on 2013-01-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adaptation amplified arginine residues average coverage binding bovine Bovine coronavirus cell type coded consensus sequence coronavirus Coronaviruses de novo mutation deep deep sequencing different Diversity Environment events fixation Frequency Genetic genetic diversity Genome genomic change Genotype high mutation rate Host host cells Hypothesis indicated infect Infected Infection lung cell line lung cell lines Macrophage macrophages Multiple Mutation Nasal sample New nucleotide occurred Pathogens Point mutation Population quasispecy respond RNA virus role selective pressure sequenced Sequencing spike gene strain subsequent Support virus was used were used [DOI] 10.1371/journal.pone.0052752 PMC 바로가기 [Article Type] Research Article