SARS-CoV-2 infection alters mitochondrial and cytoskeletal function in human respiratory epithelial cells mediated by expression of spike proteinarticle Published on 2023-07-282024-09-05 Journal: mBio [Category] update2024, [키워드] Actin bioenergetics COVID-19 cytoskeleton lung epithelia SARS-CoV-2 [DOI] 10.1128/mbio.00820-23 PMC 바로가기 [Article Type] article
Wnt-Independent SARS-CoV-2 Infection in Pulmonary Epithelial Cellsarticle Published on 2023-06-272024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] Clofazimine Drug discovery lung epithelia SARS-CoV-2 Wnt Wnt pathway inhibitors Wnt signaling [DOI] 10.1128/spectrum.04827-22 PMC 바로가기 [Article Type] article
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 modelArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Activation animal model antiviral property ciliated cells COVID-19 disease epithelial Factor FG-4592 Host hypoxia hypoxic identify increased expression Infection Infectious virus inhibit SARS-CoV-2 inhibitor intrinsic Lower respiratory tract lung epithelia microenvironment nucleocapsid expression pathological analysis pathway provide reduced reduction in regulate respiratory pathogen respiratory symptom SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA significantly susceptibility therapeutic Therapies transcriptional treated understanding virus replication [DOI] 10.1371/journal.ppat.1010807 PMC 바로가기
Roles of steroid receptors in the lung and COVID-19Endocrinology Published on 2021-11-262022-10-31 Journal: Essays in Biochemistry [Category] COVID-19, SARS, [키워드] ACE2 androgen angiotensin-converting enzyme 2 caused clinical trial coronavirus COVID-19 COVID-19 symptom disease Effect Estrogens expression facilitate glucocorticoid hormone receptor host cell immune system Infection knowledge Ligand lung lung epithelia Lungs Mortality Nuclear receptors progesterone Protein provide receptor respiratory role SARS-CoV-2 Steroids TMPRSS2 transmembrane serine protease treat [DOI] 10.1042/EBC20210005 PMC 바로가기 [Article Type] Endocrinology
COVID-19: Lung-Centric ImmunothrombosisCellular and Infection Microbiology Published on 2021-06-112022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] activated Activation acute respiratory distress acute respiratory distress syndrome (ARDS) antimicrobial ARDS blood vessel Coagulation factors coronavirus COVID-19 COVID-19 patients cytokine production Cytokine storm cytoplasmic death Evidence favor immunothrombosis Infection innate immune response Local lung epithelia Macrophage microbes NET NETs neutrophil Neutrophil extracellular trap Neutrophils Platelet Pulmonary infection recruitment respiratory tract SARS-CoV-2 syndrome Therapeutic approach virus while [DOI] 10.3389/fcimb.2021.679878 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids줄기 세포 기술 및 오르가노이드를 사용한 SARS-CoV-2 감염 및 질병 모델링Review Published on 2021-02-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 airway epithelial cells alveolar Apoptosis cardiovascular system Cell cell damage cells Central nervous system Choroid plexus Clinical studies clinical study colonic contribute demonstrated Direct disease Endothelial cell endothelial cells Enterocyte enterocytes epithelial epithelial cells gastrointestinal tract highlighting human host Hypothesis immunological impairing in vitro model indirect effect indirect effects infect infected individuals Inflammation innate immune response intestinal organoid lung lung alveolar lung epithelia mechanism Neurological symptom Neurological symptoms Neuron neurons Organoid organoids organs Pathogenesis pathogenesis of SARS-CoV-2 replicate review SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 pathogenesis STEM stem cell surfactant susceptible systemic inflammatory target technology Trigger triggers tropism type I variance Vascular damage Viral viral damage viral infection virus [DOI] 10.3390/ijms22052356 PMC 바로가기 [Article Type] Review
Effect of ambient temperature on respiratory tract cells exposed to SARS-CoV-2 viral mimicking nanospheres-An experimental studySARS-CoV-2 바이러스 모방 나노스피어에 노출된 호흡기 세포에 대한 주변 온도의 영향-실험 연구Article Published on 2021-01-282022-09-12 Journal: Biointerphases [Category] 진단, [키워드] ACE-2 ACE-2 receptor acute respiratory syndrome airway epithelial cell ambient angiotensin-converting enzyme 2 binding bovine Calu-3 caused change coated with Community coronavirus country denaturing Effect fibroblast cell fluctuation had no Host host cell incubated indicated infect Infection Infectious disease Interaction lung epithelia mimicking modulated nonspecific Novel coronavirus occurred pandemic Polymer Protein RBD reached reported respiratory tract respiratory tract cell S protein S-RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral seasonal serum Spread stability surface receptor temperature the S protein the SARS-CoV-2 Transmission Viral transmission virus [DOI] 10.1116/6.0000743 PMC 바로가기 [Article Type] Article
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic OpportunitiesPharmacology Published on 2020-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute lung injury ADA adenosine adenosine deaminase adenosine kinase ADK binding caused CD26 coronavirus COVID COVID-19 COVID-19 pathogenesis develop highlight IMPROVE Infection lung epithelia Lung injury novel coronavirus disease opportunity outbreak outcomes platelet activation receptor reduce respiratory role SARS-CoV-2 SARS-COV-2 infection Spread the disease therapeutic use thrombosis virus [DOI] 10.3389/fphar.2020.594487 PMC 바로가기 [Article Type] Pharmacology
Prediction and Analysis of SARS-CoV-2-Targeting MicroRNA in Human Lung EpitheliumCommunication Published on 2020-08-262022-10-31 Journal: Genes [Category] COVID-19, [키워드] acute respiratory syndrome binding site cellular cellular antiviral defence coronavirus coronavirus disease Coronavirus infection COVID-19 differentially expressed epithelium Evidence expression expression profile Genome Human identify In vitro infection Infection infections low expression lung epithelia lung epithelial mechanism MERS-CoV genome microRNA pandemic pathogenic coronavirus predicted prediction PROTECT Research responsible RNA virus RNA viruses SARS-CoV SARS-CoV-2 susceptibility the SARS-CoV-2 genome tissue viral propagation [DOI] 10.3390/genes11091002 PMC 바로가기 [Article Type] Communication