A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory responseBiological Sciences Cell Biology Published on 2024-07-192024-09-05 Journal: Proceedings of the National Academy of Sciences of [Category] update2024, [키워드] COVID-19 Inflammation lung organoids macropinocytosis surfactant [DOI] 10.1073/pnas.2408109121 PMC 바로가기 [Article Type] Biological Sciences Cell Biology
Organotypic human lung bud microarrays identify BMP-dependent SARS-CoV-2 infection in lung cellsarticle Published on 2023-04-202024-09-05 Journal: Stem Cell Reports [Category] update2024, [키워드] BMP signaling COVID-19 Endemic coronaviruses fetal lung lung buds lung development lung differentiation lung organoids micropatterned hESCs SARS-CoV-2 [DOI] 10.1016/j.stemcr.2023.03.015 PMC 바로가기 [Article Type] article
Organoid technology and lung injury mouse models evaluating effects of hydroxychloroquine on lung epithelial regenerationArticle Published on 2022-08-052023-07-08 Journal: Experimental animals [Category] COVID19(2023년), [키워드] alveolar type 2 (AT2) cells Club cells epithelial regeneration lung organoids mouse model [DOI] 10.1538/expanim.21-0168 PMC 바로가기
Synergistic Interferon-Alpha-Based Combinations for Treatment of SARS-CoV-2 and Other Viral InfectionsArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect Analysis Antiviral antiviral drug combination antiviral property Calu-3 cell changes in clinical development Combination concentrations convalescent serum coronavirus cycloheximide demonstrated drug effective EIDD-2801 HCV hepatitis C virus hepatitis E virus HIV homeostasis Human immunodeficiency virus IFN IFNs IFNα in vitro indicated influenza A virus interferon interferon-alpha lung organoids metabolomic NITD008 organoids Other protein synthesis Remdesivir Replication ribavirin SARS-CoV-2 Side effects suppressed synergistic target tested therapeutic potential tolerable Transcription uninfected cell viral infections Viral RNA while [DOI] 10.3390/v13122489 PMC 바로가기 [Article Type] Article
Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry데이터 기반 접근 방식과 SARS-CoV-2 진입의 폐 오르가노이드 모델을 사용하여 COVID-19에 대한 다중 모드 특성을 가진 FDA 승인 약물 식별Research Article Published on 2021-09-092022-09-10 Journal: Molecular Medicine [Category] SARS, 신약개발, 치료제, [키워드] analyses approach atorvastatin chemoinformatics Clinical studies clinical study combined treatment Compound Connectivity mapping correlated COVID-19 data-driven database docking drug drug repositioning Drug screening Drug testing Effect FDA-approved drug FDA-approved drugs identify identifying individual Infection inhibit less lung lung organoids molecular docking pandemic Pandemics predicted Prophylactic protease protective effect Protective effects reported Result RNA-dependent RNA polymerase Safe SARS-CoV-2 entry shown spread of COVID-19 statin supplementary material transcriptional change Transcriptional changes transcriptomic vaccine availability Viral viral entry with infection [DOI] 10.1186/s10020-021-00356-6 PMC 바로가기 [Article Type] Research Article
Advancing lung organoids for COVID-19 researchOrganoids Published on 2021-06-012022-10-31 Journal: Disease Models & Mechanisms [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Advancing Antiviral Cell cellular collaboration coronavirus COVID-19 pandemic COVID-19 research develop effective lung organoid lung organoids Model model system pandemic pulmonary Research resources SARS-CoV-2 SARS-CoV-2 pathogenesis Treatment virus viruses [DOI] 10.1242/dmm.049060 PMC 바로가기 [Article Type] Organoids
Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19Medicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] in vitro lung models acute respiratory distress affected alveolar alveolar epithelium alveolar regeneration ARDS assumed cause caused causing classical clinically collagen coronavirus coronavirus disease COVID-19 current DAD Diffuse alveolar damage disease ECM Effect Evidence Extracellular matrix fatal disease fibroblast in vitro in vitro model in vivo induce interstitial interstitial pulmonary fibrosis IPF knowledge lung Lung diseases Lung fibrosis lung organoids lung-on-chip mechanical stress molecular mechanism multicellular organoids Oxygenation pandemic Pathogenesis pathophysiological patients precision-cut lung slices proliferation Proteins pulmonary pulmonary fibrosis pulmonary impairment Pulmonary infection reduced respiratory SARS-CoV-2 SARS-COV-2 infection Symptoms syndrome tissue tissue regeneration treatment strategy Vaccine viral infections wound healing [DOI] 10.3389/fmed.2021.644678 PMC 바로가기 [Article Type] Medicine
SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental ModelsPharmacology Published on 2021-04-222022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray [DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19Article Published on 2021-04-092022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome calu-3 cells clinical clinical isolate Combination compounds Confirmed coronavirus coronavirus disease Corticosteroid COVID-19 demonstrated drug drug combinations Drug repurposing effective drugs eight FDA-approved drug FDA-approved drugs food greater high-content screening identify illnesses in vitro infections isolate Korean late stage lung organoids medical need MERS-CoV Middle East Middle East respiratory syndrome Coronavirus option pandemic Potential Remdesivir representing respiratory syndrome coronavirus SARS-CoV-2 screened Screening selected drug severe acute respiratory syndrome coronavirus disease South South Korea tested therapeutic therapeutic option treat United State VERO-E6 viral life cycle [DOI] 10.3390/v13040651 PMC 바로가기 [Article Type] Article
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infectionSARS-CoV-2 감염 시 인간의 기도 및 폐포 오르가노이드에서 숙주 대사 조절 장애 및 세포 친화성 식별Research Article Published on 2020-12-122022-09-10 Journal: Protein & Cell [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition airway alveolar animals AT2 Cancer cells caused Cell cell line cell lines cell tropism cells cellular metabolism ciliated club Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture distal downregulation Drug discovery dysregulation embryonic embryonic stem cells human airway human lung organoid human lung organoids humans immune response in vitro infect infected cell infected cells Infection inhibited lipid metabolism lung organoids Lungs mechanism metabolic processes metabolism neutralizing antibody Organoid organoids organs pandemic pathophysiological physiological condition physiological conditions proximal Remdesivir replicated respiratory respiratory droplet Respiratory droplets RNA-Seq route SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Spread stem cell supplementary material therapeutic drug upregulation virus infection [DOI] 10.1007/s13238-020-00811-w PMC 바로가기 [Article Type] Research Article