Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLproEnzymology Published on 2024-08-282024-09-05 Journal: Bioscience Reports [Category] update2024, [키워드] 3CLpro antivirals flavonoids Luteolin micronutrients SARS-CoV-2 [DOI] 10.1042/BSR20240617 PMC 바로가기 [Article Type] Enzymology
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophagesResearch Published on 2024-03-182024-09-05 Journal: Chinese Medicine [Category] update2024, [키워드] co-culture combination therapy HBV Liuwei Wuling Tablets Luteolin Schisandrin C [DOI] 10.1186/s13020-024-00888-z PMC 바로가기 [Article Type] Research
Humulus japonicus ameliorates irritant contact dermatitis by suppressing NF‑κB p65‑dependent inflammatory responses in miceArticle Published on 2023-09-022024-09-05 Journal: Experimental and Therapeutic Medicine [Category] update2024, [키워드] 12-O-tetradecanoylphorbol-13-acetate Humulus japonicus Irritant contact dermatitis Luteolin NF-κB p65 [DOI] 10.3892/etm.2023.12145 PMC 바로가기 [Article Type] Article
Effect of Ultra-Micronized Palmitoylethanolamide and Luteolin on Olfaction and Memory in Patients with Long COVID: Results of a Longitudinal StudyRandomized Controlled Trial Published on 2022-08-172022-10-05 Journal: Cells [Category] 임상, [키워드] absence affected age ameliorated Anosmia average baseline Biomarkers Brain brain fog Combination COVID COVID-19 disorders Effect group Hyposmia interval investigated Long long-haul COVID syndrome longitudinal lutein Luteolin measure mechanisms memory men Mental mental clouding Neuroinflammation Olfaction olfactory olfactory dysfunction olfactory threshold olfactory training outcomes palmitoylethanolamide parosmia Patient patients PEA-LUT Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence qualitative smell disorders Quantitative Randomized receive recruited reduction in regimen remaining group Result SARS-COV-2 infection self-report measure severity smell disorders. subjects subsequent therapy thresholds Treatment were assessed women [DOI] 10.3390/cells11162552 PMC 바로가기 [Article Type] Randomized Controlled Trial
Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones상업적으로 이용 가능한 플라보놀은 이소플라본 및 플라본보다 더 나은 SARS-CoV-2 억제제입니다Article Published on 2022-06-302022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] 50% effective concentration acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-SARS-CoV-2 apigenin Atazanavir Better Calu Calu-3 calu-3 cells circulating class comparable Compound coronavirus COVID-19 COVID-19 treatment different disease different diseases drugs evaluate ExoN exonuclease Fisetin flavone flavones flavonoids flavonol flavonols fruits Genistein humoral immune response hydroxyl hydroxyl group hydroxyl groups IMPROVE in silico inhibit SARS-CoV-2 inhibiting inhibitor isoflavone kaempferol Luteolin M pro Modification molecular molecular docking myricetin natural product Orientation potency protease quercetin SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus target TNF-α Treatment Vaccines variants variants of concern [DOI] 10.3390/v14071458 PMC 바로가기 [Article Type] Article
Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase Research Published on 2022-06-222022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] activities acute respiratory syndrome ancestor binding mode Compound coronavirus cryo-EM structure docking enzyme Health IC50 inhibit inhibitor Intervention Luteolin pandemic pharmacological quercetin RdRP RdRp inhibitor responsible returned RNA-dependent RNA polymerase SARS-CoV-2 starting point target tested the SARS-CoV-2 these compound These data treat variety viral genome replication viral infections Viral proteins [DOI] 10.1038/s41598-022-14664-2 [Article Type] Research
Chemical profiling and unraveling of anti-COVID-19 biomarkers of red sage (Lantana camara L.) cultivars using UPLC-MS/MS coupled to chemometric analysis, in vitro study and molecular docking화학 측정 분석, 시험관 내 연구 및 분자 도킹과 결합된 UPLC-MS/MS를 사용하여 레드 세이지(Lantana camara L.) 품종의 항-COVID-19 바이오마커의 화학적 프로파일링 및 해명Article Published on 2022-06-122022-09-11 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis anti-COVID-19 activity. antiviral activity approach Asia Biomarker Biomarkers Brazil Candidates Chain Reaction Chemical chemometrics Compound Concentration coronavirus COVID-19 cytotoxicity Data analysis detect determine docked docking docking score E-gene Effect Efficacy except for exhibited exhibiting expression expression levels flavonoids flower followed by highest in vitro study In-vitro India infections inhibitor inhibitory activity interaction pattern Kenya Lantana Lantana camara L. cultivars leprosy Luteolin material mechanism metabolites metabolomics molecular docking multivariate Multivariate analysis Nigeria PCA PCA plot PCA plots plaque polymerase chain polymerase chain reaction principle profile progressed RdRP RdRp gene real-time RT-PCR Red Remdesivir required respiratory respiratory diseases respiratory virus respiratory viruses reverse transcription polymerase chain reaction rheumatism RNA-dependent RNA polymerase RT-PCR SARS-CoV-2 selectivity indices severe acute respiratory syndrome Coronavirus Spread spreading Structure sunset TaqMan target tested Transcription UPLC UPLC-MS/MS Verbenaceae Viral [DOI] 10.1016/j.jep.2022.115038 PMC 바로가기 [Article Type] Article
Can nutraceuticals assist treatment and improve covid-19 symptoms?Article Published on 2022-05-012022-10-05 Journal: Natural Product Research [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] antiviral drug assist astaxanthin Can clinical picture conducted coronavirus COVID-19 COVID-19 patient Curcumin disease Elderberry glycyrrhizin Health hesperidin IMPROVE Infection lactoferrin Luteolin Numerous nutraceutical nutraceuticals pandemic Prevent quercetin SARS-CoV-2 SARS-CoV-2 vaccines shown Symptom syndrome therapy Treatment [DOI] 10.1080/14786419.2021.1914032 [Article Type] Article
Systems pharmacology-based drug discovery and active mechanism of natural products for coronavirus pneumonia (COVID-19): An example using flavonoidsResearch article Published on 2022-04-012022-10-05 Journal: Computers in biology and medicine [Category] 치료제, [키워드] 3CL ABC Analysis Anti-inflammatory Antiviral antiviral effects Combination complex component Compound Coronavirus pneumonia COVID-19 demonstrated drug Drug discovery Drug screening EGCG EGFR Epigallocatechin-3-gallate example flavonoids functions immune responses Inflammatory KEGG KEGG pathway Kyoto Luteolin mechanism mechanism of action mechanisms molecular docking natural natural products NOS Ontology pathway enrichment pharmacological PPI Prevent Pro Protein protein-protein interaction quercetin resource Result second selected selective stability System Systems pharmacology target targets tissue injury treat Treatment was performed [DOI] 10.1016/j.compbiomed.2022.105241 [Article Type] Research article
Different compounds against Angiotensin-Converting Enzyme 2 (ACE2) receptor potentially containing the infectivity of SARS-CoV-2: an in silico studyOriginal Paper Published on 2022-03-052023-06-15 Journal: Journal of molecular modeling [Category] MERS, SARS, [키워드] angiotensin-converting enzyme 2 chrysin Luteolin Molecular Docking Simulation Molecular dynamics simulation SARS-CoV-2 Spike protein [DOI] 10.1007/s00894-022-05059-1 PMC 바로가기 [Article Type] Original Paper