The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemicReview Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] Apoptosis Caspases Cathepsins cell death COVID-19 Lysosomes Proteases pyroptosis SARS-CoV-2. [DOI] 10.1007/s43440-022-00394-9 PMC 바로가기 [Article Type] Review
Modulating Fingolimod (FTY720) Anti-SARS-CoV-2 Activity Using a PLGA-Based Drug Delivery SystemArticle Published on 2022-07-182022-10-04 Journal: ACS applied bio materials [Category] COVID19(2023년), SARS, 신약개발, [키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activity cell line Combination concentrations confocal microscopy COVID-19 COVID-19 case Cytometry death delivery develop Disease progression drug Drug repurposing encapsulation exhibit fingolimod Flow FTY720 less Lysosomes macropinocytosis nanoparticle Nanotechnology. occur pathway PLGA PLGA-based nanoparticles reduce Safe System therapy for COVID-19 Toxicity Treatment Vaccine viral infection Viral transmission [DOI] 10.1021/acsabm.2c00349 PMC 바로가기 [Article Type] Article
Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway리소좀 기반 경로에 대한 SARS-CoV-2 복제의 의존성을 악용하는 잠재적인 항바이러스 전략Review Published on 2022-05-312022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anti-SARS-CoV-2 correlation country COVID-19 CTSL CTSL activities dependence disease drug effective eukaryotic cells exit experimental evidence lack life cycle lysosomal lysosomal acidification lysosomal function. Lysosomes moderate Novel coronavirus outbreak pathway Potential public health regions Replication required SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 replication SARS-CoV-2 variant severe COVID-19 patients shown Strategy Support the SARS-CoV-2 Treatment variant virus entry [DOI] 10.3390/ijms23116188 PMC 바로가기 [Article Type] Review
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review
MERS-CoV nsp1 impairs the cellular metabolic processes by selectively downregulating mRNAs in a novel granulesResearch Article Published on 2022-02-062022-10-28 Journal: Virulence [Category] COVID-19, [키워드] Act Actinomycin Analysis Antigen presentation Cell Cell migration cells cellular complex death downregulated downregulating explain Genes Granule impair Inflammatory inhibit LLPS Lysosomes mass spectrometry mechanism MERS-CoV MERS-CoV infection metabolic processe metabolic processes Middle East mRNA non-structural protein nsp1 oxidative phosphorylation P-bodies Protein Regulatory respiratory syndrome coronavirus ribosomal protein ribosome RNA sensitivity Sequencing shown stress granule stress granules transcriptional transgenic mice upregulated viability [DOI] 10.1080/21505594.2022.2032928 PMC 바로가기 [Article Type] Research Article
GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy InhibitionGNS561은자가 포식 억제를 통한 SARS-COV-2에 대한 강력한 항 바이러스 활성을 나타낸다.Article Published on 2022-01-122022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] accumulation activity antiviral activity autophagic autophagy blocker caused Chloroquine Compound confirmed cases coronavirus COVID-19 deaths Disruption exhibited Ezurpimtrostat GNS561 GNS561/Ezurpimtrostat hACE2 highlight Hypothesis inhibition inhibitor investigated K18-hACE2 LAMP2 LC3 lung Lungs lysosome Lysosomes mechanism pathway potent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virion SARS-CoV-2 virions Spread Support Treatment Viral viral replication viral strain [DOI] 10.3390/v14010132 PMC 바로가기 [Article Type] Article
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophagesACE2 발현 미립자에 의한 SARS-CoV-2 치료 효과는 폐포 대식세포의 산화된 콜레스테롤 증가 엔도솜 pH로 설명Article Published on 2022-01-042022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] A549 addition Administered alveolar macrophage Alveolar macrophages anatomical cell-derived microparticle cholesterol cross-talk decrease Degradation Effect Efficacy emerging respiratory virus Endosomal acidification endosomal pH Endosomes explained feasibility feature highlight immune system impairing inhibit lung lysosomal lysosome Lysosomes membranes Microparticle microparticles oxidized phenotype proinflammatory Regulation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 treatment SARS-CoV-2-infected patient Side effects therapeutic therapy translocated treat Treatment viral infection [DOI] 10.1038/s41423-021-00813-6 PMC 바로가기 [Article Type] Article
Cultivation of Cells in a Physiological Plasmax Medium Increases Mitochondrial Respiratory Capacity and Reduces Replication Levels of RNA VirusesArticle Published on 2021-12-302022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] blood plasma Cancer Capacity Cell change concerning coronavirus cultivation culture medium cultured cells dysregulated ENhance event Glycolysis HCV hepatitis C virus Human plasma IAV identification increase Inflammatory diseases influenza A virus Influenza virus Intervention less Level lysosome Lysosomes mammalian cell media medium metabolic pathway metabolism metabolite mitochondrial mitochondrial network obesity pathology performed Plasmax reactive oxygen species reactive oxygen specy Replication Respiration respiratory RNA RNA viruses ROS SARS-CoV-2 serine biosynthesis significantly standard media Support syndrome two group viral infections were used [DOI] 10.3390/antiox11010097 PMC 바로가기 [Article Type] Article
The utilization of hydroxychloroquine to reduce the main signs and symptoms of COVID-19 patients, a cross-sectional studyCase-controlled Study Published on 2021-09-162022-10-04 Journal: Annals of Medicine and Surgery [Category] 신약개발, 치료제, [키워드] accumulate Acidic alkaline all subject analyzed Area Area under the curve (AUC) Arm Asymptomatic COVID-19 AUC benefit body temperature breath cell membranes cells Chloroquine clinical trial Concentration coronavirus cough COVID-19 COVID-19 patient COVID-19 positive patient cross-sectional Diagnosis effective Efficacy evaluate Fever Follow-up function HCQ Hydroxychloroquine inclusion criteria increase Infection Loading dose lysosome Lysosomes maintenance dose no significant effect non-randomized objective Open-label participant Patient patients penetrate positive positive result presenting Prevent receive reduce reducing Result severe disease Shortness of breath statistically subject Symptom symptomatic symptoms of COVID-19 Trial two groups utilization variable Viral load were used while [DOI] 10.1016/j.amsu.2021.102867 PMC 바로가기 [Article Type] Case-controlled Study
Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individualsArticle Published on 2021-08-282022-11-01 Journal: Science Immunology [Category] COVID-19, MERS, SARS, [키워드] activated Activation activity Adults Amino acid amino acids CD4 CD8 Cell cell fate complex Control cytosolic deficiency Degradation effector T cell ENhance expression favor follicular Genes Immunity impair in vitro inactivation increased expression independent individual individuals Infection inhibiting late endosome leucine lysosomal lysosome Lysosomes mammalian memory T memory T cells mTORC1 negative feedback loop Older plasma membrane platform prevented proliferative Rapamycin recall reduced response responses resulting SARS-CoV-2 peptide SLC7A5 sustained T cell T cell activation T cell response T helper cell terminally differentiated TFEB transcription factor transfer VPS39 [DOI] 10.1126/sciimmunol.abg0791 PMC 바로가기 [Article Type] Article