LZTFL1 – Communicable Diseases Research

Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19

Research article

Published on 2022-09-012022-10-05
Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘,

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

게놈 전체 분석은 ACE2가 COVID-19 위험에 영향을 미치고 심각한 질병과 관련된 위험 점수를 산출한다는 유전적 증거를 제공합니다

Article

Published on 2022-04-012022-09-11
Journal: Nature Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료법,

[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus allele frequency Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association cause clinical factor common variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease severity downregulate DPP9 enzyme Evidence Genetic Genome-wide association study human host cell human host cells identify IFNAR2 IMPROVE individual influence LZTFL1 MHC minor allele frequency Odds ratio outcome provide reduce replicate reported risk risk score SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease variant variants virus
[DOI] 10.1038/s41588-021-01006-7 PMC 바로가기 [Article Type] Article

CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1

CRISPRi는 COVID-19 GWAS 유전자좌를 LZTFL1 및 RAVER1에 연결합니다.

Article

Published on 2022-01-062022-09-11
Journal: EBioMedicine [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제,

[키워드] activated Affect affected airway Analysis antiviral immune response antiviral response cell lines chromosome coactivator coding regions conducted COVID-19 COVID-19 disease COVID-19 disease severity CRISPRi Critical Critical illness dataset datasets disease severity epithelial cell epithelial cells exonic region expression finding funding Gene expression analysis Genes Genetic variant Genome-wide association studies Genome-wide association study GWAS highest Host humans ICAM1 identified variant identify IFIH1 indicated induce intron investigated loci locus lung lung epithelial lung epithelial cell Lung epithelial cells LZTFL1 MDA5 neighbouring genes NIH non-coding regions pathway RAVER1 Region regulated risk allele RNA-Seq significantly sn/scRNA-seq SNPs susceptible variant Viral viral clearance was performed weakened with COVID-19
[DOI] 10.1016/j.ebiom.2021.103806 PMC 바로가기 [Article Type] Article

Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression

선택된 유전 인자가 SARS-CoV-2 감염 및 COVID-19 진행에 대한 감수성에 미치는 영향

Review

Published on 2021-12-162022-09-11
Journal: Physiological research [Category] SARS, 변종,

[키워드] ACE2 affected allele angiotensin Angiotensin-converting enzyme ApoE4 allele Blood Group CCR5 CD14 cells contribute coronavirus COVID-19 COVID-19 progression COVID-19 severity COVID-19 susceptibility disease severity Effect effort example Factor functional host immune system Human genome identify IL-10 Impact implicated in silico increased risk Intensive knowledge Knowledge deficit LZTFL1 Mortality OAS1 patients polymorphism Polymorphisms populations predictor predisposition Prevalence protein-coding gene protein-coding genes reported Research SARS-COV-2 infection selected severity shown silico studies susceptibility TMPRSS2 transferred variants Variation virus with COVID-19
[DOI] 10.33549/physiolres.934730 PMC 바로가기 [Article Type] Review

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Article

Published on 2021-12-072022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

Severe COVID-19 in Alzheimer’s disease: APOE4’s fault again?

알츠하이머 병의 심한 Covid-19 : APOE4의 잘못?

Commentary

Published on 2021-06-122022-09-10
Journal: Alzheimer's Research & Therapy [Category] MERS, SARS, 유전자 메커니즘,

Genetic variability in COVID-19-related genes in the Brazilian population

Article

Published on 2021-04-022022-10-04
Journal: Human Genome Variation [Category] 유전자 메커니즘,

[키워드] 1000 Genomes Project 1KGP ABO ACE2 ACE2 gene Affect allele frequency Analysis analyzed angiotensin-converting enzyme 2 Brazil Brazilian Brazilians candidate gene CCR9 Clinical prognosis contribute country COVID-19 COVID-19 case COVID-19 infection COVID-19 patients COVID-19 severity CTSL CXCR6 database disease DQB1 DRB1 examined Exome exomes explain FYCO1 gene sequence genetic background genetic study genetic variability Genetic variation Genome gnomAD help highest HLA allele Host host cells human lung cells identify IL6 Immunity implicated individual individual level infect Infection infection with SARS-CoV-2 Influenza virus information International investigated life-threatening loci LZTFL1 nonsynonymous Other Patient Phase 3 Pneumonia Population predicted previous study Protein Rare variants rate of infection recent receptor recorded reported risk SARS-CoV-2 SARS-COV-2 infection Seven shown SLC6A20 suggested susceptibility therapeutic targets TMPRSS2 transmembrane serine protease type I interferon unique university Variability variant Variation viral infection XCR1
[DOI] 10.1038/s41439-021-00146-w PMC 바로가기 [Article Type] Article

Genetics Insight for COVID-19 Susceptibility and Severity: A Review

COVID-19 감수성 및 심각도에 대한 유전학적 통찰: 검토

Review

Published on 2021-04-012022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] ABO ACE2 affecting allele alleles association Asymptomatic broad spectrum CCR9 Clinical course clinical manifestation clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 complication COVID-19 complications COVID-19 severity COVID-19 susceptibility CXCR6 cytokine Cytokine storm disease disease susceptibility expression FCGR2A FYCO1 genetic background Genetic variant genetic variants genetics GWAS HLA HLA-A Host IL17A IL1B IL1R1 IL1RN IL6 Infectious disease Infectious diseases insight inter-individual loci LZTFL1 mechanism outcome pathway Population receptor receptors reported review Risk factors SARS-CoV-2 several variants severity SLC6A20 SNV susceptibility the disease thrombosis thrombosis) TMPRSS2 TNF Variability variant variants Venous thrombosis with COVID-19 XCR1
[DOI] 10.3389/fimmu.2021.622176 PMC 바로가기 [Article Type] Review

Strong Correlation between the Case Fatality Rate of COVID-19 and the rs6598045 Single Nucleotide Polymorphism (SNP) of the Interferon-Induced Transmembrane Protein 3 ( IFITM3 ) Gene at the Population-Level

인구 수준에서 코로나19의 치사율과 인터페론 유도 막관통 단백질 3(IFITM3) 유전자의 rs6598045 단일 뉴클레오티드 다형성(SNP) 사이의 강한 상관관계

Brief Report

Published on 2020-12-302022-09-10
Journal: Genes [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 1000 Genomes Project ABO ABO gene ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition allele allele frequency angiotensin angiotensin I best Biomarker calculated Case fatality rate case fatality rates caused coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 case COVID-19 cases death distribution enzyme ethnic group Ethnic groups evaluated Fatality rate Genes Genetic Genetic polymorphism genetic polymorphisms Health Organization identify IFITM3 IL6 Infection interferon Interferon-induced transmembrane protein 3 interleukin 6 knowledge leucine LZTFL1 mechanism nucleotide pandemic disease Pathogenesis pathogenesis of COVID-19 performed polymorphism Polymorphisms protease Protein protein 3 Rate regression analysis reported respiratory risk SARS-CoV-2 SAS version 9.4 Serine serine 2 severe acute respiratory syndrome Coronavirus single nucleotide Single nucleotide polymorphism SNP Strong TMPRSS2 Transcription transmembrane transmembrane protein WHO World Health Organization
[DOI] 10.3390/genes12010042 PMC 바로가기 [Article Type] Brief Report