Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protectionSARS-CoV-2 보호의 기계적 상관 관계를 정의하기 위해 인간이 아닌 영장류에서 백신에 대한 반응 모델링Article Published on 2022-07-082022-09-12 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 appear approach binding Cell clearance Correlate of protection Critical decrease identify immunological immunology increase in infected cells Infection Inflammation inhibition main mechanism Mathematical modelling mechanism mRNA neutralization non-human primate RBD binding reduction in required rhesus rhesus macaque robust SARS-CoV-2 SARS-CoV-2 vaccine to define Vaccine vaccine platform Vaccines viral dynamics viral replication viruses [DOI] 10.7554/eLife.75427 PMC 바로가기 [Article Type] Article
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications Reviews Published on 2022-06-132022-10-05 Journal: Nature reviews. Cardiology [Category] 유전자 메커니즘, [키워드] activated Activation addition adipose advance Arrhythmias Atherosclerosis biological processes canonical cardiovascular disease cardiovascular system Cell complex component Diseases Effect Endothelial dysfunction fibrosis gene silencing heart failure implication include involved Ligand macrophage activation main mechanism mechanism monoclonal antibodies Myocardial obesity oxidative stress pathway Pathways phenotype receptors Regulation review RNA substantial risk therapeutic therapeutic potential therapeutic targeting tissue Treatment tumorigenesis Vascular vascular smooth muscle β-catenin [DOI] 10.1038/s41569-022-00718-5 [Article Type] Reviews
Tackling the emerging threat of antifungal resistance to human health Reviews Published on 2022-03-292022-10-05 Journal: Nature reviews. Microbiology [Category] 진단, [키워드] Bacterial diagnostics drugs fungal Fungal infection fungi global effort Health highlight hotspot include main mechanism mitigate one health pathogenic populations public health required Research review risk reduction similarity Surveillance therapy Transmission [DOI] 10.1038/s41579-022-00720-1 [Article Type] Reviews
Modeling the impact of SARS-CoV-2 variants and vaccines on the spread of COVID-19Research article Published on 2021-11-012022-10-05 Journal: Communications in Nonlinear Science and Numerical Simulation [Category] 변종, [키워드] 501.V2 African Characteristics contagious coronavirus country COVID-19 vaccines develop disease Effect effective effective reproduction number evaluate Evolution example expected Follow-up Government greater Infection infections Italy knowledge Laboratory less main mechanism mathematical measure modeling mortality rates Mutation observé outcomes pandemic question reduce reported Reproduction number Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly South Spread spread of COVID-19 the disease the vaccine United Kingdom vaccination vaccination rate Vaccine Vaccines variant virus VOC 202012/01 would increase θθ-SIR Type model [DOI] 10.1016/j.cnsns.2021.105937 [Article Type] Research article
Pathogenesis and treatment of cytokine storm in COVID-19Article Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] acute respiratory distress syndrome acute respiratory syndrome Anakinra antiviral agent antiviral immunity blocker caused Clinical course Clinical findings Clinical symptoms Complication coronavirus Corticosteroids COVID-19 cytokine response Cytokine storm death Diagnosis diagnosis of COVID-19 distress hyperinflammatory state IL-1 IL-6 blockers immunomodulatory drug immunosuppressive inhibit SARS-CoV-2 Insufficient Laboratory tests main mechanism Measures mechanism organ damage Pathogenesis pathogenesis of COVID-19 Patient persistence reduce Replication resulting SARS-CoV-2 suggested syndrome systemic inflammation the cytokine storm Tocilizumab treated Treatment viral clearance viral infection [DOI] 10.3906/biy-2105-37 PMC 바로가기 [Article Type] Article
Sustained expression of inflammatory monocytes and activated T cells in COVID‐19 patients and recovered convalescent plasma donorsOriginal Article Published on 2021-08-062022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, MERS, SARS, [키워드] activated T cell activated T cells activating acute respiratory syndrome Analysis analyzed B cell B‐cell Biliary CCR2 CD8 cellular response chemotactic convalescent plasma coronavirus coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 CX3CR1 cytokine cytokine production Cytokines disease Donor endothelial expected expression flow cytometry group growth healthy individual healthy subjects IL‐6 Immune cell immune cells immune response Immunity Infection infiltration Inflammatory marker inflammatory monocyte inflammatory protein inhibitory Leptin Ligand Lung injury Macrophage main mechanism Migration Mild MIP moderate monocyte Monocyte activation Monocytes New Patient patients performed Plasma cytokine positive Protein Proteins proteomics receptor recovered patient recovered patients recruited reduction in Result Saa1 serum significant increase sustained T cells target tissue Vascular [DOI] 10.1002/iid3.476 PMC 바로가기 [Article Type] Original Article
Pathological Features in 100 Deceased Patients With COVID-19 in Correlation With Clinical and Laboratory Data임상 및 실험실 데이터와 관련하여 COVID-19로 사망한 100명의 환자의 병리학적 특징Pathology and Oncology Archive Published on 2021-08-062022-09-10 Journal: Pathology and Oncology Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] alveolar damage Autopsies Autopsy caused change clinical Clinical data COVID-19 COVID-19 mortality COVID-19 viral pneumonia death Deceased described diagnosed with COVID-19 diffuse Diffuse alveolar damage disease Epigenetic evaluated Extensive Extrapulmonary Factor Genetic Healthcare system Healthcare systems histological subtype in some Laboratory laboratory findings large cohort limitation liver macroscopic main mechanism main mechanisms manifestation material morphology Mortality outcome pandemic pathological pathological features pathology Patient patients performed Pneumonia Post-mortem preventative measures protocol SARS-CoV-2 Septic shock severity spleen thrombosis Viral Viral pneumonia widespread with COVID-19 younger patients [DOI] 10.3389/pore.2021.1609900 PMC 바로가기 [Article Type] Pathology and Oncology Archive
Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in LiquoricePharmacology Published on 2021-07-062022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity addition Antiviral antiviral activity Antiviral effect binding derivative derivatives DNA drug combination Glycyrrhetinic acid glycyrrhizin HMGB1 HMGB1/TLR4 inactivation include inhibition of inflammation inhibitory effect liquorice main mechanism mechanisms modifications Progress reactive oxygen specy reduction in Research SARS-CoV-2 these compound triterpenoid virus replication viruses [DOI] 10.3389/fphar.2021.680674 PMC 바로가기 [Article Type] Pharmacology
Recent Advances on Nanomaterials to COVID‐19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS‐CoV‐2 Inhibition/InactivationReview Published on 2021-02-222022-10-31 Journal: Global Challenges [Category] COVID-19, [키워드] advance agent Antiviral article assays bioactive compounds candidate Cell cell mechanisms coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 described detect Diagnosis Drug administration facial Future Health help human host inhibit main mechanism Masks measure mechanism media medication Nanocellulose Nanomaterial nanomedicine Novel coronavirus outbreak overcome pandemic Pathogenesis phytochemical Polymeric nanoparticles preventing infection public health emergency recent reduce Research retrieved review SARS‐CoV‐2 self‐cleaning surfaces Side effect silver nanoparticle Spread Surveillance systematic review therapy treat trend Vaccine Vaccines viral inactivation virucidal [DOI] 10.1002/gch2.202000115 PMC 바로가기 [Article Type] Review
Circulating Exosomes Are Strongly Involved in SARS-CoV-2 InfectionMolecular Biosciences Published on 2021-02-222022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Activation addition Analysis approach AUC Biomarker Biomarkers C1r circulating Coagulation complement complement pathways component Course COVID-19 pathogenesis diagnostic Disease progression disease severity Exosome extracellular vesicle fibrinogen Host host cell host response host-response immune response Infection Inflammation investigated involved main mechanism modulate novel coronavirus SARS-CoV-2 organ dysfunctions plasma plasma exosomes presenting proteomic proteomics SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum amyloid shown Spread Therapeutic strategies tissue damage viral infection virus [DOI] 10.3389/fmolb.2021.632290 PMC 바로가기 [Article Type] Molecular Biosciences